The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord

Li, Xiaowei; Zhang, Chi; Haggerty, Agnes E.; Yan, Jerry; Lan, Michael J.; Seu, Michelle; Yang, Mingyu; Marlow, Megan M.; Maldonado-Lasunción, Inés; Cho, Brian; Zhou, Zhengbing; Chen, Long; Martin, Russell; Nitobe, Yohshiro; Yamane, Kyoko; You, Hua; Reddy, Sashank K.; Quan, Da Ping; Oudega, Martin; Mao, Hai Quan

doi:10.1016/j.biomaterials.2020.119978

Cited by 106 publications

(90 citation statements)

References 61 publications

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“…Li and colleagues developed an injectable nanofiber-hydrogel composite and implanted it in an adult rat model of spinal cord contusion. After 28 days, they found that the treated rats had a higher M2/M1 macrophage ratio, blood vessel density, neuron presence, and axon density, suggesting the fundamental role of this biomaterial in the treatment of SCI [137]. Another interesting approach for nerve regeneration is to create nerve guidance conduits.…”

Section: Nanofibersmentioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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Neurodegenerative disorders (i.e., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. Despite many studies having focused on their etiopathology, the exact cause of these diseases is still unknown and until now, there are only symptomatic treatments. Biomaterials have become important not only for the study of disease pathogenesis, but also for their application in regenerative medicine. The great advantages provided by biomaterials are their ability to mimic the environment of the extracellular matrix and to allow the growth of different types of cells. Biomaterials can be used as supporting material for cell proliferation to be transplanted and as vectors to deliver many active molecules for the treatments of neurodegenerative disorders. In this review, we aim to report the potentiality of biomaterials (i.e., hydrogels, nanoparticles, self-assembling peptides, nanofibers and carbon-based nanomaterials) by analyzing their use in the regeneration of neural and glial cells their role in axon outgrowth. Although further studies are needed for their use in humans, the promising results obtained by several groups leads us to suppose that biomaterials represent a potential therapeutic approach for the treatments of neurodegenerative disorders.

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Section: Nanofibersmentioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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“…Synthetic materials can be modified to have tunable mechanical properties [ 23 ], but the properties that promote desirable outcomes still need to be identified. Finally, hydrogel microstructures need to be considered as they have dramatic effects on cell behaviors and also can affect tissue regeneration [ 33 , 34 ]. Finally, injectable hydrogel is considered superior to three-dimensional (3D) hydrogel scaffolds that require incisions for their placement in the recipient leg [ 24 ].…”

Section: Bioengineering Approaches For the Treatment Of Padmentioning

confidence: 99%

“…It is worth noting that current studies have overlooked the mechanistic role of the inflammatory activation in PAD progression. Hydrogels able to induce pro-regenerative and pro-angiogenic monocyte polarization may have clear value toward clinical applications [ 33 , 34 ]. Third, rapid in situ formation is desirable to facilitate delivery using small gauge needles that will allow for injection of the agent while it is still in liquid form with minimal injury of the recipient tissue.…”

Section: Outlook and Challengesmentioning

confidence: 99%

Bioengineering strategies for the treatment of peripheral arterial disease

Kitzerow

Nie

et al. 2021

Bioactive Materials

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Peripheral arterial disease (PAD) is a progressive atherosclerotic disorder characterized by narrowing and occlusion of arteries supplying the lower extremities. Approximately 200 million people worldwide are affected by PAD. The current standard of operative care is open or endovascular revascularization in which blood flow restoration is the goal. However, many patients are not appropriate candidates for these treatments and are subject to continuous ischemia of their lower limbs. Current research in the therapy of PAD involves developing modalities that induce angiogenesis, but the results of simple cell transplantation or growth factor delivery have been found to be relatively poor mainly due to difficulties in stem cell retention and survival and rapid diffusion and enzymolysis of growth factors following injection of these agents in the affected tissues. Biomaterials, including hydrogels, have the capability to protect stem cells during injection and to support cell survival. Hydrogels can also provide a sustained release of growth factors at the injection site. This review will focus on biomaterial systems currently being investigated as carriers for cell and growth factor delivery, and will also discuss biomaterials as a potential stand-alone method for the treatment of PAD. Finally, the challenges of development and use of biomaterials systems for PAD treatment will be reviewed.

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“…This heparin-modified ECM exhibits beneficial effects on reducing long-term thromboresistance and targeting VEGF to facilitate the adhesion and growth of endothelial cells (28). Another representative study by Li et al identified nanofiber-hydrogel modification for repairing ScI (29). They engineered an injectable nanofiber-hydrogel composite (NHC) by covalently conjugating hyaluronic acid (HA) hydrogel with electrospun polycaprolactone (PCL) fibers.…”

Section: Ecm-g Characterizationmentioning

confidence: 99%

Extracellular matrix grafts: From preparation to application (Review)

Jiang

Han

et al. 2020

Int J Mol Med

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Recently, the increasing emergency of traffic accidents and the unsatisfactory outcome of surgical intervention are driving research to seek a novel technology to repair traumatic soft tissue injury. From this perspective, decellularized matrix grafts (ECM-G) including natural ECM materials, and their prepared hydrogels and bioscaffolds, have emerged as possible alternatives for tissue engineering and regenerative medicine. Over the past decades, several physical and chemical decellularization methods have been used extensively to deal with different tissues/organs in an attempt to carefully remove cellular antigens while maintaining the non-immunogenic ECM components. It is anticipated that when the decellularized biomaterials are seeded with cells in vitro or incorporated into irregularly shaped defects in vivo , they can provide the appropriate biomechanical and biochemical conditions for directing cell behavior and tissue remodeling. The aim of this review is to first summarize the characteristics of ECM-G and describe their major decellularization methods from different sources, followed by analysis of how the bioactive factors and undesired residual cellular compositions influence the biologic function and host tissue response following implantation. Lastly, we also provide an overview of the in vivo application of ECM-G in facilitating tissue repair and remodeling.

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The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord

Cited by 106 publications

References 61 publications

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bioengineering strategies for the treatment of peripheral arterial disease

Extracellular matrix grafts: From preparation to application (Review)

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