The effect of acute respiratory events and respiratory stimulants on EEG-recorded brain activity in neonates: A systematic review

Usman, Fatima; Marchant, Simon; Baxter, Luke; Salihu, Hamisu M.; Aliyu, Muktar H.; Adams, Eleri; Hartley, Caroline

doi:10.1016/j.cnp.2023.11.002

Cited by 3 publications

(3 citation statements)

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“…Although the amplitude of brain activity decreases in some apnoeic episodes compared to periods of normal breathing (Bridgers et al, 1985;Deuel, 1973;Low et al, 2012;Wulbrand and Bentele, 1994), the overall findings of these studies are inconsistent (Usman et al, 2023).…”

Section: Introductionmentioning

confidence: 97%

“…To date, a small number of studies have investigated the effects of apnoeic episodes on brain activity recorded using electroencephalography (EEG) in infants (Usman et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

“…Limited sample sizes (i.e., <10 infants) have precluded investigation of factors which may modulate the effects and explain these inconsistencies (Usman et al, 2023). Whilst long apnoeic episodes can cause complete suppression of cortical activity and severe hypoxia (Low et al, 2012), duration may not be associated with the level of EEG suppression for shorter episodes (Fenichel et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

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Apnoea suppresses brain activity in infants

Zandvoort,

Dereymaeker,

Baxter

et al. 2024

Preprint

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Apnoea – the cessation of breathing – is commonly observed in premature infants. These events can reduce cerebral oxygenation and are associated with poorer neurodevelopmental outcomes. However, relatively little is known about how apnoea and shorter pauses in breathing impact brain function in infants, which will provide greater mechanistic understanding of how apnoea affects brain development. We analysed simultaneous recordings of respiration, electroencephalography (EEG), heart rate, and peripheral oxygen saturation in 124 recordings from 118 infants (post-menstrual age: 38.6 ± 2.7 weeks [mean ± standard deviation]) during apnoeas (pauses in breathing greater than 15 seconds) and shorter pauses in breathing between 5 and 15 seconds. EEG amplitude significantly decreased during both apnoeas and shorter pauses in breathing compared with normal breathing periods. Change in EEG amplitude was significantly associated with change in heart rate during apnoea and breathing pauses and, during apnoeas only, with oxygen saturation change. No associations were found between EEG amplitude and pause duration or post-menstrual age. The decrease in EEG amplitude may be a result of the changing metabolism and/or homeostasis following changes in oxygen and carbon dioxide concentrations, which alters the release of neurotransmitters. As apnoeas often occur in premature infants, frequent disruption to brain activity may impact neural development and result in long-term neurodevelopmental consequences.

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Section: Introductionmentioning

confidence: 97%

“…To date, a small number of studies have investigated the effects of apnoeic episodes on brain activity recorded using electroencephalography (EEG) in infants (Usman et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apnoea suppresses brain activity in infants

Zandvoort,

Dereymaeker,

Baxter

et al. 2024

Preprint

Self Cite

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Correlation between Respiratory Rate and EEG Signals Based on Wireless EEG Acquisition System

Chen,

Lv,

Zhang

et al. 2024

2024 IEEE 4th International Conference on Power, Electronics and Computer Applications (ICPECA)

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Apnoea suppresses brain activity in infants

Zandvoort,

Dereymaeker,

Baxter

et al. 2024

Imaging Neuroscience

View full text Add to dashboard Cite

Apnoea— the cessation of breathing— is commonly observed in premature infants. These events can reduce cerebral oxygenation and are associated with poorer neurodevelopmental outcomes. However, relatively little is known about how apnoea and shorter pauses in breathing impact brain function in infants, which will provide greater mechanistic understanding of how apnoea affects brain development. We analysed simultaneous recordings of respiration, electroencephalography (EEG), heart rate, and peripheral oxygen saturation in 124 recordings from 118 infants (post-menstrual age: 38.6 ± 2.7 weeks [mean ± standard deviation]) during apnoeas (pauses in breathing greater than 15 seconds) and shorter breathing pauses between 5 and 15 seconds. EEG amplitude significantly decreased during both apnoeas and short breathing pauses compared with normal breathing periods. Change in EEG amplitude was significantly associated with change in heart rate during apnoea and short breathing pauses and, during apnoeas only, with oxygen saturation change. No associations were found between EEG amplitude changes and apnoea/pause duration, post-menstrual age, or sleep state. As apnoeas often occur in premature infants, frequent disruption to brain activity may impact neural development and result in long-term neurodevelopmental consequences.

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The effect of acute respiratory events and respiratory stimulants on EEG-recorded brain activity in neonates: A systematic review

Cited by 3 publications

References 59 publications

Apnoea suppresses brain activity in infants

Apnoea suppresses brain activity in infants

Correlation between Respiratory Rate and EEG Signals Based on Wireless EEG Acquisition System

Apnoea suppresses brain activity in infants

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