The Effect of Age and Sex Upon Human Pancreatic Secretion of Fluid and Bicarbonate

Rosenberg, I. Richard; Friedland, Noel; Janowitz, Henry D.; Dreiling, David A.

doi:10.1016/s0016-5085(66)80052-5

Cited by 55 publications

(11 citation statements)

References 8 publications

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“…One explanation could be reduced levels of pancreatic enzyme secretion or more advanced atrophy of the pancreas in older patients. 7,[27][28][29] Pharmacologic intervention can help prevent post-ERCP pancreatitis, and routine rectal administration of diclofenac or indomethacin has been recommended for all patients without contraindication. 22 However, in a recent survey, only 34.6% of endoscopists used nonsteroidal antiinflammatory drugs for post-ERCP prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

ERCP in elderly patients: increased risk of sedation adverse events but low frequency of post-ERCP pancreatitis

Finkelmeier

Tal

Ajouaou

et al. 2015

Gastrointestinal Endoscopy

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Section: Discussionmentioning

confidence: 99%

ERCP in elderly patients: increased risk of sedation adverse events but low frequency of post-ERCP pancreatitis

Finkelmeier

Tal

Ajouaou

et al. 2015

Gastrointestinal Endoscopy

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“…These include proliferation of ductal epithelial cells with stratified squamous epithelium replacing normal ductal epithelium, fatty infiltration (up to 80%) and fibrosis (60%) [14,15]. Functionally, reduced levels of pancreatic enzymes have been noted in the duodenal aspirates of elderly patients [16].…”

Section: Discussionmentioning

confidence: 99%

ERCP in the Very Elderly: Outcomes Among Patients Older than Eighty

Lukens¹,

Howell

Upender

et al. 2009

Dig Dis Sci

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Life expectancy is rising, which is increasing the demand for endoscopic retrograde cholangiopancreatography (ERCP) in the elderly. Little data, particularly on complex procedures, has been reported. In this study, we compare the differences in the success and complications in ERCP between patients older and younger than 80 years old. We used a large endoscopic database reviewing the ERCPs performed and 30-day complications addressing age, degree of difficulty of procedures, and complications. A total of 2,606 patients underwent 3,924 ERCPs. Six hundred and twenty-eight were octogenarians undergoing 728 procedures. Mean age was 83.5 years in the octogenarian group and 59.0 years in the younger group. The endoscopic success rate was lower in octogenarians (96.9 vs. 98.3%, P = 0.004). Overall, complication rates between both groups was significantly less in older compared to younger patients (1.64 vs. 3.50%, P = 0.006). Complication and failure rates were higher as procedure complexity increased in all patients. ERCP in the elderly carries a high degree of success with low complication rates. Elderly patients carry similar risks of bleeding and perforation and a lower risk of pancreatitis.

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“…So far, very few studies have examined exocrine pancreatic function in the elderly and results have been conflicting. Rosenberg et al 12 evaluated the pancreatic secretion of bicarbonate in response to secretin stimulation in 44 individuals under the age of 50, and in 59 individuals over this age, and they did not observe significant differences between the two groups. Fikry, 4 by using the secretin test, found a decrease in the volume of duodenal aspirate and a selective reduction in enzyme activity (amylase and trypsin were low, whereas lipase was within normal limits) in 23 subjects aged 60 to 72 years.…”

Section: Discussionmentioning

confidence: 99%

Aging and Exocrine Pancreatic Function

Gullo

Ventrucci

Naldoni

et al. 1986

J American Geriatrics Society

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In view of the limited information concerning the influence of aging on exocrine pancreatic function, the authors undertook the present study. To examine a large number of elderly persons, including people of very advanced age (80 years and over), pancreatic function was studied by using the fluorescein dilaurate test (pancreolauryl test), one of the most recent tubeless, noninvasive pancreatic function tests. Sixty healthy noninstitutionalized elderly individuals (35 women and 25 men, aged 66 to 88 years, mean 78) participated in the study. Thirty-six healthy younger subjects (16 women and 20 men, aged 21 to 57 years, mean 36) were also studied as controls. All elderly subjects showed a strictly normal fluorescein dilaurate test. No significant differences in the pancreatic function test results were observed between the elderly under 80 years old and those over 80 years old. The authors conclude that the aging process per se does not significantly affect exocrine pancreatic function and, more particularly, does not impair the digestive capacity of the elderly person.

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The Effect of Age and Sex Upon Human Pancreatic Secretion of Fluid and Bicarbonate

Cited by 55 publications

References 8 publications

ERCP in elderly patients: increased risk of sedation adverse events but low frequency of post-ERCP pancreatitis

ERCP in elderly patients: increased risk of sedation adverse events but low frequency of post-ERCP pancreatitis

ERCP in the Very Elderly: Outcomes Among Patients Older than Eighty

Aging and Exocrine Pancreatic Function

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