The effect of acute or long-term genistein administration on the ischemia/reperfusion-induced arrhythmia in rats

Abstract

The cardiovascular disease and sudden death due to the occlusion of coronary artery increases in women after menopause. In this study, it was aimed to research the effect of genistein that has been used to decrease the symptom of menopause in women, on the ischemia reperfusion induced arrhythmias. 64 Female and 12 male, 6-7months old Sprague Dowley rats were used in this study. Genistein was applied daily for four weeks in 100ug/kg dose intraperitoneally in one group and acutely in other group, before reperfusion in 1mg/kg dose intravenously. Six minutes myocardial ischemia were produced by the ligation of ramus interventricularis branch of left coronary artery (LAD) and six minutes of reperfusion by releasing of this artery. The type and duration of arrhythmias and the blood pressure recorded in every group during ischemia and reperfusion were analyzed and compared by using one-way ANOVA test and the incidence of arrhythmia and the survival rate by Ki square test. Genistein had no effect on the ischemia and reperfusion induced arrhythmias in male and ovariectomized female rats.

Therapeutic potentials of genistein: New insights and perspectives

“…shows estrogenic effects and increases the contraction of myocardium (Bozdogan et al, 2018). Studies revealed that genistein reduces hypoxia-induced cardiac injuries.…”

“…In postmenopausal women, level of estrogen declines which leads to the elevated risks of heart diseases (Thangavel et al, 2019). Several studies have revealed that genistein reduces the risk of cardiogenic diseases in women after the postmenopausal period because genistein is a phytoestrogen and possesses estrogen‐like properties, can bind with estrogen receptors (Bozdogan et al, 2018). Therefore, genistein reduces the menopausal symptoms, risk of heart failure and improves the cardiac function with minor or no adverse effects (Thangavel et al, 2019).…”

“…Therefore, genistein reduces the menopausal symptoms, risk of heart failure and improves the cardiac function with minor or no adverse effects (Thangavel et al, 2019). At high dose, genistein shows anti‐estrogenic effects and reduces the myocardial contractility while at low dose, it shows estrogenic effects and increases the contraction of myocardium (Bozdogan et al, 2018). Studies revealed that genistein reduces hypoxia‐induced cardiac injuries.…”