“…Some factors such as muscle weakness, inactivity, and overweight are factors which can be controlled during the life (5)(6)(7)(8). However, studies show that subjects who suffer from these conditions for any reason can recover with proper aerobic training and ozone therapy (5,(9)(10)(11). Due to the reports, aerobic training and ozone therapy positively affect genes related to cardiovascular health in the heart tissue of rats with osteoarthritis (9).…”