The effect of a novel crystallised bioactive glass-ceramic powder on dentine hypersensitivity: a long-term clinical study

Abstract

The aim of this comparative clinical study was to evaluate a novel bioactive glass-ceramic (Biosilicate® 1-20 μm particles) to treat dentine hypersensitivity (DH). Volunteers (n = 120 patients/ 230 teeth) received the following treatments: G1-Sensodyne® , G2-SensiKill®, G3-Biosilicate® incorporated in a 1% water-free-gel and G4-Biosilicate® mixed with distilled water at 1:10 ratio. G1 and G3 were applied at home, daily for 30 days; G2 and G4 were applied once a week by a dentist (four applications). A visual analogue scale (VAS) was employed to evaluate pain for each quadrant in one sensitive tooth at baseline, weekly during treatment and during a 6-month follow-up period. Dentine hypersensitivity values (G1/n= 52), (G2/n =62), (G3/n = 59) and (G4/n = 59) were analysed with Kruskal-Wallis/Dunn tests. All the products were efficient in reducing DH after 4 weeks. Among the four materials tested, G4 demonstrated the best clinical performance and provided the fastest treatment to reduce DH pain. Distilled water proved to be an adequate vehicle to disperse Biosilicate®. Low DH scores were maintained during the 6-month follow-up period. The hypothesis that the novel bioactive glass-ceramic may be an efficient treatment for DH was confirmed.

A Pilot Study - Comparison between a Novel Combination of Bioactive Glass with Clodronate and Bioactive Glass Alone as a Treatment for Chronic Periodontitis

“…Based on published data, it is well defined that BAG has several beneficial effects in dental use [8][9][10]. In addition, it also improves the outcome in the given indication, i.e., periodontitis maintenance phase.…”

“…Compared to earlier investigations done with BAG, for example, Biosilicate ® (fully crystallized bioactive glass) in the treatment of hypersensitive teeth [9], the treatment was given twice daily for 30 days. Therefore, it was surprising that with this limited amount of applications, our study gave such good results.…”

“…There are obvious similarities between bone and dentine concerning their metabolism. BAG is potentially useful as a means of stimulating remineralization of the upper layer of the tooth and protecting the tooth against alterations of temperature, pressure, solute concentrations, and local irritation [4,9]. BAG is known to have bacterial growth-inhibiting properties [7,10] and this could provide even more advantages in the treatment of periodontitis, i.e., infection-induced inflammationregulated degradation of tooth-supporting tissues.…”

“…frontal sinus obliteration after severe chronic sinusitis), in orthopedics, and in the treatment of osteomyelitis [5][6][7]. During the last two decades, its use has expanded into dentistry, for instance, for treating cortical bone defects [8] and hypersensitive teeth [4,9]. There are obvious similarities between bone and dentine concerning their metabolism.…”

SEM and AFM characterization of surface of two RMGICs for degradation before and after modification with bioactive glass ceramic

“…The reaction sequence occurs in five stages resulting in hydroxycarbonapatite precipitation on the surface of the material. [5,6] Although most experience with bioactive glasses has been gained in bone medicine research, [7] they have also been used in dentistry, such as treatment of periodontal defects and dentin hypersensitivity. [8,9,10] A previous study reveals that bioactive glasses, especially nanometric particles, induces the odontogenic differentiation and dentin formation of dental pulp cells and may serve as a potential material for pulp repair and dentin regeneration.…”