The effect of age on the level of human ABO blood group antibodies

Saphire, Diane Griffin; Rudolph, Natalie S.; Hackleman, S. M.; Stone, W. H.

doi:10.1007/bf03324152

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…Although episodes of haemolysis in the recipients were not determined in this study so as to justify the clinical significance of such antibodies, it will be an overstatement to state that the frequency of strongly lytic anti-A and anti-B is low in this study. Taking a visual titre of 8 and above as being able to cause significant in vivo haemolysis [13], only 0.4% of the sera positive for alphahaemolysin and 0.2% of those positive for beta-haemolysin had significant visual titre of 8. Similarly, a titre of 16 was seen in only 0.2% for haemolytic anti-A and 0.1% for haemolytic anti-B.…”

Section: Discussionmentioning

confidence: 98%

Anti-A and Anti-B Haemolysins amongst Group “O” Voluntary Blood Donors in Northeastern Nigeria

Kagu

Ahmed

Mohammed

et al. 2011

Journal of Transfusion

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. One thousand nine hundred and twenty nine voluntary group "O" blood donors (1609 males and 320 females, median age 26 years ± 7.6 SD) were screened for alpha-(anti-A) and beta-(anti-B) haemolysins using the standard tube technique at 37 degrees C for 1 hour. All samples showing haemolysis were titrated for anti-A and anti-B haemolysins. Results. The overall prevalence of haemolysins in group O donors was 55.4%. Prevalence of alpha-and beta-haemolysins only was 10.3% and 12.6%, respectively, while that of donors having both alpha-and beta-haemolysins in their sera was 32.5%. Visual titre of 8 was seen in 0.4% of lytic alpha-haemolysin and 0.2% of lytic beta-haemolysin whereas donors with both alpha-and beta-haemolysins had a titre of 1.8%. Lytic titre of 16 and 32 was very low in our donor population. Conclusion. This study has shown that although the prevalence of haemolysins is high in our voluntary group "O" donor population, the strength of the lytic antibodies is low. Therefore, despite the labour intensiveness of our haemolysis titration technique and the frequent transfusion of group O blood to certain recipients of blood group A, B, and AB in our environments, there is the need to routinely screen our donors for haemolysins in order to identify those posing the greatest risk to recipients. Further studies to determine episodes of clinically significant haemolysis in recipients of blood group O may be necessary.

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Section: Discussionmentioning

confidence: 98%

Anti-A and Anti-B Haemolysins amongst Group “O” Voluntary Blood Donors in Northeastern Nigeria

Kagu

Ahmed

Mohammed

et al. 2011

Journal of Transfusion

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“…18.6% of samples thus had visual titres of 8 and above which is able to cause significant in vivo hemolysis. [13,16] This finding is similar to that reported by Adewuyi et al among black Zimbabweans [6] but higher than that reported by Olawumi and Olatunji who found a significant prevalence titre of 2.0% for anti-A and 2.8% for anti-B [8] and Kagu et al that found prevalence of 0.4% for anti-A and 0.2% for anti-B. [17] Such difference may be explained by the large sample size used by Kagu et al compared with that used in this study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of anti-A and anti-B hemolysis among blood group O donors in Lagos

2015

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“…This higher finding can be explained by the higher prevalence of hemolysins in Black population. Visual titres of hemolysins of 8 and above have been associated with significant in vivo hemolysis [ 17 , 23 ]. Assuming those with significant visual titre as being capable of leading to severe ABO HDN, potentially 2.7% of deliveries (18.6% of 14.3% deliveries) will have moderately severe to severe ABO HDN.…”

Section: Discussionmentioning

confidence: 99%

Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

Akanmu

Oyedeji

Adeyemo

et al. 2015

Journal of Blood Transfusion

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Background. ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim. We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods. Prevalence of ABO blood group phenotypes in blood donors at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABO HDN. Results. Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood group O woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.

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The effect of age on the level of human ABO blood group antibodies

Cited by 11 publications

References 8 publications

Anti-A and Anti-B Haemolysins amongst Group “O” Voluntary Blood Donors in Northeastern Nigeria

Anti-A and Anti-B Haemolysins amongst Group “O” Voluntary Blood Donors in Northeastern Nigeria

Prevalence of anti-A and anti-B hemolysis among blood group O donors in Lagos

Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

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