The Effect of ACTH4-10 synthetic on separated junction formation and CSF leukocyte number in LPS-induced meningitis

Abstract

: Mortality and morbidity

Effect of ACTH4-10pro8-gly9-pro10 on malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2a expression in rat spinal cord injury

“…From the above data, the mild and severe ASCI given ACTH4-10Pro8-Gly9-Pro10 showed a decreased F2-isoprostane expression, which was lower and statistically significant compared to the group given 0.9 % NaCl. The findings from our study support the previous research by Erny et al, which demonstrated that ACTH4-10 administration can reduce the level of prostaglandin E2 associated with NFkB caused by transcription factors (19).…”

“…To date, no data or reports regarding serious side effects from its use (9). ACTH4-10 administration is known to reduce the apoptosis rate of neuron cells in acute spinal cord compression injury in Sprague-Dawley rats by increasing the Bcl-2/HSP70 ratio (10). Other studies show that giving ACTH4-10 can also reduce pro-inflammatory mediators TLR-2, NF-kB, IL-8, and TNF-α in Sprague-Dawley rats treated with acute spinal cord compression injury (11).…”