The effect of age and compression strength on venous leg ulcer healing

Karanikolić, Vesna; Binić, Ivana; Jovanović, Dragan; Golubović, Maša; Golubović, Ilija; Djindjic, Natasa; Petrović, Dejan

doi:10.1177/0268355517749112

Cited by 14 publications

(12 citation statements)

References 19 publications

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“…The average number of kits used per patient was 17.6 for BIFLEX V R versus 33.2 for PROFORE V R (corresponding to a reduction of 47%, p < 0.001) over a similar average follow-up period (12.7 weeks) and nurse-visits (39.8 in BIFLEX V R vs. 39.4 in PROFORE V R group) ( Several factors such as age, obesity, size of the ulcer, wound duration or existence of deep venous aetiology can influence VLU healing. [21][22][23] Logistic regression analysis confirmed the superiority of BIFLEX V R Kit, regardless of any associated factors. An OR of $3 for BIFLEX V R Kit over PROFORE V R emphasized its benefit.…”

Section: Profore V R ) With No Statistical Difference In Between Groupsmentioning

confidence: 74%

“…These findings underline the need for a simple bandage system or any specific indication on the provided level of pressure. Although numerous studies have evaluated the impact of compression therapy on complete healing, 15,19,26–28,31 few data focused on the acceptability. Compliance in compression therapy is often reported as poor, ranging from just 15 to 30% in France and other European countries.…”

Section: Discussionmentioning

confidence: 99%

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Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial

Gillet¹,

Jj²,

Allaert

et al. 2019

Phlebology

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Objective To evaluate the efficacy, safety and acceptability of an innovative two-component versus a well-established four-component compression systems in the management of venous leg ulcer. Method Multicentre randomized controlled trial in patients with active venous leg ulcer. Patients were followed-up monthly for a maximum of 16 weeks. The primary endpoint was the complete healing rate at 16 weeks. Results Ninety-two patients were randomized to either the two-component BIFLEX® Kit group ( n = 49) or the four-component PROFORE® group ( n = 43). In the full analysis set ( n = 88), a complete healing rate of 48.9% and 24.4% was reported in BIFLEX® Kit versus PROFORE® groups, respectively (i.e. a superiority of 24.5%, p = 0.02). Acceptability of BIFLEX® Kit was higher from both the patients’ and physicians’ perspectives. Conclusion The BIFLEX® Kit represents a valid alternative therapy in the management of venous leg ulcer according to its clinical efficacy, safety and acceptability with potential positive impacts on healthcare costs.

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Section: Profore V R ) With No Statistical Difference In Between Groupsmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial

Gillet¹,

Jj²,

Allaert

et al. 2019

Phlebology

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“…2,4,6 Come è noto in circa il 30% dei casi queste lesioni non guariscono entro 6 mesi e l'identificazione dei fattori di rischio appare cruciale ai fini prognostici. 6 Nonostante i recenti progressi in tema di medicazioni avanzate e wound care, le recidive non sono infrequenti e rappresentano un problema per lo specialista ed il paziente; a tutt'oggi le evidenze della Letteratura indicano che il bendaggio elastocompressivo, in particolare ai livelli più alti di compressione, resta fondamentale per il successo del trattamento, 5,7,8 penalizzato spesso però dall'intolleranza del paziente. Alla luce di queste considerazioni crediamo sia importante poter disporre di profili di rischio utili ad indicare i soggetti che più facilmente possono andare incontro ad una recidiva; il nostro è uno studio che prende in considerazione la storia clinica del paziente in modo da poter già in prima battuta ed in sede di visita disporre di un indice prognostico.…”

Section: Discussioneunclassified

Le ulcere flebostatiche recidive degli arti inferiori: analisi di un’esperienza/Recurrent venous leg ulcers: clinical analysis of an experience

