The Effect of Acetylcysteine on Neuropsychiatric Indicators of Rats After Acute Ethanol Intoxication

Морковин, Е. И.; Osadchenko, N.A.; Knyshova, Liliya Petrovna; Бакулин, Д. А.; Куркин, Д. В.

doi:10.19163/1994-9480-2019-3(71)-110-115

Cited by 3 publications

(2 citation statements)

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“…In the framework of the present work, it was found that in the rats that had received NAC before acute ethanol intoxication a decrease in glutathione level in hepatocytes was less pronounced than in the rats that had not received NAC on the background of ethanol intoxication. This is consistent with the results of our previous studies (Kupchik et al 2012, Kurkin et al 2019, Morkovin et al 2019a, in which the therapeutic effects of NAC were evaluated (with a single oral administration after alcohol intoxication). In both cases, the animals were injected intraperitoneally with ethanol, which excluded the pharmacokinetic interaction of NAC with ethanol, which could have contributed to a lower systemic absorption of the latter.…”

Section: Resultssupporting

confidence: 92%

“…The prevalence of alcoholism is one of the central public health problems in medical, social and economic terms. According to the latest WHO data, alcoholism is one of the leading causes of health deterioration worldwide, and the European Region has the highest premature mortality attributed to ethanol consumption (due to an increase in the number of somatic pathologies and death due to alcohol intoxication) (Kupchik et al 2012, Kurkin et al 2019, Morkovin et al 2019a.…”

Section: Resultsmentioning

confidence: 99%

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N-acetylcysteine relieves neurologic signs of acute ethanol hangover in rats

Куркин¹,

Морковин²,

Osadchenko³

et al. 2021

RRP

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Introduction: Alcohol abuse is one of the grave social and medical problems in many countries, including Russia. Alcohol not only negatively affects health, social and family relationships, but also a person’s performance. Hangover, which is a one of the negative consequences of alcohol intake, is a complex of neurological and somatic symptoms that occur when ethanol is almost completely metabolized to acetaldehyde. This condition, despite the severity and potential economic damage, remains poorly understood, and there are no effective medicines to treat it. Aim: to provide an experimental basis for the possibility of using N-acetylcysteine (NAC), a precursor of glutathione, as a medicine for prevention of the neurological and cognitive impairments due to alcohol intoxication. Materials and Methods: The study used male Wistar rats, which were intraperitoneally injected with ethanol at a dose of 3 g/kg to simulate acute ethanol intoxication. Sixty minutes before the injection, the animals from the experimental groups were gavaged with NAC (1 g/kg) or with an equivalent volume of saline. Immediately after awakening and 3 h after it, the animals were assessed for neurological deficits, motor skills, spontaneous motor activity, and cognitive functions. After the completion of the behavioral tests, the animals were euthanized to assess the level of glutathione, triglycerides (TGs), and malonic dialdehyde (MDA) in liver homogenates, and to determine the activity of enzymatic antioxidant systems and serum aminotransferases. Results and Discussion: The ethanol intoxication in the animals from the control group was associated with pronounced signs of neurological and cognitive impairments, including low spontaneous motor and exploratory activity, impaired fine motor skills in the adhesive test, and cognitive function decline in the Morris water maze test. The rats which had received NAC before ethanol injection demonstrated better fine motor skills in the adhesive test, a higher level of spontaneous motor activity and better performance in the Morris water maze test (in comparison to the animals treated with saline before alcohol intoxication). In the animals which had received NAC, the levels of glutathione, MDA, and TGs, as well as the activity of liver antioxidant enzymes, were closer to the values of the intact rats to a greater extent than in the animals that had been injected with ethanol and received saline. Conclusion: Orally administered NAC before acute ethanol intoxication led to a decrease in the severity of neurological deficiency in rats and reduced the amnesic effect of ethanol. This could be due to an improvement of ethanol metabolism and a decrease in the severity of disorders associated with oxidative stress and liver dysfunction.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

N-acetylcysteine relieves neurologic signs of acute ethanol hangover in rats

Куркин¹,

Морковин²,

Osadchenko³

et al. 2021

RRP

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The Study of the Effectiveness of Ethylmethylhydroxypyridine Succinate in Acute Alcohol Intoxication

Shchulkin,

Abalenikhina,

Mylnikov

2024

Bull Exp Biol Med

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Effectiveness assessment of sulfur-containing amino acids in rats with experimental “alcohol withdrawal syndrome” with modified zoosocial interaction methods

Petrov,

Osadchenko,

Tarasov

et al. 2024

Farm. farmakol. (Pâtigorsk)

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The aim of the work was to compare the effects of ademethionine, acetylcysteine and taurine on the zoosocial behavior of rats in a post-intoxicated state after an acute ethanol poisoning.Materials and methods. The study was conducted on male rats of the Wistar line. The post-intoxication state was modeled by a single injection of ethanol (3 g/kg, intraperitoneally). 30 min after awakening, the animals were injected with a physiological solution, acetylcysteine (1 g/kg), ademetionine (100 mg/kg) or taurine (40 mg/kg). A zoosocial interaction test was performed 30 min after the administration.Results. Among the behavioral indicators investigated, the following were validated: the number of acts of freezing, their duration, the number of acts of sniffing in front, the number of acts of avoidance and the number of vertical stances without support (p <0.05 between the values of the negative and positive control groups in all cases). The administration of acetylcysteine, ademetionine and taurine reduced the number of freezing acts by 53.64, 7.27 and 24.51%, respectively (p <0.05 when compared with the indicator index in the animals from the positive control group in all cases). The administration of acetylcysteine and taurine reduced the number of avoidance acts by 50 and 10%, respectively (p <0.05 when compared to that of the animals from the positive control group in both cases). All amino acids normalized the communicative performance, although it did not differ from that of the animals from the positive control group (p >0.05). Alcoholization reduced the number of vertical stances by 65% (p <0.001 when compared with that in the animals from the negative control group), and when followed by the administration of ademetionine and taurine, the reduction was 38 and 36%, respectively (p <0.05 when compared to that in the animals from the negative control group).Conclusion. According to the data obtained, sulfur-containing amino acids, primarily those that had central effects, normalized neuronal functions, positively influencing a complex behavior of rats. Taking into account the results of the previous studies, it was possible to conclude that the therapeutic effect of ademetionine and taurine in the context of a post-intoxication state is mediated by their central effects, which are not so pronounced in comparison with acetylcysteine.

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The Effect of Acetylcysteine on Neuropsychiatric Indicators of Rats After Acute Ethanol Intoxication

Cited by 3 publications

References 0 publications

N-acetylcysteine relieves neurologic signs of acute ethanol hangover in rats

N-acetylcysteine relieves neurologic signs of acute ethanol hangover in rats

The Study of the Effectiveness of Ethylmethylhydroxypyridine Succinate in Acute Alcohol Intoxication

Effectiveness assessment of sulfur-containing amino acids in rats with experimental “alcohol withdrawal syndrome” with modified zoosocial interaction methods

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