The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation

Erdem, Kezban Tuna Ozkaloglu; Bedir, Zehra; Ateş, İrem; Kuyrukluyıldız, Ufuk; Çoban, Taha Abdulkadir; Yazıcı, Gülce Naz; Arslan, Yusuf; Süleyman, Zeynep; Süleyman, Halis

doi:10.4196/kjpp.2021.25.1.69

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…Propofol supplied at a dose of 50 mg/kg for a long period raised the level of malondialdehyde (MDA), which has an oxidant impact on muscle tissue, and lowered the amount of total glutathione (tGSH), which is an antioxidant, according to a recent experimental research. Furthermore, it was reported that administering twice the high dose of propofol raised the level of MDA in muscle tissue in a short period of time and decreased the amount of tGSH (Erdem et al 2021).…”

Section: Introductionmentioning

confidence: 99%

The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

Delen¹,

Dişli²,

Taş³

et al. 2022

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Propofol may cause an increase in reactive oxygen species in the body. In this study, we tested the effect of antioxidant thiamine pyrophosphate (TPP) on propofol-induced liver damage. The eighteen rats were split into three groups: HG, healthy; PP, propofol-treated (50 mg/kg) and PT, treated with propofol (50 mg/kg) and TPP (25 mg/kg). Total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) levels were tested together with aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and malondialdehyde (MDA). Histopathological examination of the tissues was performed. We have found that levels of MDA, TOS, ALT, AST, and LDH were all higher in PP group than in HG and PT groups (p < 0.05). In PP group, the TAS and tGSH levels were statistically substantially lower. The PT for oxidants levels showed a statistically significant reduction. In PT group, the levels of antioxidants were found to be considerably higher. The epitheliums, glands, and vascular structures of the PTs were histologically close to normal. By boosting antioxidants, TPP may help to reduce propofolinduced liver damage.

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Section: Introductionmentioning

confidence: 99%

The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

Delen¹,

Dişli²,

Taş³

et al. 2022

gpb

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“…Another study showed that ATP has a protective effect by preventing the increase in MDA and TOS levels induced by methanol in the optic nerve tissue and also preventing a decrease in the tGSH and TAS levels [30]. Similarly, in a recent study, ATP improved propofol-induced myopathy and reduced oxidative damage [31].…”

Section: Discussionmentioning

confidence: 90%

Adenosine Triphosphate Exerts Cardioprotective Effect on High-Dose Atorvastatin-Induced Heart Damage in Rats

Coskun

2022

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Atorvastatin is a statin derivated hypolipidemic drug used in the treatment of hyperlipidemia. High-dose atorvastatin has been shown to significantly reduce adenosine triphosphate (ATP) levels in the heart tissue. Reduction of ATP by atorvastatin causes increased production of reactive oxygen species (ROS), decreased antioxidants, subsequent cell membrane and mitochondrial damage. The present study aimed to biochemically investigate the protective effect of ATP against possible cardiac damage caused by high dose atorvastatin in rats. Male Wistar rats were divided into atorvastatin (ATR), atorvastatin+ATP (AAT) and healthy control (HG) groups. ATP at a 25 mg/kg dose was injected intraperitoneally (ip) to the AAT (n-6) group. 0.9% NaCl as solvent was applied to the ATR (n-6) and HG (n-6) groups by the same route. Afterward, atorvastatin was administered orally at a dose of 20 mg/kg to the AAT and ATR groups. This procedure was repeated once daily for four weeks. At the end of this period, blood samples were taken into tubes to analyze troponin-I (TP-I) by cardiac puncture before animals were sacrificed with high-dose anesthesia. In addition, heart tissues were removed and malondialdehyde (MDA), total glutathione (tGSH), total oxidant (TOS) and total antioxidant (TAS) levels were measured. Biochemical test results showed that in the heart tissues of the ATR group, the oxidative parameters MDA and TOS significantly increased, while the antioxidant parameters tGSH and TAS significantly decreased compared to AAT and HG. Atorvastatin alone administration significantly increased blood TP-I levels, a marker of cardiac tissue damage. However, ATP administration to AAT group animals brought oxidative parameter levels closer to HG, despite high-dose atorvastatin treatment. In addition, the significant decrease in antioxidant levels was prevented by ATP application. High doses of atorvastatin can cause heart damage. ATP treatment was able to prevent atorvastatin-induced oxidative heart damage.

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“…The ATP 4 mg/kg was injected intraperitoneally (IP) into the AFU group animals (n=6) (Erdem et al, 2021). The same volume of saline (0.9% NaCl) as the solvent was administered IP to the HG (n=6) and FUG (n=6) groups.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Adenosine Triphosphate against 5-Fluorouracil-Induced Oxidative Ovarian Damage in vivo

Özer

İnce

Altuner

et al. 2023

Asian Pac J Cancer Prev

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patients with gastric (Arjmandi et al., 2022), breast, head, neck and other cancers (Grem, 2000). 5-FU has still remained the cornerstone for colorectal cancer chemotherapy (Kobuchi et al., 2020). However, serious side effects and drug resistance phenomenon have limited its clinical use (Ciaffaglione et al., 2021). Serious cardiac side effects including cardiomyopathy, angina pectoris, ventricular tachycardia, heart failure, acute myocardial infarction and cardiogenic shock have been reported in patients treated with 5-FU (Zhang et al., 2018) . Nausea, diarrhea, vomiting, oral and intestinal mucositis, mouth ulcers, anorexia, neutropenia and thrombocytopenia are

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The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation

Cited by 3 publications

References 39 publications

The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

Adenosine Triphosphate Exerts Cardioprotective Effect on High-Dose Atorvastatin-Induced Heart Damage in Rats

Protective Effect of Adenosine Triphosphate against 5-Fluorouracil-Induced Oxidative Ovarian Damage in vivo

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