Ponte

Gilardi

et al. 2019

Ital J Wound Care

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Nonostante i recenti progressi in tema di wound care, le ulcere varicose degli arti inferiori restano un problema frequente, con un alto tasso di recidiva. In questo lavoro abbiamo esaminato la storia clinica, la storia chirurgica e le patologie associate di 133 pazienti affetti da ulcera varicosa degli arti inferiori, di cui 56 da ulcera recidiva o plurirecidiva. L’analisi dei fattori di rischio potenziale per recidiva ha evidenziato come la presenza di varici recidive, una pregressa trombosi venosa profonda, problemi ortopedici, interventi ortopedici, l’obesità e un’età inferiore a 60 anni siano fattori di rischio potenziale per una recidiva dell’ulcera. La combinazione di uno più fattori di rischio assume significatività per la possibilità di una recidiva; si passa dal 22,7% in assenza di fattori di rischio al 33% per i pazienti che ne presentano due, fino al 57,5% in presenza di tre fattori di rischio e all’81,3% per quattro o più. L’ulcera varicosa richiede un follow-up stretto del paziente e una terapia elastocompressiva continua, che deve vedere una stretta collaborazione del paziente e un’attenzione specifica ai fattori di rischio. Despite recent advances in wound care, varicose ulcers of lower limbs remain frequent and display a high rate of recurrence. In this paper, we examined the clinical, surgical histories and associated diseases of 133 patients with venous ulcers of the lower limbs, which were recurrent in 56 cases. The analysis of potential risk factors for recurrence showed that the presence of recurrent varicose veins, a previous deep venous thrombosis, orthopedic problems, previous orthopedic procedures, obesity and age lower than 60 are potential risk factors for ulcer recurrence. Furthermore, the association of one or more risk factors increased the likelihood of relapse, from 22.7% with no risk factors to 33% with 2 risk factors, up to 57.5% with 3 risk factors, and up to 81.3% with 4 risk factors or more. Venous ulcers require close follow-up and continuous elastic compression, close collaboration by the patient and specific focus on risk factors.

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“…If compression therapy is adequately applied, venous ulcers will heal in 40% to 95% of cases [19][20][21]. However, despite the application of adequate therapy, venous ulcers will not heal in a relatively large number of patients.…”

Section: Survival Functionsmentioning

confidence: 99%

The effectiveness of two different sub-bandage pressure values on healing and quality of life outcomes for patients with venous leg ulcers

Karanikolić¹,

Ignjatović²,

Marinkovic³

et al. 2023

pdia

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Introduction: Venous ulcers account for over 80% of chronic wounds in the lower extremities. Venous ulcers lead to a significant decrease in the patients' quality of life. Aim: To compare the effectiveness of two different sub-bandage pressure values on healing and quality of life outcomes. Material and methods:The study included 116 outpatients with venous leg ulcers (VLUs), one group with a moderate compression pressure of 35-40 mm Hg and the second with a high pressure > 45 mm Hg. The Kaplan-Meier curve and log rank test were used to estimate healing by type of compression. Quality of life measures included: Quality of Life Index (QL), Numeric Pain Rating Scale (NPRS) and Geriatric Depression Scale (GDS). Patients were followed for 24 weeks. Results: Kaplan-Maier analysis showed that a high pressure leads to a higher proportion of healed VLUs, compared to the moderate pressure (p = 0.011). QL, GDS and NPRS at the beginning were equalized between the groups. In patients with a high compression, there was a statistically significant increase in QL (p = 0.005), decrease in GDS (p = 0.040) and NPRS (p = 0.002) during 24 weeks. In patients with moderate compressions there was a statistically significant increase in QL (p = 0.013). Conclusions: Patients who received high pressure, healed faster. When a high pressure was applied, there was a statistically significant increase in QL, decrease in GDS and NPRS compared to the group of patients to whom the moderate pressure was applied.

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The effect of age and compression strength on venous leg ulcer healing

Cited by 14 publications

References 19 publications

Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial

Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial

Le ulcere flebostatiche recidive degli arti inferiori: analisi di un’esperienza/Recurrent venous leg ulcers: clinical analysis of an experience

The effectiveness of two different sub-bandage pressure values on healing and quality of life outcomes for patients with venous leg ulcers

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