1979
DOI: 10.2337/diab.28.4.324
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The Effect of Age on Insulin-degrading Activity in Rat Tissue

Abstract: Insulin-degrading activity was measured in the 100,000g supernatant fraction of muscle, liver, and kidney from rats of varying ages. Young animals (four weeks old) had the highest activity in all three tissues. By seven weeks of age the activity in both muscle and liver had decreased significantly as compared with four-week-old animals. A slight but nonsignificant decrease occurred in kidney. In animals over one year of age the insulin-degrading activity in all three tissues was significantly less than the act… Show more

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Cited by 27 publications
(12 citation statements)
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“…Reduced hepatic insulin extraction has been reported in other insulin-resistant states, such as obesity 24 and non-insulin-dependent diabetes, 25 and decreased insulin-degrading activity has been noted in hepatic tissue from elderly rats. 26 We recognize, however, that this hypothesis is speculative, since our studies were not designed to assess hepatic insulin extraction.…”
Section: Discussionmentioning
confidence: 96%
“…Reduced hepatic insulin extraction has been reported in other insulin-resistant states, such as obesity 24 and non-insulin-dependent diabetes, 25 and decreased insulin-degrading activity has been noted in hepatic tissue from elderly rats. 26 We recognize, however, that this hypothesis is speculative, since our studies were not designed to assess hepatic insulin extraction.…”
Section: Discussionmentioning
confidence: 96%
“…11 This larger proinsulin component may have to do with altered metabolism of the peptide in plasma, 22 and the recent observation that age leads to a reduction in liver and muscle degradation of insulin provides a precedent for this possibility. 23 Obviously, additional experiments will have to be performed to reconcile the apparent discrepancies between the in vitro and in vivo results.…”
Section: Discussionmentioning
confidence: 97%
“…As with GIT, the levels of circulating insulin appear to affect activity with insulin deficiency due to either fasting or diabetes decreasing the activity levels and excess insulin increasing the activity (111). Age also has been shown to be important, with a fall in insulin-degrading activity with increasing age (115).…”
Section: Spring 1981mentioning
confidence: 98%