The Effect of Age on Huggins' Pitch Processing and its Location in Auditory Cortex

Rupp, André; Hauck, Matthias; Dosch, H. G.; Patterson, Roy D.

doi:10.3813/aaa.919223

Cited by 2 publications

(4 citation statements)

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“…The SCA3 mutation carriers in the present study were carefully age-matched with a control group of healthy adults. It is therefore unlikely that the perceptual and neuromagnetic decrements of this group regarding Huggins pitch simply occurred due to age-related changes in binaural processing [ 14 ]. Interestingly, the SCA3-related MEG decrement arose solely in the Huggins pitch condition but not in the condition that included an IRN pitch without binaural synchronization, and also not in the condition that included interaural broadband correlation changes without pitch .…”

Section: Discussionmentioning

confidence: 99%

“…Together, temporal precision renders binaural hearing a valid model to study the integrity of central neural processing, and even subtle jitter in binaural input synchronization can induce psychoacoustic and neurophysiological performance decrements. [12][13][14] A simple and intriguing tool to study binaural processing is the so-called Huggins pitch phenomenon [15]. When a white noise is presented diotically, listeners hear it as a simple noise without any pitch; however, if a continuous phase shift (2π) is imposed across a narrow frequency band at one of the two ears, a faint pitch-the Huggins pitchcan be perceived within the noise.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered binaural hearing in pre-ataxic and ataxic mutation carriers of spinocerebellar ataxia type 3

et al. 2023

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Brainstem degeneration is a prominent feature of spinocerebellar ataxia type 3 (SCA3), involving structures that execute binaural synchronization with microsecond precision. As a consequence, auditory processing may deteriorate during the course of disease. We tested whether the binaural “Huggins pitch” effect is suitable to study the temporal precision of brainstem functioning in SCA3 mutation carriers. We expected that they would have difficulties perceiving Huggins pitch at high frequencies, and that they would show attenuated neuromagnetic responses to Huggins pitch. The upper limit of Huggins pitch perception was psychoacoustically determined in 18 pre-ataxic and ataxic SCA3 mutation carriers and in 18 age-matched healthy controls. Moreover, the cortical N100 response following Huggins pitch onset was acquired by means of magnetoencephalography (MEG). MEG recordings were analyzed using dipole source modeling and comprised a monaural pitch condition and a no-pitch condition with simple binaural correlation changes. Compared with age-matched controls, ataxic but not pre-ataxic SCA3 mutation carriers had significantly lower frequency limits up to which Huggins pitch could be heard. Listeners with lower frequency limits also showed diminished MEG responses to Huggins pitch, but not in the two control conditions. Huggins pitch is a promising tool to assess brainstem functioning in ataxic SCA3 patients. Future studies should refine the psychophysiological setup to capture possible performance decrements also in pre-ataxic mutation carriers. Longitudinal observations will be needed to prove the potential of the assessment of Huggins pitch as a biomarker to track brainstem functioning during the disease course in SCA3.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered binaural hearing in pre-ataxic and ataxic mutation carriers of spinocerebellar ataxia type 3

et al. 2023

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“…Other researchers have used EEG and reported ACCs to the onset of AM imposed on a stimulus, although this inevitably introduces a momentary increase or decrease in level it has been argued that the ACC reflects the response to the AM per se rather than to this transient change [21,56]. The second strand comes from MEG studies showing a cortical response to the transition between a white noise and an iteratively rippled noise (IRN) or between two IRNs that elicit different pitches [57][58][59]. IRNs can be produced by delaying and adding a white noise to itself and repeating this process multiple times (iterations); this leads to a sound with a pitch roughly equal to the reciprocal of the delay, and a pitch strength that increases as more iterations are added [60].…”

Section: Accmentioning

confidence: 99%

Electrophysiological and Psychophysical Measures of Temporal Pitch Sensitivity in Normal-hearing Listeners

Guérit

Harland

Richardson

et al. 2022

JARO

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To obtain combined behavioural and electrophysiological measures of pitch perception, we presented harmonic complexes, bandpass filtered to contain only high-numbered harmonics, to normal-hearing listeners. These stimuli resemble bandlimited pulse trains and convey pitch using a purely temporal code. A core set of conditions consisted of six stimuli with baseline pulse rates of 94, 188 and 280 pps, filtered into a HIGH (3365–4755 Hz) or VHIGH (7800–10,800 Hz) region, alternating with a 36% higher pulse rate. Brainstem and cortical processing were measured using the frequency following response (FFR) and auditory change complex (ACC), respectively. Behavioural rate change difference limens (DLs) were measured by requiring participants to discriminate between a stimulus that changed rate twice (up-down or down-up) during its 750-ms presentation from a constant-rate pulse train. FFRs revealed robust brainstem phase locking whose amplitude decreased with increasing rate. Moderate-sized but reliable ACCs were obtained in response to changes in purely temporal pitch and, like the psychophysical DLs, did not depend consistently on the direction of rate change or on the pulse rate for baseline rates between 94 and 280 pps. ACCs were larger and DLs lower for stimuli in the HIGH than in the VHGH region. We argue that the ACC may be a useful surrogate for behavioural measures of rate discrimination, both for normal-hearing listeners and for cochlear-implant users. We also showed that rate DLs increased markedly when the baseline rate was reduced to 48 pps, and compared the behavioural and electrophysiological findings to recent cat data obtained with similar stimuli and methods.

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The Effect of Age on Huggins' Pitch Processing and its Location in Auditory Cortex

Cited by 2 publications

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Altered binaural hearing in pre-ataxic and ataxic mutation carriers of spinocerebellar ataxia type 3

Altered binaural hearing in pre-ataxic and ataxic mutation carriers of spinocerebellar ataxia type 3

Electrophysiological and Psychophysical Measures of Temporal Pitch Sensitivity in Normal-hearing Listeners

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