The effect of age on the dynamics and the level of c-Fos activation in response to acute restraint in Lewis rats

Meyza, Ksenia Z.; Boguszewski, Paweł M.; Nikolaev, Evgeni; Zagrodzka, Jolanta

doi:10.1016/j.bbr.2007.03.007

Cited by 22 publications

(21 citation statements)

References 40 publications

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“…The expression of c-Fos is commonly used as a marker for neuronal activity following a stimulus 25 . We stained the hippocampus for c-Fos under basal conditions or 90 min after stress, at the time of peak expression after stimulation 26 . In accordance to our previous results, the numbers of c-Fos-positive cells in the DG and CA3 after stress stimulation were significantly increased in WT, while no significant difference in CA1 was observed ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle

Tsai

Arnold

et al. 2015

Nat Commun

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The functional role of adult neurogenesis in the hippocampus remains the subject of intense speculation. One recent hypothesis is that adult-born neurons contribute to the endocrine and behavioural outputs of the stress response. Here we show a genetic model system to ablate neurogenesis by inducibly deleting Tbr2 gene function specifically in the hippocampus and corroborate our findings in a radiation-based model of neurogenesis deprivation. We found that mice with ablation of new neurons in the dentate gyrus exhibit reduced anxiety during the dark cycle. After restraint stress, corticosterone levels in neurogenesis-deficient mice decreased more quickly than controls and were more sensitive to suppression by dexamethasone. Furthermore, glucocorticoid receptor target genes and neuronal activity markers showed reduced expression after stress in neurogenesis-deficient mice. These findings suggest that newborn neurons in the hippocampus are involved in sensing and eliciting an appropriate response to stress.

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Section: Resultsmentioning

confidence: 99%

Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle

Tsai

Arnold

et al. 2015

Nat Commun

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“…While the aging HPA axis is considered hyper-active (Meaney et al, 1992; Bizon et al, 2001; Herman et al, 2001; McEwen, 2008; Lupien et al, 2009), central components like excitatory amino acid level, corticotropin-releasing hormone, glucocorticoid receptor level, and CNS localized amplification of glucocorticoid action likely play a role (Lowy et al, 1995; Mabry et al, 1995; Herman et al, 2001; McEwen, 2001; Meyza et al, 2007; Yau and Seckl, 2012). As opposed to exaggerated glucocorticoid responses to non-psychosocial stressors (Sapolsky et al, 1986a) aged animals appear to have either the same or a blunted corticosterone or nerve growth factor response to psychosocial stressors like restraint (Stewart et al, 1988; Scaccianoce et al, 2000; Herman et al, 2001; Shoji and Mizoguchi, 2010; Garrido et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging

Buechel

Popović

Staggs

et al. 2014

Front. Aging Neurosci.

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Cognitive processes associated with prefrontal cortex and hippocampus decline with age and are vulnerable to disruption by stress. The stress/stress hormone/allostatic load hypotheses of brain aging posit that brain aging, at least in part, is the manifestation of life-long stress exposure. In addition, as humans age, there is a profound increase in the incidence of new onset stressors, many of which are psychosocial (e.g., loss of job, death of spouse, social isolation), and aged humans are well-understood to be more vulnerable to the negative consequences of such new-onset chronic psychosocial stress events. However, the mechanistic underpinnings of this age-related shift in chronic psychosocial stress response, or the initial acute phase of that chronic response, have been less well-studied. Here, we separated young (3 month) and aged (21 month) male F344 rats into control and acute restraint (an animal model of psychosocial stress) groups (n = 9–12/group). We then assessed hippocampus-associated behavioral, electrophysiological, and transcriptional outcomes, as well as blood glucocorticoid and sleep architecture changes. Aged rats showed characteristic water maze, deep sleep, transcriptome, and synaptic sensitivity changes compared to young. Young and aged rats showed similar levels of distress during the 3 h restraint, as well as highly significant increases in blood glucocorticoid levels 21 h after restraint. However, young, but not aged, animals responded to stress exposure with water maze deficits, loss of deep sleep and hyperthermia. These results demonstrate that aged subjects are hypo-responsive to new-onset acute psychosocial stress, which may have negative consequences for long-term stress adaptation and suggest that age itself may act as a stressor occluding the influence of new onset stressors.

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“…Including more time points after stress also may have been informative. For example, other studies have reported a secondary wave of Fos (Meyza et al, 2007) and of Zif268 (Day et al, 2001) expression in the amygdala 4 h after a stress exposure. Further, glucocorticoid receptor‐induced hippocampal zif268 expression has been shown to occur through the activation of both rapid‐onset and slow‐onset pathways (Revest et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of social context on endocrine function and Zif268 expression in response to an acute stressor in adolescent and adult rats

Hodges

Green

Simone

et al. 2014

Intl J of Devlp Neuroscience

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There is a paucity of studies comparing social buffering in adolescents and adults, despite their marked differences in social behavior. We investigated whether greater effects of social buffering on plasma corticosterone concentrations and expression of Zif268 in neural regions after an acute stressor would be found in adolescent than adult rats. Samples were obtained before and after 1h of isolation stress and after either 1 or 3h of recovery back in the colony with either a familiar or unfamiliar cage partner. Adolescent and adult rats did not differ in plasma concentrations of corticosterone at any time point. Corticosterone concentrations were higher after 1h isolation than at baseline (p<0.001), and rats with a familiar partner during the recovery phase had lower corticosterone concentrations than did rats with an unfamiliar partner (p=0.02). Zif268 immunoreactive cell counts were higher in the arcuate nucleus in both age groups after isolation (p=0.007) and in the paraventricular nucleus of adolescents than adults during the recovery phase irrespective of partner familiarity. There was a significant decrease in immunoreactive cell counts after 1h isolation compared to baseline in the basolateral amygdala, central nucleus of the amygdala, and in the pyramidal layer of the hippocampus (all p<0.05). An effect of partner familiarity on Zif268 immunoreactive cell counts was found in the granule layer of the dentate gyrus irrespective of age (higher in those with a familiar partner, p=0.03) and in the medial prefrontal cortex in adolescents (higher with an unfamiliar partner, p=0.02). Overall, the acute stress and partner familiarity produced a similar pattern of results in adolescents and adults, with both age groups sensitive to the social context.

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The effect of age on the dynamics and the level of c-Fos activation in response to acute restraint in Lewis rats

Cited by 22 publications

References 40 publications

Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle

Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle

Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging

Effects of social context on endocrine function and Zif268 expression in response to an acute stressor in adolescent and adult rats

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