The effect of a rapid weight loss induced by laparoscopic adjustable gastric banding on arterial stiffness, metabolic and inflammatory parameters in patients with morbid obesity

Shargorodsky, Marina; Fleed, A; Boaz, Mona; Gavish, Dov; Zimlichman, Reuven

doi:10.1038/sj.ijo.0803320

Cited by 39 publications

(22 citation statements)

References 34 publications

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“…Our investigation corroborates preliminary studies (18,(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) as it shows that obesity is a state of chronic low-grade inflammation and the weight reduction resulting from bariatric surgery significantly improves the inflammatory state. This amelioration relies on the continuous reduction in hs-CRP and IL-6 concentrations, associated with a parallel decrease in BMI.…”

Section: Discussionsupporting

confidence: 78%

“…Previous studies have demonstrated that surgically induced weight loss is accompanied by an improvement of the endothelial function (18,19,21) and the proinflammatory state (18,(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). However, few studies have studied endothelial function and proinflammatory state together, and have considered different time-points to determine postsurgical changes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Gómez¹,

Ortega²,

Aragón‐Alonso³

et al. 2016

Nutr Hosp

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Palabras clave:Obesidad. Cirugía bariátrica. Infl amación. Función endotelial. Resistencia a la insulina. ResumenObjetivo: la obesidad está asociada con un aumento del riesgo de enfermedad cardiovascular. Se ha propuesto una relación causal entre obesidad, infl amación, resistencia a la insulina, y disfunción endotelial. El objetivo de este estudio fue valorar marcadores de insulinorresistencia, infl amación y disfunción endotelial en pacientes con obesidad mórbida antes y después de la pérdida de peso por cirugía bariátrica. Métodos: se midieron las concentraciones séricas de moléculas solubles de adhesión intercelular tipo 1 (sICAM-1), inhibidor del activador del plasminógeno tipo 1 (PAI-1), proteína C reactiva de alta sensibilidad (hs-PCR) e interleucina 6 (IL-6) en 79 pacientes con obesidad mórbida antes y a los 3, 6 y 12 meses de la realización de un by-pass gástrico. También se evaluaron índices de resistencia a la insulina. Resultados: a los 12 meses de la cirugía disminuyeron los niveles de sICAM1 (p < 0,001), PAI-1 (p < 0,05), hs-CRP (p < 0,001), IL-6 (p < 0,001) y el índice homeostasis model assessment (HOMA) (p < 0,001) y aumentó el índice McAuley (p < 0,001). Los niveles basales de hs-PCR estaban correlacionados con los de sICAM-1 (r = 0,450, p < 0,01) y de IL-6 (r = 0,451, p < 0,01). También existía correlación entre el descenso de los niveles de PAI-1 y el descenso de hs-PCR (r = 0,425, p < 0,01) y triglicéridos (r = 0,351, p < 0,01). Conclusiones: en pacientes con obesidad mórbida una importante pérdida de peso por cirugía bariátrica se acompaña de una mejora signifi cativa de marcadores infl amatorios, de función endotelial e insulinorresistencia, lo que puede suponer una disminución del riesgo cardiovascular. Existe una relación entre mejora del perfi l infl amatorio y función endotelial. AbstractObjective: Obesity is associated with a high risk for atherosclerotic cardiovascular disease. There is a causal association between obesity, infl ammation, insulin resistance (IR) and endothelial dysfunction. The aim of this study was to evaluate changes in IR, proinfl ammatory state and markers of endothelial dysfunction in morbidly obese patients after weight loss following bariatric surgery. Methods: In this study, we measured the levels of soluble intracellular adhesion molecule-1 (sICAM1), plasminogen activator inhibitor 1 (PAI-1), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) in 79 morbidly obese patients at baseline and 3, 6 and 12 months after gastric bypass. Also, we evaluated changes in IR. Results: Twelve months after surgery, there was a signifi cant decrease in plasma levels of sICAM1 (p < 0.001), PAI-1 (p < 0.05), hs-CRP (p < 0.001), IL-6 (p < 0.001) and homeostasis model assessment (HOMA) (p < 0.001) and a signifi cant increase of McAuley index (McAuley) (p < 0.001). Baseline levels of hs-PCR were positively correlated with sICAM-1 (r = 0.450, p < 0.01) and IL-6 (r = 0.451, p < 0.01). Signifi cant correlations were also found between the decrease of PAI-1 and the ...

