The effect of age, ethnicity and geographical location on impotence and quality of life

Jønler, Morten; Moon, Timothy D.; Brannan, William; Stone, Nelson N.; Heisey, Dennis M.; Bruskewitz, Reginald C.

doi:10.1111/j.1464-410x.1995.tb07426.x

Cited by 177 publications

(115 citation statements)

References 8 publications

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“…While some researchers have examined the relationship of marital status and mortality in prostate cancer, 17±18 none has addressed the effect of marital status on HRQOL outcomes. Furthermore, few studies have speci®cally addressed the effect of age 19 or insurance status on quality of life outcomes in prostate cancer. This study was designed to examine whether these and other sociodemographic and clinical variables are predictive of HRQOL outcomes in prostate cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Penson

Litwin

Lubeck

et al. 1998

Prostate Cancer Prostatic Dis

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Health-Related Quality of Life (HRQOL) is an important outcome measure in the study of prostate cancer. There are few data regarding the effect of sociodemographic variables, such as insurance status, educational level, marital status or income, on HRQOL. We examined whether these or other sociodemographic and clinical variables are predictive of HRQOL outcomes using an observational database of prostate cancer patients accrued from a wide array of clinical practice settings.We studied 131 patients with newly-diagnosed prostate cancer who had been followed for at least nine months. Patients were enrolled in CaPSURE TM , a large, observational database of patients with prostate cancer. General and diseasespeci®c HRQOL were measured with established, validated instruments at diagnosis and nine months later. Sociodemographic data and co-morbidity counts were recorded at baseline. Multivariate regression analysis was used to determine whether sociodemographic or clinical variables were predictive of baseline HRQOL or HRQOL changes during the study period.Several sociodemographic and clinical variables demonstrated signi®cant associations with HRQOL. We found improvements in general and diseasespeci®c domains of HRQOL during the nine months after diagnosis. For married patients, Emotional Well-Being and Family Functioning scores were better at baseline ( 11.8, P`0.02), but Family Functioning declined over the nine month study period (À18.5, P 0.0006). Older patients had slightly better baseline performance in several domains of HRQOL, but experienced greater HRQOL decrements over time than did younger patients. Increasing comorbidity was associated with worse baseline general HRQOL. Early tumor stage was predictive of better scores in general HRQOL domains at baseline. Limited palpable disease stage (T2A/T2B) was predictive of worse Sexual Function and Sexual Bother at nine months (À8.6, P 0.04; À24, P 0.008).After initial decreases, patients appear to experience an improvement in general and disease-speci®c HRQOL within nine months of initial diagnosis with prostate cancer. Marital status is associated with better HRQOL, while advancing age is associated with more signi®cant HRQOL declines over time. Patients with lower stage disease were noted to have better general HRQOL at baseline, although decreases in the physical domains were noted at nine months. These data shed new light on patients' experience with prostate cancer and suggest that HRQOL outcomes over time may occur in a predictable manner.

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Section: Introductionmentioning

confidence: 99%

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Penson

Litwin

Lubeck

et al. 1998

Prostate Cancer Prostatic Dis

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“…Age is an important factor to examine as it has a strong correlation with ED and can affect the rate of ED in a survey [2,4]. The strati®ed prevalence of ED by age is often omitted in studies or made unreliable because there are too few subjects in each of the age ranges [1,2].…”

Section: Discussionmentioning

confidence: 99%

An investigation of erectile dysfunction in Gwent, Wales

Green

Holden²,

Ingram

et al. 2001

BJU International

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Objective To quantify incidence of erectile dysfunction (ED) and the associated risk factors in men attending community clinics in a large population in Wales, UK. Subjects and methods Of 4060 men who were invited to attend 11 community clinics, primarily to check for prostate disease, 2025 (aged 55±70 years) attended. Of these, 2002 men answered a questionnaire about personal details, medical, family and sexual history, and detailed alcohol and smoking habits. All had their serum prostate-speci®c antigen (PSA) analysed and those referred for investigation of prostatic disease underwent serum testosterone analysis. Results Complete ED was reported by 265 men (13.2%), and was closely related to age (r=0.19, P<0.001) and medication (r=0.2, P<0.001). ED occurred in 6.9% of men aged 55±60 years, 12.5% aged 61±65and 22.2% of those aged 66±70. Patients taking diabetic medication had the highest relative risk for ED and 11.3% of men with ED were taking nitrates. The numbers of years of smoking had the third closest correlation with impotence (r=0.16, P<0.001). A low serum testosterone level was a poor predictor of ED and increasing serum PSA levels did not in¯uence the distribution of ED. Conclusion About 13% of these men aged 55±70 years had complete ED; if this value is extrapolated to the whole of the UK, this equates to almost half a million men being unable to achieve any erections. The estimate would be much greater if those with milder forms of ED are included.

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“…Our estimated response rate of 64.8% and participation rate of 88% are comparable to other studies. 2,3,11,15,16 Diokno et al 9 found that 73.8% married men above the age of 60 y were still sexually active. In the age group 60±69 y, Keil et al 17 reported that 70% were sexually active.…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction in general medicine practice: prevalence and clinical correlates

et al. 2000

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Erectile dysfunction (ED) is a common problem in general medical practice affecting especially the elderly and those with cardiovascular disease and diabetes mellitus. A study was undertaken by questionnaire distributed to consecutive adult male attendees at 62 general medical practices. 1240 completed questionnaires were available for analysis. The mean age of participants was 56.4 y (range 18 ± 91 y). 488 men (39.4%) reported ED: 119 (9.6%)`occasionally', 110 (8.9%)`often', and 231 (18.6%)`all the time' (complete ED). Among 707 men aged 40±69 y 240 (33.9%) reported ED and 84 (11.9%) had complete ED. The prevalence of complete ED increased with age, rising from 2.0% in the 40 ± 49 y age group to 44.9% in the 70±79 y age group. Only 11.6% of men with ED had received treatment. Hypertension, ischaemic heart disease, peripheral vascular disease and diabetes mellitus were frequently associated with ED. 40% of diabetic men aged 60 y or older had ED all the time.

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The effect of age, ethnicity and geographical location on impotence and quality of life

Abstract: This study indicates that impotent men have a lower quality of life than potent men and has confirmed previous findings that age is associated with impotence. Surprisingly, answers to impotence questions were also associated with geographical location.

Cited by 177 publications

References 8 publications

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

Transitions in health-related quality of life during the first nine months after diagnosis with prostate cancer

An investigation of erectile dysfunction in Gwent, Wales

Erectile dysfunction in general medicine practice: prevalence and clinical correlates

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