The effect of acute nicotine administration on plasma levels of the thyroid hormones and corticosterone in the rat

Effect of prenatal or perinatal nicotine exposure on neonatal thyroid status and offspring growth in rats

“…These findings support the claim that infant thyroid function was not compromised by the nicotine in cigarettes smoked by pregnant women (Hannigan et al, 1995); and are in agreement with a previous report demonstrating that nicotine did not affect the level of serum T4, T3 and thyrotropin (TSH) in a rat model system (Cam and Bassett, 1983;Colzani et al, 1998). Clinically, smoking during pregnancy has been reported to lead to an enlargement of the thyroid gland.…”

Chronic Nicotine Self-Administration Augments Hypothalamic–Pituitary–Adrenal Responses to Mild Acute Stress

“…In contrast, chronic nicotine SA did not affect the hormonal response to endotoxin (LPS) or immobilization stress. Nicotine is a potent stimulus for the stress-responsive HPA axis that elicits the release of the stress hormones, ACTH (Cam and Bassett, 1983b;Matta et al, 1987) and CORT (Balfour et al, 1975;Cam and Bassett, 1983a). We have previously identified a polysynaptic pathway through which nicotine acutely stimulates the HPA axis (Matta et al, 1998).…”

“…In animal studies, many laboratories, including ours, have reported that nicotine, the main psychoactive component of cigarettes, is a potent stimulus for the secretion of stressresponsive hormones, such as adrenocorticotropic hormone (ACTH) (Cam and Bassett, 1983b;Conte-Devolx et al, 1981;Matta et al, 1987), prolactin (Andersson et al, 1983;Sharp and Beyer, 1986), and corticosterone (CORT) (Balfour et al, 1975;Cam and Bassett, 1983a). We further demonstrated that nicotine indirectly induces ACTH secretion from the anterior pituitary by directly activating noradrenergic areas of the nucleus tractus solitarius (Matta et al, 1998;Zhao et al, 2007).…”

Plasma corticosterone in the rat in response to nicotine and saline injections in a context previously paired or unpaired with nicotine

“…Investigators have also found that repeated nicotine administrations may lead to the development of tolerance to the CORT-elevating effect of nicotine (e.g., Cam and Bassett 1983). For example, Pauly et al (1992) found that a nicotine injection increased CORT levels to a lesser extent in nicotine-experienced than in nicotine-naïve mice.…”