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Gómez¹,

Ortega²,

Aragón‐Alonso³

et al. 2016

Nutr Hosp

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“…From prior studies, it appears that weight loss of >7% may improve arterial stiffness and BP. This amount of weight loss was also associated with improvement in lipid profile, inflammatory markers, and insulin sensitivity [7,22,37] achieved by a regimented nutritional and exercise intervention program [6]. Despite the improvement in hsCRP and insulin parameters, it is possible that the small weight loss achieved in this study and lack of improvement in lipid profile were not sufficient to improve arterial stiffness in our study.…”

Section: Discussioncontrasting

confidence: 45%

Improved insulin sensitivity, central systolic pressure and inflammatory indicators achieved with minor weight reduction in overweight and obese subjects given education on lifestyle modification

et al. 2014

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Background: Obesity is a global epidemic disease; lifestyle modification is an approach in the prevention and management of obesity. Objective: We determined the effects of education on modified lifestyle intervention on arterial stiffness, metabolic and inflammatory markers. Methods: Twenty-five generally healthy overweight and obese subjects completed nine months education on modified lifestyle intervention at Hospital Universiti Sains Malaysia, Kota Bharu. Subjects were regularly counselled to increase physical activity and modify their diet during intervention. Arterial stiffness was measured noninvasively using carotid femoral pulse wave velocity (PWV) and pulse wave analysis (PWA). Anthropometric measurements, body fat percentage and visceral fat, central and brachial blood pressures, lipid profile, the inflammatory marker high sensitivity C-reactive protein (hsCRP) and insulin sensitivity were also recorded. Results: After nine months, a significant weight loss of 2.2 kg was observed associated with significant reductions in waist and hip circumference, aortic systolic blood pressure, serum fasting insulin, insulin resistance, and hsCRP levels. Insulin sensitivity was increased, while body fat and visceral fat percentages were marginally reduced (p = 0.058 and p = 0.059). No significant differences were seen in arterial stiffness, fasting plasma glucose and lipid profile. Conclusion: Education on modified lifestyle intervention improved insulin sensitivity and resistance, reduced hsCRP and aortic systolic blood pressure despite the small weight reduction achieved.

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“…The association between changes in IL-6, insulin and HOMA after weight reduction have been found in some studies, [15][16][17]42 whereas Effect of body fat loss on inflammatory markers A Belza et al other studies have not found any relationships. 18,36,38,40 The general absence of correlation between change in hs-CRP and IL-6 and glycemic risk markers of IRS and CVD may be explained by an indirect relationship between the quantity of FM mass and the influence of energy balance, which seems to have a partial influence on concentration levels.…”

Section: Discussionmentioning

confidence: 99%

“…16,28,29,35,36 However, only hs-CRP and IL-6 were Figure 2 Loading plot of factor structure of the pro-inflammatory markers high-sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), fibrinogen, haptoglobin, transferrin and the adipokines leptin and adiponectin. Factor 1 was related to fibrinogen (0.81), CRP (0.63), haptoglobin (0.71), IL-6 (0.64) whereas adiponectin, leptin and transferrin were not.…”

Section: Discussionmentioning

confidence: 99%

Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects

et al. 2009

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Aims:To dissociate the possible differential effects of negative energy balance and reduction in body fat mass (FM) on inflammatory markers: C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), haptoglobin, transferrin and the adipokines leptin and adiponectin. Methods: Thirty-three obese subjects (BMI: 34.0±3.1 kg/m 2 , age: 43.0±10.5 years, mean±s.d., 16 men) participated in a 20-week controlled dietary intervention divided into four periods. Weight reduction was induced by an 8-week low energy diet (3.4 MJ d À1 ) (LED-1) followed by a 4-week weight maintenance program (M-1). Subsequently participants underwent an additional 4-week LED (4.2 MJ d À1 ) (LED-2) followed by a final 4-week weight maintenance diet (M-2). Blood samples and anthropometrics were assessed at baseline and after LED-1, M-1, LED-2 and M-2. Results: Body weight was significantly reduced by 13% (13.7 ± 4.0 kg, Po0.0001) after LED-1. However, a reduction in highsensitive CRP (hs-CRP) by 35% (À1.1 (95% CI: À2.5:0.2) mg l À1 , P ¼ 0.02) only became apparent after LED-2, which produced an additional weight loss of 2.9 kg compared to baseline, and it was maintained after M-2 (À1.0 (À1.4:0.4) mg l À1 , P ¼ 0.02). Also IL-6 was reduced by 21% (À0.6 (À2.4:0.2) ng l À1 , P ¼ 0.02) after M-2. The reductions in hs-CRP and IL-6 were both associated with reduction in FM but not body weight. Haptoglobin, transferrin and leptin were significantly reduced after both LED-1 and LED-2, but increased during weight maintenance. Adiponectin was not significantly changed during the intervention. Conclusions: The results suggest that, whereas haptoglobin and transferrin respond more rapidly and are more susceptible to the acute change in energy balance, a reduction in hs-CRP and IL-6 seems to be achieved by a reduction in FM when a new steady state has been established.

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The effect of a rapid weight loss induced by laparoscopic adjustable gastric banding on arterial stiffness, metabolic and inflammatory parameters in patients with morbid obesity

Cited by 39 publications

References 34 publications

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Improved insulin sensitivity, central systolic pressure and inflammatory indicators achieved with minor weight reduction in overweight and obese subjects given education on lifestyle modification

Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects

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