The Effect of a Synthetic Gastrin-Like Pentapeptide (I.C.I. 50,123) on Intestinal Motility in Man

Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

“…The results obtained for our control sub jects agree with previous studies that have shown a stimulating effect of pentagastrin [7,13,24,26] and gastrin [7. 15.…”

Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin.

“…Nine of the 19 tests made with single injections of pentagastrin were accompanied by side effects which occurred over the whole range of dosage used, the frequency and severity increasing with higher doses. The symptoms generally resembled those reported previously by Logan and Connell (1966).…”

“…The physiological actions of pentagastrin closely resemble those of the hormone, but are not identical. The analogue is 11 times less potent on a molar basis as a stimulant of gastric secretion (Barrett, 1966) and side effects can occur from intravenous administration (Wormsley, Mahoney, and Ng, 1966;Logan and Connell, 1966;present results). Although in vitro experiments on human tissue show a close similarity of action between gastrin and the analogue (Bennett, Misiewicz, and Waller, 1967), the extrapolation of present results to gastrin itself should be made with caution.…”

“…In a preliminary study Smith and Hogg (1966) described widespread stimulation of alimentary motility following single intravenous injections of large doses of gastrin II. Logan and Connell (1966) reported that intravenous injections of pentagastrin in doses ranging from 0-25 to 0.5 ,g./kg. given over three minutes sometimes stimulated rectal and sigmoid activity in two of three subjects, although the time interval and magnitude of response could not be related to the dose and inhibition, rather than stimulation, of the sigmoid occurred at times.…”

“…50,123, Peptavlon) have been reported (Smith and Hogg, 1966;Logan and Connell, 1966). It is not yet clear what is the role of the antral hormone in the control of motility in general and of the gastro-colic reflex in particular.…”