The effect of acute complicated appendicitis on liver function test

Abstract

Objectives: To determine the diagnostic role of hyperbilirubinemia in acute appendicitis like suppurative and gangrenous appendicitis.
 Methods: This observational study was conducted at Ward-3, Jinnah Postgraduate Medical Center (JPMC), Karachi from 1st June 2019 to 1st June 2020. Males and females above 12 years of age were included. Serum liver function tests and leukocyte counts were carried out. Appendectomies were done, the operative findings and histopathology reports were noted. Hyperbilirubinemia was related with the stages of appendicitis. Results were analyzed by SPSS version 25.
 Results: There were one hundred twenty patients. Thirty-eight (31.66%) were females and eighty-two (68.33%) were males. Age range was 13 to 60 years. Ten patients (8.33%) were between 13 – 20 years, sixty five (54.16%) were 21 to 30 years, thirty (25%) were 31 – 40 years, ten (8.33%) were 41 – 50 years and five patients (4.17%) were above 50 years of age. Sixty-two (51.66%) patients had simple appendicitis and fifty-four (45%) had complicated appendicitis like suppurative (26.66%) and (16.66%) gangrenous appendicitis. Negative appendectomy was found in four (3.33%). Hyperbilirubinemia was found (100%) in gangrenous, (94.12%) in suppurative and (12.3%) in catarrhal appendicitis. Enzymes like Alanine transaminase and Aspartate transaminase were raised (50%) in gangrenous, (50%) in suppurative and (9.67%) in catarrhal appendicitis. TLC was raised in 112 (96.55%) out of 116 patients and total leukocyte count was normal in negative appendectomies.
 Conclusions: It is concluded that hyperbilirubinemia is strong diagnostic predictor for complicated appendicitis.\
 doi: https://doi.org/10.12669/pjms.37.2.3356
 How to cite this:MoulaBux K, Parveen S, Iqbal M, Mehboob A. The effect of acute complicated appendicitis on liver function test. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3356
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Serum bilirubin as a diagnostic marker in acute appendicitis

“…[12] Salvatore Giordano et al, observed that the hyperbilirubinemia (cut-off 1 mg/dl) for prediction of perforation in acute appendicitis, sensitivity of 0.49, specificity of 0.82, positive likelihood ratio of 2.51, negative likelihood ratio of 0.58, diagnostic odds ratio of 4.42. [13]KulsoomMoulaBux et al, studied all the liver function test, of which the serum bilirubin levels independent predictors of appendix perforation/gangrene. [14] A C Chambers et al, concluded that the serum bilirubin levels were significantly higher among the gangrene/perforation, but it cannot be an independent predictor of neither the diagnosis nor the complications of the acute appendicitis.…”