The Effect of Age on the Nerve Fiber Population of the Human Optic Nerve

Balazsi, A. Gordon; Rootman, Jack; Drance, Stephen M.; Schulzer, Michael; Douglas, Gordon R.

doi:10.1016/0002-9394(84)90509-9

Cited by 452 publications

(256 citation statements)

References 13 publications

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“…In the current study, one author drew the contour of the optic disc without any patient information, which eliminated intra-observer variation affecting the results. Some histological studies have shown an annual loss of nerve fibers (Balazsi et al 1984;Mikelberg et al 1991;Repka & Quigley 1989), and the number of nerve fibers is strongly correlated with the C/ D ratio and the neuroretinal rim volume (Quigley et al 1981). Therefore, it is possible that the optic disc configuration could be changed with age.…”

Section: Discussionmentioning

confidence: 99%

“…Loss of ganglion cell nerve fibers with age has been reported, indicating that the optic disc may change with age. (Balazsi et al 1984;Mikelberg et al 1991;Repka & Quigley 1989). Indeed, several reports have revealed age-related changes in the optic disc configuration (Carpel & Engstrom 1981;Garway-Heath et al 1997;Healey et al 1997;Tsai et al 1992), while other reports have demonstrated no age-related changes (Britton et al 1987;Funk et al 1989;Gundersen et al 1998;Jonas et al 1988;Varma et al 1994).…”

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confidence: 98%

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The influence of age, gender, refractive error, and optic disc size on the optic disc configuration in Japanese normal eyes

Kashiwagi

Tamura

Abe

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To investigate the influence of age, gender, refractive error, and optic disc size on optic disc configuration in Japanese normal eyes. Methods: Ninety-two eyes from 92 visually normal Japanese subjects (mean refractive error∫SD: ª1.26∫2.25 D, range ª8 D to π3 D) were examined using a confocal scanning laser tomograph, TopSS A . The following disc parameters were investigated: disc size, total or quadrant C/D area ratio and neuroretinal rim area, half-depth area, volume below, and average cup depth. Results: The disc diameter ( mean∫SD: 1.84∫0.16 mm) and disc size showed highly significant correlations with the C/D ratio (p∞0.001) and the neuroretinal rim area (p∞0.001). No other correlation was observed. Conclusion: These results indicate that the optic disc diameter and disc size have higher correlations with the optic disc configuration than age, gender, and refractive error in Japanese. These results are similar to those data reported for eyes of Caucasians or Afro Americans, and should be considered when optic discs are evaluated.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

The influence of age, gender, refractive error, and optic disc size on the optic disc configuration in Japanese normal eyes

Kashiwagi

Tamura

Abe

et al. 2000

Acta Ophthalmologica Scandinavica

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“…In some studies of human, axon numbers have been seen to decrease (Balaszi et al, 1984;Dolman et al, 1980;Johnson et al, 1987;Jonas et al, 1990;Mickelberg et al, 1989) and in others to remain unchanged (Repka and Quigley, 1989). Poor fixation of unperfused human nerves may well compromise an accurate count.…”

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confidence: 99%

Neuronal density in the human retinal ganglion cell layer from 16-77 years

et al. 2000

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“…Several earlier studies have shown a decrease in RNFL thickness with age by OCT or in RNFL axons by histological analysis. 11,12 A third histological study failed to find any difference in the number of axons between older and younger individuals. 13 Conflicting results in histological studies may be because these studies look at relatively few subjects and there is a large variation in the number of RNFL axons in normal individuals, between 7,00,000 and 1.4 million.…”

Section: Discussionmentioning

confidence: 97%

OCT based Comparison of RNFL Thickness in Low to Moderate Myopic Eyes with NORMAL and Raised IOP

2016

IJSR

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with raised corrected IOP (≥22mmHg) were included in this cross-sectional study. Three circular scans were obtained for each eye at diameter of 3.4mm around the optic disc using RTVue OCT. A single index of average RNFL thickness throughout 360 degree was obtained. The mean RNFL of (n=60) eyes with raised IOP was compared with age matched randomly selected (n=60) eyes with normal IOP. Results: Mean RNFL was significantly thinner in eyes with raised IOP than in eyes with normal IOP, 91.01 ± 11.95 and 101.52 ± 10.13 respectively. Conclusion: These findings suggest that quantitative differences in RNFL thickness exist between age-matched low to moderate myopic eyes with normal and raised IOP. Thus, all myopic individuals with raised IOP should be considered for OCT to assess for damage of RNFL, as they are at risk of developing glaucoma in future.

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The Effect of Age on the Nerve Fiber Population of the Human Optic Nerve

Cited by 452 publications

References 13 publications

The influence of age, gender, refractive error, and optic disc size on the optic disc configuration in Japanese normal eyes

The influence of age, gender, refractive error, and optic disc size on the optic disc configuration in Japanese normal eyes

Neuronal density in the human retinal ganglion cell layer from 16-77 years

OCT based Comparison of RNFL Thickness in Low to Moderate Myopic Eyes with NORMAL and Raised IOP

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