The Effect of Acidosis on the Ecg of the Rat Heart

Aberra, A.; Komukai, Kimiaki; Howarth, Frank Christopher; Orchard, Clive H.

doi:10.1113/eph8602051

Cited by 28 publications

(23 citation statements)

References 10 publications

(11 reference statements)

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“…This mechanism may account for the ECG changes we observed during the experiment [4]. As in our study, Aberra [8] reported PR prolongation in an in vitro isolated rat heart model with acidosis, resulting in similar finding as our study. However, the model was exposed to a pH of 6.5 which is much lower than the lowest serum pH, in our study, which was of 7.2.…”

Section: Discussionsupporting

confidence: 81%

Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

et al. 2012

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Cyanide causes severe cardiac toxicity resulting in tachycardia, hypotension, and cardiac arrest; however, the clinical diagnosis can be difficult to make. A clinical finding that may precede or predict cyanide-induced hypotension may be a trigger to provide treatment earlier and improve outcomes in cyanide toxicity. Our primary objective was to determine if there is a clinically significant change in ST segment deviation measured on ECG during intravenous cyanide infusion that may predict cyanide-induced hypotension. As part of a larger study comparing antidotes for cyanide-induced shock, 30 swine were anesthetized and monitored and then intoxicated with a continuous cyanide infusion until severe hypotension (50 % of baseline mean arterial pressure) occurred. ECGs were obtained at baseline, every 5 min during infusion, and at the development of hypotension. Repeated measures of analysis of variance were used to determine significance. The mean weight for the 30 swine at baseline was 48 kg (range 45-52), pulse rate 86 beats/min (range 55-121), and systolic blood pressure 109 mmHg (range 90-121). The mean time to hypotension was 31 min (range 16-39). The mean amount of cyanide infused was 5 mg/kg (range 2.5-6.3 mg/kg). All animals (30/30) had ECG changes in repolarization or depolarization during cyanide infusion. Significant rhythm, repolarization, and conduction changes from baseline were observed prior to severe hypotension (p<0.05). Normal sinus rhythm and sinus tachycardia were the most common rhythms preceding hypotension. We observed ST segment elevation in leads V3, V4, III, and aVF and ST segment depression in leads aVL and aVR. The most pronounced ST segment elevation was observed in leads V3 and V4. We also detected significant changes with increased pulse rate, prolonged PR interval, and shortened QTc interval. Other significant changes were increased T axis and reduced QRS axis. We detected ST segment deviations occurring just before the onset of cyanide-induced hypotension in our swine model. Leads V3 and V4 had the most pronounced with ST elevation, but we also detected electrocardiographic ST elevation inferiorly. Shortening of the QTc and lengthening of the PR interval were also detected before hypotension.

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Section: Discussionsupporting

confidence: 81%

Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

et al. 2012

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“…There was an age-dependent decrease in NHE1 (Na + -H + exchanger) in the SAN. NHE1 plays an important role in the regulation of intracellular pH and, therefore, the decrease could inhibit the ability of aged SAN cells to extrude protons, and this could lead to an intracellular acidosis, which has been reported to decrease the heart rate (Aberra et al 2001). There was an age-dependent increase in NBC1 in the atrial muscle.…”

Section: Other Age-dependent Changesmentioning

confidence: 66%

Ageing-dependent remodelling of ion channel and Ca²⁺clock genes underlying sino-atrial node pacemaking

Tellez

Mączewski

Yanni

et al. 2011

Experimental Physiology

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The function of the sino-atrial node (SAN), the pacemaker of the heart, is known to decline with age, resulting in pacemaker disease in the elderly. The aim of the study was to investigate the effects of ageing on the SAN by characterizing electrophysiological changes and determining whether changes in gene expression are involved. In young and old rats, SAN function was characterized in the anaesthetized animal, isolated heart and isolated right atrium using ECG and action potential recordings; gene expression was characterized using quantitative PCR. The SAN function declined with age as follows: the intrinsic heart rate declined by 18 ± 3%; the corrected SAN recovery time increased by 43 ± 13%; and the SAN action potential duration increased by 11 ± 3% (at 75% repolarization). Gene expression in the SAN changed considerably with age, e.g. there was an age-dependent decrease in the Ca 2+ clock gene, RYR2, and changes in many ion channels (e.g. increases in Na v 1.5, Na v β1 and Ca v 1.2 and decreases in K v 1.5 and HCN1). In conclusion, with age, there are changes in the expression of ion channel and Ca 2+clock genes in the SAN, and the changes may provide a partial explanation for the age-dependent decline in pacemaker function.

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“…In 1 animal study with dogs, increased susceptibility of the heart to ventricular fibrillation was found during metabolic acidosis [13]. In another animal study with rats, the authors concluded that acidosis produced a marked decrease in heart rate and an increase in P-R interval with no apparent effect on the duration of the QRS complex [14].…”

Section: Discussionmentioning

confidence: 85%

Impact of methanol intoxication on the human electrocardiogram

et al. 2014

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The Effect of Acidosis on the Ecg of the Rat Heart

Cited by 28 publications

References 10 publications

Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

Ageing-dependent remodelling of ion channel and Ca²⁺clock genes underlying sino-atrial node pacemaking

Impact of methanol intoxication on the human electrocardiogram

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The Effect of Acidosis on the Ecg of the Rat Heart

Cited by 28 publications

References 10 publications

Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

Acute Electrocardiographic ST Segment Elevation May Predict Hypotension in a Swine Model of Severe Cyanide Toxicity

Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking

Impact of methanol intoxication on the human electrocardiogram

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Ageing-dependent remodelling of ion channel and Ca²⁺clock genes underlying sino-atrial node pacemaking