The effect of aflatoxin B1 on the utilization of serum calcium

Abstract

The mathematical analysis for plasma disappearance curve of aflatoxicosed animals, subsequently injected with 45Ca was determined. The analysis showed that the three main compartments of the calcium pool (plasma, bone and the labile calcium pool on the surface of bone and soft tissues) had been affected. Specifically, the fractional rate constant for migration of 45Ca from plasma pool to the labile pool had been diminished to its third value. This led to a corresponding reduction in the calcium content of the bone ash. The probable mechanism by which aflatoxin B1 affects calcium dynamics may be interpreted by the inhibitory effect of aflatoxin in the hydroxylation mechanism of vitamin D3 into an active intermediate. During aflatoxicosis (induction of 15 days) the animals entered a state of calcium deficiency, secondary to intestinal absorption inhibition. This was followed by bone resorption and disturbance of the fractional removal rate constant among different calcium compartments.

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

“…Mycotoxins are secondary metabolites produced by Aspergillus, Penicillium and other genera which contaminate food and exhibit hazardous effects on humans and animals mainly malnutrition, immunosuppression, genotoxicity, carcinogenic and teratogenic effects due to inhibition of macromolecule synthesis and metabolism (Nassar et al 1985;Megalla et al 1990;Maresca and Fantini 2010;Adejumo and Adejoro 2014;Ashiq 2015;Tola and Kebede 2016). The AFs are referred to four different types and their metabolites contaminating the food of animals and humans (Nassar et al 1982;Hafez et al 1985;Rajendra et al 2014).…”