The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazole on spatial learning and memory in rats

Göçmez, S.S.; Yazır, Yusufhan; Şahin, Deniz; Karadenizli, Sabriye; Utkan, Tijen

doi:10.1016/j.pbb.2015.01.013

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…However, going against the notion that decreased nNOS-NO production is implicated in exercise-induced BDNF level elevation, cerebral nNOS levels were reported to be higher in exercised than in sedentary rats (Chen & Xiao, 2014). Furthermore, supporting a negligible role of nNOS in the in vivo control of brain BDNF levels, it was recently shown that Morris water maze training-induced BDNF upregulation in the hippocampus was insensitive to nNOS inhibition (Gocmez et al, 2015). With regard to 2VO, its effect on nNOS has to the best of our knowledge never been investigated.…”

Section: Control Of Trkb Receptors By Nomentioning

confidence: 99%

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Banoujaafar

Monnier

Pernet

et al. 2016

Eur J of Neuroscience

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Scientific evidence continues to demonstrate a link between endothelial function and cognition. Besides, several studies have identified a complex interplay between nitric oxide (NO) and brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition. Therefore, this study investigated the link between cerebral endothelium-derived NO and BDNF signaling. For this purpose, levels of BDNF and the phosphorylated form of endothelial NO synthase at serine 1177 (p-eNOS) were simultaneously measured in the cortex and hippocampus of rats subjected to either bilateral common carotid occlusion (n = 6), physical exercise (n = 6) or a combination of both (n = 6) as experimental approaches to modulate flow-induced NO production by the cerebrovasculature. Tropomyosin-related kinase type B (TrkB) receptors and its phosphorylated form at tyrosine 816 (p-TrkB) were also measured. Moreover, we investigated BDNF synthesis in brain slices exposed to the NO donor glyceryl trinitrate. Our results showed increased p-eNOS and BDNF levels after exercise and decreased levels after vascular occlusion as compared to corresponding controls, with a positive correlation between changes in p-eNOS and BDNF (r = 0.679). Exercise after vascular occlusion did not change levels of these proteins. Gyceryl trinitrate increased proBDNF and BDNF levels in brain slices, thus suggesting a possible causal relationship between NO and BDNF. Moreover, vascular occlusion, like exercise, resulted in increased TrkB and p-TrkB levels, whereas no change was observed with the combination of both. These results suggest that brain BDNF signaling may be dependent on cerebral endothelium-derived NO production.

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Section: Control Of Trkb Receptors By Nomentioning

confidence: 99%

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Banoujaafar

Monnier

Pernet

et al. 2016

Eur J of Neuroscience

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“…The percentage of positive cells was defined as (0), <5%; (1), 6% to 15%; (2), 16% to 50%; (3), 51% to 80%; and (4), >80% positive cells. [ 27 ] This analysis was performed on three retinal sections of each rat and the mean value was determined.…”

Section: Methodsmentioning

confidence: 99%

Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model

Kaymaz

Ulaş

Çetinkaya

et al. 2021

Indian Journal of Ophthalmology

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Purpose: Investigating the effects of intraperitoneal carvacrol administration in rats using the oxygen-induced retinopathy (OIR) model. Methods: A total of 28 newborn Sprague Dawley rats were used and the OIR model was created using the 50/10% oxygen model. The study composed of four groups in total. While the OIR model was not used in Group I (control group), it was created for Groups II, III, and IV. About 0.01 mL carvacrol, bevacizumab, or 0.9% NaCl was administered intraperitoneal (IP) to the rats in all groups on postnatal day (PND) 14 as follows: Group I and Group II were administered 0.9% NaCl, Group III was administered bevacizumab, and Group IV was administered carvacrol. On PND 18, rats were sacrificed and their right eyes were enucleated. Results: Histopathological and immunohistochemical studies showed that the number of vascular endothelial cells (VECs), vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) decreased similarly in Group III and Group IV compared with Group II. VECs values for Group I, Group II, Group III, and Group IV were measured as 0 ± 0, 26.45 ± 4.57, 7.75 ± 1.98, and 5.78 ± 1.72, respectively, and it differed significantly between groups ( P < 0.001). Likewise, VEGF levels were observed as 0.06 ± 0.01, 3.31 ± 0.53, 2.47 ± 0.44, and 2.49 ± 0.52, respectively, and it differed significantly between groups ( P < 0.001). TNF-α levels were recorded as 0.06 ± 0.01, 3.58 ± 0.38, 2.46 ± 0.49, and 2.29 ± 0.25, respectively, and it differed significantly between groups ( P < 0.001). VECs, VEGF, and TNF-α were similar between Group III and IV (range of P values were 0.486–0.998). Conclusion: The study demonstrated that carvacrol significantly reduced retinal pathological angiogenesis, NV, VEC nuclei count, VEGF, and TNF-α levels. Moreover, the observed effects were comparable to those of bevacizumab.

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“…The total LA was expressed in terms of the sum of stereotypic, ambulatory, and vertical activities. We monitored the activity for 5 min continuously following acclimatisation to the test room illuminated for a period of one hour with two 36-Watt overhead fluorescent tubes with a light intensity of 18-45 lx on the cage floors and 190-220 lx in the centre of the room (Gocmez et al, 2015[ 16 ]).…”

Section: Methodsmentioning

confidence: 99%

“…We used a circular pool (150 cm in diameter) that was filled with water at 25 °C as the water maze. To make the platform invisible, we placed small white pieces of plastic in the pool (Gocmez et al, 2015[ 16 ]). The pool was situated in a dimly lit soundproof test room along with various extra-maze visual cues.…”

Section: Methodsmentioning

confidence: 99%

Effects of gestational and lactational exposure to low dose mercury chloride (HgCl2) on behaviour, learning and hearing thresholds in WAG/Rij rats

Şahin

Erdolu

Karadenizli

et al. 2016

EXCLI Journal; 15:Doc391; ISSN 1611-2156

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The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazole on spatial learning and memory in rats

Cited by 15 publications

References 34 publications

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model

Effects of gestational and lactational exposure to low dose mercury chloride (HgCl2) on behaviour, learning and hearing thresholds in WAG/Rij rats

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