The effect of acute exercise on undercarboxylated osteocalcin in obese men

Levinger, Itamar; Zebaze, Roger; Jerums, George; Hare, David; Selig, Steve E; Seeman, Ego

doi:10.1007/s00198-010-1370-7

Cited by 75 publications

(88 citation statements)

References 24 publications

(32 reference statements)

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“…In the subgroup with diabetes, the increased percentage of undercarboxylated osteocalcin was the main predictor of the reduction of glucose levels after exercise. These results suggested that improvement of glucose metabolism after exercise could be partly explained by the increase of undercarboxylated osteocalcin (45).…”

Section: Human Studies Involving Undercarboxylated Osteocalcinmentioning

confidence: 78%

Osteocalcin, energy and glucose metabolism

Zanatta

Boguszewski

Borba

et al. 2014

Arq Bras Endocrinol Metab

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Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Further studies are required to elucidate the role of osteocalcin in the regulation of glucose and energy metabolism in humans and its potential therapeutic implications in diabetes, obesity and metabolic syndrome. Arq Bras Endocrinol Metab. 2014;58(5):444-51 Keywords Osteocalcin; undercarboxylated osteocalcin; metabolic syndrome; glucose; energy metabolism; diabetes; obesity; leptin; insulin; adiponectin RESUMO A osteocalcina é uma proteína da matriz óssea que tem sido implicada com várias ações hormonais relacionadas à homeostase de glicose e ao metabolismo energéti-co. Modelos animais e experimentais têm demonstrado que a osteocalcina é liberada do osso para a circulação sanguínea e age nas células betapancreáticas e no tecido adiposo. A osteocalcina decarboxilada é a isoforma hormonalmente ativa e estimula a secreção e sensibilidade à insulina no tecido adiposo e muscular. A insulina e a leptina, por sua vez, atuam no tecido ósseo modulando a secreção da osteocalcina, formando uma alça de retroalimentação tradicional em que o esqueleto torna-se um órgão endócrino. Novos estudos ainda são necessários para elucidar o papel da osteocalcina na regulação glicêmica e no metabolismo energético em humanos, com potenciais implicações terapêuticas no tratamento de diabetes, obesidade e síndrome metabólica. Arq Bras Endocrinol Metab. 2014;58(5):444-51 Descritores

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Section: Human Studies Involving Undercarboxylated Osteocalcinmentioning

confidence: 78%

Osteocalcin, energy and glucose metabolism

Zanatta

Boguszewski

Borba

et al. 2014

Arq Bras Endocrinol Metab

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“…Human interventions to increase osteocalcin serum levels have been tested indirectly. In a pilot study in obese patients submitted to either an aerobic or a power acute exercise (39), the reduction in serum glucose post-acute exercise at 2 h was correlated with the percentage change of uncarboxylated osteocalcin, especially in the aerobic program. In addition, a post hoc analysis of the PaTH study (PTH 1-84 vs alendronate) showed that higher increase in uncarboxylated osteocalcin at 3 month was associated with higher increase in adiponectin and greater decrease in body weight and fat mass at 1 year (40).…”

Section: European Journal Of Endocrinologymentioning

confidence: 97%

Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

Confavreux¹,

Szulc²,

Casey³

et al. 2014

European Journal of Endocrinology

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Background: Bone has emerged as an endocrine organ regulating energy metabolism through secretion of osteocalcin. In epidemiological studies, presence of metabolic syndrome (MetS) was associated with lower osteocalcin level. Objectives: We evaluated whether osteocalcin level was associated with MetS severity in men and whether it was more strongly associated with MetS compared with N-terminal propeptide of type I procollagen (PINP), bone-specific alkaline phosphatase (BAP), and C-terminal telopeptide of type I collagen (bCTX). Methods: We included 798 men aged 51-85 years for total osteocalcin measurement. Number of MetS criteria was used to define severity. We used polytomous logistic regression to assess the relationship between MetS severity and osteocalcin level. Results: Thirty percent of men had MetS. In patients with MetS, the higher the number of MetS traits were present, the lower was the average osteocalcin level (0-2 criteria: 551 men: 19.5G6.7 ng/ml, three criteria: 155 men: 19.3G7.4 ng/ml, four criteria: 72 men: 17.3G5.7 ng/ml, and five criteria: 20 men: 15.0G5.1 ng/ml; P for trendZ0.002). In the polytomous logistic regression model, an increase in osteocalcin level of 10 ng/ml was associated with lower prevalence of severe MetS: three criteria (odds ratio (OR)Z0.93 (0.70-1.24)), four criteria (ORZ0.54 (0.34-0.84)), and five criteria (ORZ0.28 (0.10-0.82)) in comparison with no MetS (P for trendZ0.008). After adjustment, using stepwise analysis of the polytomous logistic regression model, we observed that osteocalcin, age, and apparent free testosterone entered in the model but not other bone markers (PINP, bCTX, and BAP). Conclusion: In older Caucasian men, total osteocalcin level was associated with MetS severity. Osteocalcin was more strongly associated with MetS severity than other bone turnover markers.

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“…In non-diabetic adults, weight loss associated with diet and exercise also increased osteocalcin levels in parallel with a decrease in visceral fat and improved insulin sensitivity [50]. Interestingly, acute aerobic, but not power exercise could increase serum ucOC in obese individuals [51].…”

Section: Clinical Relevance Of the Osteocalcin-mediated Regulation Ofmentioning

confidence: 99%

The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism

2011

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Bone remodelling, which maintains bone mass constant during adulthood, is an energy-demanding process. This, together with the observation that the adipocyte-derived hormone leptin is a major inhibitor of bone remodelling, led to the hypothesis that bone cells regulate energy metabolism through an endocrine mechanism. Studies to test this hypothesis identified osteocalcin, a hormone secreted by osteoblasts, as a positive regulator of insulin secretion, insulin resistance and energy expenditure. Remarkably, insulin signalling in osteoblasts is a positive regulator of osteocalcin production and activation via its ability to indirectly enhance bone resorption by osteoclasts. In contrast, leptin is a potent inhibitor of osteocalcin function through its effect on the sympathetic tone. Hence, osteocalcin is part of a complex signalling network between bone and the organs more classically associated with the regulation of energy homeostasis, such as the pancreas and adipose tissue. This review summarises the molecular and cellular bases of the present knowledge on osteocalcin biology and discusses the potential relevance of osteocalcin to human metabolism and pathology.

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The effect of acute exercise on undercarboxylated osteocalcin in obese men

Abstract: This study reports that the reduction in serum glucose post-acute exercise (especially aerobic exercise) may be partly related to increased unOC.

Cited by 75 publications

References 24 publications

Osteocalcin, energy and glucose metabolism

Osteocalcin, energy and glucose metabolism

Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism

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