The effect of age and density of the breast on the sensitivity of breast cancer diagnostic by mammography and ultasonography

Saarenmaa, Irma; Salminen, Tiina; Geiger, U; Heikkinen, Pirkko; Hyvärinen, S.; Isola, Jorma; Kataja, Vesa; Kokko, M L; Kokko, R.; Kumpulainen, E.; Kärkkäinen, A; Pakkanen, J; Peltonen, Pirkko; Piironen, Anneli; Salo, A; Talviala, Marja-Liisa; Hakama, Matti

doi:10.1023/a:1010627527026

Cited by 107 publications

(77 citation statements)

References 33 publications

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“…It would be tempting to interpret this as an indication of lowered screening sensitivity. Use of hormone replacement theraphy, an important determinant of interval cancer 7,27,29 due to increase in breast density, 30,31 almost doubled in the study period 32 and was on a higher level compared to that in the Netherlands 33 or Norway. [34][35][36] Another explanation is an increase in diagnostic activity other than screening due to improved access to diagnostic services.…”

Section: Discussionmentioning

confidence: 95%

Episode sensitivity in association with process indicators in the Finnish breast cancer screening program

Sarkeala

Hakama

Saarenmaa

et al. 2005

Intl Journal of Cancer

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We assessed the episode sensitivity of the Finnish mammography program for women aged 50-59 (partly 60-64) years and explored associations between the episode sensitivity and the screening process indicators from 1991 to 1999. For the study period, data were available from 10 screening centers. Records of 721,000 screening visits were linked to the files of the nationwide Finnish Cancer Registry from 1991 to 2001 at an individual level. The rates of screen-detected and interval breast cancers were calculated at the first and at the subsequent screens. The episode sensitivity was determined by contrasting the incidence of interval cancers with the expected population incidence rate without screening (incidence method) and as a proportion of interval cancers out of all cancers detected (detection method). At the subsequent screens, the episode sensitivity determined by the incidence method was 54% and by the detection method 65%. The sensitivity 0-11 and 12-23 months after the screening was 70% and 38%, respectively. The episode sensitivity decreased toward the end of the study period and increased with age. The center-specific sensitivity increased 13% per 1% absolute increase in the recall rate. In general, our study provides further information on the effectiveness of screening programs. The sensitivity estimates were comparable with those from other European service screening programs. The variability in the episode sensitivity suggests potential for variations in the future screening outcome. ' 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 95%

Episode sensitivity in association with process indicators in the Finnish breast cancer screening program

Sarkeala

Hakama

Saarenmaa

et al. 2005

Intl Journal of Cancer

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“…However, both methods present some limitations. Mammography performed in dense breasts may often yield false-negative results [1]. US is sensitive in the detection of lesions, but specificity is poor as most solid lesions are benign.…”

Section: Introductionmentioning

confidence: 99%

Breast elastography: A literature review

Goddi¹,

Bonardi

Alessi

2012

Journal of Ultrasound

138

129

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KEYWORDS Sonoelastography; Breast elastography; Breast lesions.Abstract Breast elastography is a new sonographic imaging technique which provides information on breast lesions in addition to conventional ultrasonography (US) and mammography. Elastography provides a noninvasive evaluation of the stiffness of a lesion. Today, two technical solutions are available for clinical use: strain elastography and shear wave elastography. Initial evaluations of these techniques in clinical trials suggest that they may substantially improve the possibility of differentiating benign from malignant breast lesions thereby limiting recourse to biopsy and considerably reducing the number of benign breast biopsy diagnoses. This article reviews the basics of this technique, how to perform the examination, image interpretation and the results of major clinical studies. Although elastography is easy to perform, training and technical knowledge are required in order to obtain images permitting a correct interpretation. This paper will highlight the technique and point out common pitfalls.Sommario L'elastosonografia mammaria è una nuova tecnica di imaging a ultrasuoni che fornisce informazioni aggiuntive sulle lesioni della mammella rispetto all'ecografia e alla mammografia. Consente una valutazione non invasiva della rigidità tessutale di una lesione. Sono attualmente disponibili due soluzioni tecniche per uso clinico: l'elastografia con strain e l'elastografia shear wave. I primi studi clinici di valutazione di queste tecniche suggeriscono che esse possano migliorare la caratterizzazione delle lesioni mammarie differenziando quelle benigne dalle maligne e riducendo in modo sostanziale il numero di biopsie per lesioni benigne. Questo articolo rivisita le basi tecniche, i criteri interpretativi delle immagini, i principali studi clinici e le possibili cause di errore. Per quanto l'elastosonografia sia di facile esecuzione, richiede tuttavia un training e delle conoscenze tecniche adeguate per ottenere immagini correttamente interpretabili. ª

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“…Many published studies have confirmed that the sensitivity of mammography increases with age. 9,10 The sensitivity of mammography may be decreased further in women who carry a deleterious mutation in BRCA1 or BRCA2; pilot studies evaluating mammography in BRCA1 and BRCA2 carriers have found a high rate of false-negative results. 6,11,12 This may be attributable both to increased breast density in young women and to tumor phenotype, including features such as pushing margins, which may contribute to a smooth appearance rather than a spiculated appearance of a mass on mammography.…”

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confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

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Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to investigate experimentally the impacts of the two properties with a conical high shear granulator. The results show significant effects of viscosity and surface tension on solids flow pattern and relative motion of particles. The relative importance of the two parameters, the surface tension and the viscosity, are found to vary with the axial and radial positions in the granulator. For example, the viscosity force decreases with an increase in the bed height in the axial direction (vertical plane). The viscosity force between particles coated with PEG4000 solution is in mN order, whereas that between particles coated with ethanol and water is in μN order. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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The effect of age and density of the breast on the sensitivity of breast cancer diagnostic by mammography and ultasonography

Cited by 107 publications

References 33 publications

Episode sensitivity in association with process indicators in the Finnish breast cancer screening program

Episode sensitivity in association with process indicators in the Finnish breast cancer screening program

Breast elastography: A literature review

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

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