The effect of aerobic exercise on Neurofilament light chain and glial Fibrillary acidic protein level in patients with relapsing remitting type multiple sclerosis

Ercan, Zübeyde; Bilek, Furkan; Demir, Caner Feyzi

doi:10.1016/j.msard.2021.103219

Cited by 19 publications

(10 citation statements)

References 33 publications

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“…In relation to this, the so far promising use of the blood-based biomarkers neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) that are strongly associated with disease progression and specifically neurodegeneration [ 63 , 64 ] should be kept in mind. Some studies have reported that short-term (3–8 weeks) aerobic training can reduce serum/plasma levels of NfL and GFAP [ 65 , 66 ] in pwMS, whereas a long-term (24 weeks) aerobic training study failed to observe any changes in serum NfL [ 14 ]. However, none of these exercise studies carried out concomitant analyses of neurotrophic factors, which is an obvious knowledge gap that should be pursued in future.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis—A Systematic Review and Meta-Analysis

et al. 2021

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Background: Evidence indicates that exercise holds the potential to counteract neurodegeneration experienced by persons with multiple sclerosis (pwMS), which is in part believed to be mediated through increases in neurotrophic factors. There is a need to summarize the existing evidence on exercise-induced effects on neurotrophic factors alongside neuroprotection in pwMS. Aim: To (1) systematically review the evidence on acute (one session) and/or chronic (several sessions) exercise-induced changes in neurotrophic factors in pwMS and (2) investigate the potential translational link between exercise-induced changes in neurotrophic factors and neuroprotection. Methods: Five databases (Medline, Scopus, Web of Science, Embase, Sport Discus) were searched for randomized controlled trials (RCT) examining the effects of exercise (all modalities included) on neurotrophic factors as well as measures of neuroprotection if reported. The quality of the study designs and the exercise interventions were assessed by use of the validated tool TESTEX. Results: From N = 337 identified studies, N = 14 RCTs were included. While only N = 2 of the identified studies reported on the acute changes in neurotrophic factors, all N = 14 RCTs reported on the chronic effects, with N = 9 studies revealing between-group differences in favor of exercise. This was most prominent for brain-derived neurotrophic factor (BDNF), with between-group differences in favor of exercise being observed in N = 6 out of N = 12 studies. Meta-analyses were applicable for three out of 10 different identified neurotrophic factors and revealed that exercise can improve the chronic levels of BDNF (delta changes; N = 9, ES = 0.78 (0.27; 1.28), p = 0.003, heterogeneity between studies) and potentially also ciliary neurotrophic factor (CNTF) (N = 3, ES = 0.24 (−0.07; 0.54), p = 0.13, no heterogeneity between studies) but not nerve growth factor (NGF) (N = 4, ES = 0.28 (−0.55; 1.11), p = 0.51, heterogeneity between studies). Indicators of neuroprotection (e.g., with direct measures of brain structure assessed by MRI) were assessed in N = 3 of the identified studies only, with N = 2 partly supporting and thus indicating a potential translational link between increases in neurotrophic factors and neuroprotection. Conclusion: The present study reveals that exercise can elicit improvements in chronic levels of BDNF in pwMS, whereas the effects of exercise on chronic levels of other neurotrophic factors and on acute levels of neurotrophic factors in general, along with a potential translational link (i.e., with exercise-induced improvements in neurotropic factors being associated with or even mediating neuroprotection), are sparse and inconclusive. There is a need for more high-quality studies that assess neurotrophic factors (applying comparable methods of blood handling and analysis) concomitantly with neuroprotective outcome measures. Review Registration: PROSPERO (ID: CRD42020177353).

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Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis—A Systematic Review and Meta-Analysis

et al. 2021

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“…A number of observations do, however, counter these explanations. Firstly, and as already mentioned, shorter interventions have been shown to be able to affect serum NfL (Ercan et al, 2021;Joisten et al, 2021), although not in AD patients. Secondly, the intervention was able to improve symptoms of AD including cognitive function (Hoffmann et al, 2016).…”

Section: Discussionmentioning

confidence: 85%

“…Although this remains speculative, findings in multiple sclerosis demonstrate that exercise interventions of a short duration clearly attenuate measures related to neurodegeneration in a similar fashion as disease-modifying therapy. Specifically, in two studies in multiple sclerosis exercise interventions were able to modify serum concentrations of neurofilament light chain (NfL) ( Ercan et al, 2021 ; Joisten et al, 2021 ). Studies in AD on NfL (in serum or CSF) in blood and exercise are sparse.…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease

et al. 2023

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IntroductionAerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.ObjectiveTo investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer’s disease (AD).MethodsThis is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer’s disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.ResultsA total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOEε4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline −1.16, p = 0.09].ConclusionThe findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration.Clinical trial registrationclinicaltrials.gov, identifier NCT01681602.

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“…Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system that affects health-related quality of life with increasing disability (physical, cognitive, and mental) over time (Ercan et al, 2021;Reich et al, 2018). One of the most important causes of disability in persons with MS (PwMS) is gait disturbance (Coca-Tapia et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Validity and Reliability of the Turkish Version of the Self-Reported Disability Status Scale in Persons with Multiple Sclerosis

Bilek¹,

Demir²

2022

Balıkesır Health Sciences Journal

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Objective:The aim of this study was designed to investigate the validity, reliability, and cultural adaptation of the Turkish version of the self-reported disability status scale (SRDSS). Materials and Methods: This study was designed as prospective, methodological, and cross-sectional. Turkish translation and cross-cultural adaptation of SRDSS was conducted. SRDSS scores were compared with Expanded Disability Status Scale and Patient Determined Disease Steps to test the concurrent validity. The validity and test-retest reliability of the Turkish SRDSS were investigated in 128 persons with MS. Results: A very strong correlation was found between SRDSS and Expanded Disability Status Scale (r=-0.920, p=0.000) and Patient Determined Disease Steps (r=0.857, p=0.000). The mean of the first test of SRDSS was 1.29±0.59, and the mean of the retest test was 1.30±0.61. A very high correlation was found between test and retest (p<0.001, r=0.967). Bland-Altman analysis showed that SRDSS was reproducible with upper and lower limits of agreement of 0.2929 and -0.3089, respectively (bias=-0.008; p=0.566). Cronbach's alpha coefficient was found to be 0.983 (excellent reliability). For inter-rater agreement, the ICC values in the individual test were 0.967 (954 CI; 0.954-0.977). Conclusion: This study showed that the Turkish version of SDRSS is a valid and reliable measurement tool. In cases where Expanded Disability Status Scale cannot be applied, the Turkish version of SRDSS can be used as an alternative assessment method.

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The effect of aerobic exercise on Neurofilament light chain and glial Fibrillary acidic protein level in patients with relapsing remitting type multiple sclerosis

Cited by 19 publications

References 33 publications

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis—A Systematic Review and Meta-Analysis

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis—A Systematic Review and Meta-Analysis

Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease

Validity and Reliability of the Turkish Version of the Self-Reported Disability Status Scale in Persons with Multiple Sclerosis

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