The Effect of Age and Strain Differences on the Incidence of Restraint-Induced Oral and Gastric Ulcers in Three Strains of Rats

Abstract

Restraint of different strains of rat has been shown to be capable of inducing both oral and gastric ulcers. Hooded Wistar rats were most susceptible to gastric ulcers, whereas Sprague-Dawley rats had the highest incidence of oral ulcers. The causative mechanisms probably differ and are strain dependent.