The Effect of a Non-Androgenic Testisextract on the Estrous Cycle in Rats

McCullagh, D. Roy; Schneider, Ingrid E.

doi:10.1210/endo-27-6-899

Cited by 19 publications

(4 citation statements)

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“…During the period of tubular damage, he found urinary FSH titers increased, whereas urinary LH excretion remained unchanged. Our data provide specific evidence for an increase in plasma Early investigators postulated that a water-soluble factor, "inhibin," of germinal epithelium origin was responsible for regulation of FSH secretion (2)(3)(4)(5). However, this hypothesis has been accepted cautiously since the bioassays used to estimate the urinary FSH and LH excretion were relatively nonspecific.…”

Section: Introductionmentioning

confidence: 69%

“…The precise mechanisms of control and the interrelationships among the various components are poorly understood. Earlier work suggested that damage to the testis primarily affecting the germinal epithelium was associated with increased excretion of FSH (2)(3)(4)(5)(6). Since antitumor drugs, particularly the alkylating agents, are known to induce destruction of germinal tissue (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Thiel¹,

Sherins²,

Myers³

et al. 1972

J. Clin. Invest.

193

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A B S T R A C T The interaction of the testis and gonadotropin secretion was studied in 15 men surviving chemotherapy for lymphoma. Azoospermia and complete destruction of all testicular germinal elements were present in 10 of the 15 men; however, Sertoli cells and Leydig cells were present. In these 10 men plasma follicle-stimulating hormone (FSH) levels were fourfold higher than in normal men of similar age whereas luteinizing hormone (LH) levels were normal. In contrast, both FSH and LH were normal in the remaining five men. Three had a full complement of spermatogenic tissue on biopsy and normal sperm concentrations. The other two men were azoospermic; one demonstrated full spermatogenesis in 30% of his tubules; the other had only a few spermatogonia in all tubules. In those patients with lower levels of gonadotropins pituitary insufficiency was excluded by the demonstration of appropriate responsiveness of FSH and LH to clomiphene administration. Similarly, Leydig cell function was normal since plasma testosterone was within the normal range in 13 of the 15 men and only slightly decreased in two. Thus, following chemotherapy, testicular damage was restricted to the germinal tissue, and this in turn was associated with a selective increase in FSH. The source of the FSH inhibitor is either the Sertoli cell or early germinal elements. However, since FSH levels are only half as high as those reported for castrate men, other testicular factors may modify FSH secretion.

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Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Thiel¹,

Sherins²,

Myers³

et al. 1972

J. Clin. Invest.

193

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“…Assays of androstanediol for antigonadotrophic activity have not been reported. It is nevertheless interesting that evidence for the testicular production of an inhibitor of FSH secretion other than testosterone continues to accumulate (13,14).…”

Section: Discussionmentioning

confidence: 99%

Metabolism of Progesterone by Rat Testicular Homogenates. II. Changes with Age

1966

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Whole homogenates of testes from rats of different sizes have been incubated with progesterone-4-14 C and labeled products have been isolated and assayed for radioactivity. A marked change in the pattern of metabolites takes place when the rats are 200-300 g in weight (7-9 weeks). With testes from 150-200 g animals testosterone is formed in appreciable yields but to a great extent is further metabolized, principally to 5a-androstane-3a,17/?-diol. The ring A reductase activity responsible for this transformation appears to decrease during an early phase of rapid sexual maturation. It is suggested that this change in testicular enzymatic activities may play a role, and that 5«-androstane-3a,17/3-diol may serve some special function in the process of sexual maturation. {Endocrinology 78:1041,1966)

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“…The present results are also consistent with those of Johnsen (15,16), who studied a large series of patients with a variety of primary testicular disturbances and observed a highly significant negative correlation between spermatogenesis and total gonadotropin levels as determined by bioassay. On the basis of his testicular biopsy findings, Johnson suggested that "inhibin"-a substance of unknown chemical structure secreted by the seminiferous epithelium which circulates in plasma and inhibits FSH secretion (17)(18)(19)-might be formed at the end stage of spermatogenesis.…”

Section: Fshmentioning

confidence: 99%

Relationship between Spermatogenesis and Serum Gonadotropin Levels in Azoospermia and Oligospermia

Franchimont

Millet

Vendrely

et al. 1972

The Journal of Clinical Endocrinology & Metabolism

204

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Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, the sperm count and the histologic appearance of the testis were studied in 56 patients with azoospermia or oligospermia.FSH is elevated in those cases of azoospermia where gametogenesis is arrested prior to spermatid differentiation. Serum FSH is normal, however, in most patients in whom spermatids and spermatozoa are detectable on testicular biopsy. There is no relationship between the sperm count and the concentration of serum FSH.No correlation exists between serum LH and either the sperm count or the stage of spermatogenesis as evaluated on testicular biopsy. (/ Clin Endocrinol Metab 34: 1003, 1972

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The Effect of a Non-Androgenic Testisextract on the Estrous Cycle in Rats

Cited by 19 publications

References 0 publications

Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Metabolism of Progesterone by Rat Testicular Homogenates. II. Changes with Age

Relationship between Spermatogenesis and Serum Gonadotropin Levels in Azoospermia and Oligospermia

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