The effect of adenosine 5′-triphosphate on calcium mobilization and cell proliferation in cervical cancer cells

Lee, Seok-Geun; Choi, Jung-Kyoung; Choi, Byung Hyune; Lim, Yejee; Kim, Young-Hoon; Lee, Kweon-Haeng; Shin, Jong Chul; Ahn, Woong Shick

doi:10.1016/j.ejogrb.2004.07.030

Cited by 7 publications

(11 citation statements)

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“…Under hypoxic conditions, intracellular ATP is secreted to the extracellular space. ATP is a very efficient extracellular distress signal and a key signaling molecule which is involved in various biological processes 32 , 33 . Previous studies have reported that the ability of tumor invasion and metastasis decreases after inhibition of ATP synthesis by tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

et al. 2021

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Melanoma is an aggressive form of skin cancer characterized by rapid invasion and metastasis. CD147 is known to be functioning in cell invasion. In this study, we showed that CD147 was translocated from the cell membrane to the mitochondria in advanced melanoma. Melanoma patients with CD147 localized to the mitochondria confer a worse prognosis. The mitochondrial CD147 levels are correlated with the invasion potential of various melanoma cell lines as well as mitochondrial energy metabolism. Depletion of CD147 decreased the activity of mitochondrial complex V. STRING analysis for protein-protein interaction networks (PPIN) in CD147-depleted melanoma cells showed that mitochondrial proteins HSP60 and ATP5B, a subunit of mitochondrial complex V, were node proteins. HSP60 upregulation was correlated with a worse prognosis of melanoma patients. Co-immunoprecipitation (Co-IP) assay indicates that CD147 interacts with HSP60. These data suggested that mitochondrial CD147 may prompt HSP60 to activate ATP5B, thereby promoting the mitochondrial aerobic oxidation and the invasive abilities of melanoma cells. Correlation analysis of the data acquired from patients was helpful to draw a 5-year survival curve for patients who screened positive and negative for mitochondrial CD147. This study unravels the function of CD147 in tumor invasion and highlights it as a potential tumor therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

et al. 2021

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“…Among the extracellular purines, ATP is a key extracellular signaling molecule and participates in several physiological processes, including immune response, neurotransmission, vascular tonus, pain sensation, cell proliferation, differentiation, development, and death ( Lee et al. , 2006 ; Tamajusuku et al.…”

Section: Introductionmentioning

confidence: 99%

Adenosine uptake is the major effector of extracellular ATP toxicity in human cervical cancer cells

Mello

Filippi-Chiela

Nascimento

et al. 2014

MBoC

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“…O microambiente tumoral do CCU distingue-se, ainda, por apresentar concentrações elevadas de ATP e adenosina -além de outros nucleotídeos -no meio extracelular do microambiente tumoral. Há, dessa forma, a ligação entre o sistema purinérgico e a progressão e persistência das células tumorais (Maldonado et al, 2012). A explicação para esse fato está na importância dos nucleotídeos extracelulares na sinalização molecular de diversos processos biológicos, como a proliferação, a diferenciação e o crescimento celular, bem como a mediação de respostas do sistema imune (Lee et al, 2006).…”

Section: Introductionunclassified

“…Há, dessa forma, a ligação entre o sistema purinérgico e a progressão e persistência das células tumorais (Maldonado et al, 2012). A explicação para esse fato está na importância dos nucleotídeos extracelulares na sinalização molecular de diversos processos biológicos, como a proliferação, a diferenciação e o crescimento celular, bem como a mediação de respostas do sistema imune (Lee et al, 2006). Assim, este capítulo abordará a relação entre os componentes do sistema purinérgico e o desenvolvimento de câncer no colo uterino.…”

Section: Introductionunclassified

Câncer de colo uterino

Pfaffenzeller¹,

Franciosi²,

Cardoso³

2021

Sinalização Purinérgica: Implicações Fisiopatológicas

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All the contents of this work, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 International license. Todo o conteúdo deste trabalho, exceto quando houver ressalva, é publicado sob a licença Creative Commons Atribição 4.0. Todo el contenido de esta obra, excepto donde se indique lo contrario, está bajo licencia de la licencia Creative Commons Reconocimento 4.0.

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The effect of adenosine 5′-triphosphate on calcium mobilization and cell proliferation in cervical cancer cells

Cited by 7 publications

References 24 publications

Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

Adenosine uptake is the major effector of extracellular ATP toxicity in human cervical cancer cells

Câncer de colo uterino

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