The effect of acetate on the production of citric acid by Aspergillus niger in submerged fermentation

A, Nowakowska-Waszczuk; Rubaj, E.; Matusiak, Bartosz; Kosiek, E.

doi:10.1007/bf00261945

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…There are several notable articles on the growth of A. niger and citric acid production (25,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), on either constitutive or heterologous enzyme production (44,45), and on organic acid production (46). Specifically, three articles give insightful overviews of the state of citric acid production at the time they were written (47)(48)(49).…”

Section: Application To Aspergillus Cultivation and Citric Acid Produmentioning

confidence: 98%

“…Addition of acetate Increase in pellet fluffiness 0.2 wt% ammonium acetate, shake flask, A. niger strain R-8 (39) and decrease in pellet size spores/mL, A. niger (83,84) Polymer additives Smaller pellets, eventually PEG20,000: filamentous growth with 20 w/v%, pelleted growth (nonionic PEG20,000 filamentous growth, with 0-10 w/v%; CMC: filamentous growth with 2.0 w/v%, and anionic CMC) reduction in spore pellets formed with 0-1.5 w/v%; different optima for product titer; agglomeration, no exact diameters given; shake flask; 1.3 × 10 6 spores/L inoculum; increase in broth viscosity P. chrysogenum (85) (lower oxygen solubility)…”

Section: Influences On Pellet Formationmentioning

confidence: 99%

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Early phase process scale-up challenges for fungal and filamentous bacterial cultures

Junker

Hesse

Burgess

et al. 2004

Appl Biochem Biotechnol

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Culture pelleting and morphology has a strong influence on process productivity and success for fungal and filamentous bacterial cultures. This impact is particularly evident with early phase secondary metabolite processes with limited process definition. A compilation of factors affecting filamentous or pelleting morphology described in the literature indicates potential leads for developing process-specific control methodologies. An evaluation of the factors mediating citric acid production is one example of an industrially important application of these techniques. For five model fungal and filamentous bacterial processes in an industrial fermentation pilot plant, process development strategies were developed and effectively implemented with the goal of achieving reasonable fermentation titers early in the process development cycle. Examples of approaches included the use of additives to minimize pelleting in inoculum shake flasks, the use of large-volume frozen bagged inoculum obtained from agitated seed fermentors, and variations in production medium composition and fermentor operating conditions. Results were evaluated with respect to productivity of desired secondary metabolites as well as process scalability. On-line measurements were utilized to indirectly evaluate the cultivation impact of changes in medium and process development. Key laboratory to pilot plant scale-up issues also were identified and often addressed in subsequent cultivations.

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Section: Application To Aspergillus Cultivation and Citric Acid Produmentioning

confidence: 98%

Section: Influences On Pellet Formationmentioning

confidence: 99%

Early phase process scale-up challenges for fungal and filamentous bacterial cultures

Junker

Hesse

Burgess

et al. 2004

Appl Biochem Biotechnol

View full text Add to dashboard Cite

show abstract

Citric acid production by surface culture using Aspergillus niger: Kinetics and simulation

Sakurai¹,

Imai²,

Ejiri³

et al. 1991

Journal of Fermentation and Bioengineering

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Effect of operational conditions on the rate of citric acid production by rotating disk contactor using Aspergillus niger

Sakurai

Imai

1992

Journal of Fermentation and Bioengineering

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The effect of acetate on the production of citric acid by Aspergillus niger in submerged fermentation

Cited by 3 publications

References 2 publications

Early phase process scale-up challenges for fungal and filamentous bacterial cultures

Early phase process scale-up challenges for fungal and filamentous bacterial cultures

Citric acid production by surface culture using Aspergillus niger: Kinetics and simulation

Effect of operational conditions on the rate of citric acid production by rotating disk contactor using Aspergillus niger

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