The Effect of Active and Passive Household Cigarette Smoke Exposure on Pregnant Women With Asthma

Newman, Roger B.; Momirova, Valerija; Dombrowski, Mitchell P.; Schatz, Michael; Wise, Robert A.; Landon, Mark B.; Rouse, Dwight J.; Lindheimer, Marshall D.; Caritis, Steve N.; Sheffield, Jeanne S.; Miodovnik, Menachem; Wapner, Ronald J.; Varner, Michael W.; OʼSullivan, Mary J.; Conway, Deborah L.

doi:10.1378/chest.09-0942

Cited by 39 publications

(26 citation statements)

References 28 publications

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“…Females with asthma smoke with the same frequency as nonasthmatics, and asthma did not promote the role of smoking (if anything, impairment of reproductive outcomes was lower among asthmatics), which coincides with the findings of a recent study of a large population of asthmatic mothers [12]. It is important to note that the females in our study were selected from the general population (i.e.…”

Section: Discussionsupporting

confidence: 89%

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Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma

Sunyer

Garcia-Esteban

Castilla³

et al. 2012

Eur Respir J

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Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth weight. One issue that has not been clarified previously is that of the potential higher risk of this outcome in mothers with asthma. We assessed the role of prenatal maternal tobacco use and SHS on reproductive outcomes and assessed the interaction with maternal history of asthma.Data was collected from the INMA study, a maternal birth cohort selected from the general population established in Spain in 2002. We measured cotinine at the 32nd week of pregnancy in 2,219 females. Diagnosed maternal asthma was self-reported during pregnancy.35% of mothers reported not being exposed to smoking or SHS during pregnancy. Active smoking (i.e. self-reported or cotinine .50 ng?mL ) was related to a 134 g decrease in birth weight and a relative risk of 1.8 for small for gestational age and fetal growth restriction. These results were not modified by maternal asthma. Maternal asthma had a similar frequency in all exposure groups. Non SHS-exposed females had the lowest prevalence of asthma. SHS (i.e. cotinine 20-50 ng?mL -1 ) decreased birth weight by 32 g among those without maternal asthma, but these differences were not statistically significant (95% CI -88.76-24.76). Maternal asthma did not promote these effects. Maternal history of asthma did not modify the effects of smoking on reproductive outcomes in a cohort sampled from the general population.

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Section: Discussionsupporting

confidence: 89%

“…Females with asthma had a higher rate of low birth weight babies and preterm delivery than those without asthma [10,11]. The largest prospective study conducted in pregnant females with asthma did not find a significant risk of SHS on fetal growth abnormalities [12].…”

mentioning

confidence: 85%

Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma

Sunyer

Garcia-Esteban

Castilla³

et al. 2012

Eur Respir J

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“…Moreover, cigarette smoking in asthma is associated with higher frequency of exacerbations [21], increased numbers of life threatening asthma attacks [22], and asthma mortality is greater among heavy smokers with asthma compared to asthmatics who do not smoke [23]. During pregnancy, exacerbations are more common and more severe in current smokers than never-smokers with asthma [49] and fetal growth abnormalities are more common [50].…”

Section: Smoking As a Risk Factor For The Development Of Asthmamentioning

confidence: 99%

Smoking and asthma: dangerous liaisons

2012

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Cigarette smoking and asthma interact to induce important adverse effects on clinical, prognostic and therapeutic outcomes. This review examines recent evidence on the harmful effects of smoking in asthma, possible underlying inflammatory mechanisms for this altered response, management options for these patients and potential future therapeutic directions. Active smokers, particularly females, are at risk of developing asthma. Prevalence rates for smoking in asthma are relatively close to those found in the general population. Smokers with asthma experience worse asthma control than nonsmokers with asthma. Mechanisms for the adverse effects of smoking in asthma include altered airway inflammation and corticosteroid insensitivity. Quitting smoking can improve symptoms and lung function, but the low rates of smoking cessation highlights the need for improved strategies for managing these patients. Clinical trials assessing new therapies for asthma need to enrol smokers to identify treatments that are effective in the asthma smoking phenotype.

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“…The most common methods of measuring SHS exposure among pregnant women have been a single question about partner smoking status or the number of cigarettes smoked by the partner (see Windham, Eaton, and Hopkins, 1999, review). When studies of pregnant smokers have included other questions, they consist of either a question about number of smokers in the household or hours of exposure to SHS (Leonardi-Bee et al, 2008;Newman et al, 2010;Pogodina, Brunner Huber, Racine, and Platonova, 2009;Windham et al). Few prospective studies of maternal cigarette smoking during pregnancy have examined ongoing SHS exposure using more than single indicator measures of SHS exposure, although studies of postnatal SHS exposure or lifetime SHS exposure have more comprehensive measures (e.g., Edwards, 2009;Rise and Lund, 2005).…”

Section: Introductionmentioning

confidence: 99%

Sources and Frequency of Secondhand Smoke Exposure During Pregnancy

Eiden¹,

Molnar

Leonard

et al. 2011

Nicotine & Tobacco Research

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Introduction: This study examined sources of exposure to secondhand smoke (SHS) during pregnancy and misclassification of women as having no SHS exposure if partner smoking was used as the only measure of SHS exposure. We also examined changes in SHS exposure across the three trimesters of pregnancy. Methods:The sample consisted of 245 pregnant women who were in a serious relationship with a partner and 106 for examination of change over time. Women's smoking status was determined by a combination of self-reports and oral fluid assays. Women's reports of partner smoking, smoking by other social network members, and frequency of exposure to SHS were obtained. Results:The most common source of SHS exposure during pregnancy was the partner (n = 245). However, reliance on the partner smoking measure alone would have misclassified a substantial number of women as having no SHS exposure during pregnancy. The importance of exposure from the general social network was also evident in the finding that among nonsmoking women with nonsmoking partners, 50% reported some level of SHS exposure in the preceding week. Contrary to expectations, there were no changes in SHS exposure across the three trimesters of pregnancy (n = 106). Conclusions:Results highlight the need for treatment plans to target sources of exposure from other members of women's social networks in addition to partners. It may be unrealistic to expect women's cessation efforts to be successful in the face of consistent and continued SHS exposure through pregnancy. IntroductionResults from studies focusing on maternal exposure to secondhand smoke (SHS) during pregnancy suggest that there may be

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The Effect of Active and Passive Household Cigarette Smoke Exposure on Pregnant Women With Asthma

Cited by 39 publications

References 28 publications

Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma

Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma

Smoking and asthma: dangerous liaisons

Sources and Frequency of Secondhand Smoke Exposure During Pregnancy

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