The effect of a macrolid antibiotic on the control of mycoplasmas and production efficiency in broilers

Abstract

Various antibiotics are used in Albania for controlling of Mycoplasmas. The main groups of antibiotics with broad spectrum are the tetracycline group (Oxitetracycline, Chlortetracycline, Doxicycline), kinolone group (Enrofloxacine, Norfloxacine, Flumequine) and macrolide group (Tylosine, Erithromycine and Rovomycine). Tilmicosin is a macrolide antibiotic which has not been used in Albania before. Tilmicosin is not being used in human medicine and it acts very well against Mycoplasmas with good results in the performance of birds. Considering that Tilmicosin is a specific antibiotic against some bacteria, particularly against Mycoplasmas, its use presents a great treatment possibility and it?s the right time to introduce it also in Albania. The aim of the study was to investigate the effect of the Tilmicosin use on mycoplasmas control in broilers and the impact on the production efficiency. Both, control and experimental flock were Mg and Ms positive (ELISA?s test and Cultural control). The experimental results showed that the flock treated with Tilmicosin had a better control on mycoplasmas and better technical and economical results than the control flock. The antibiotic use resulted in a lower mortality rate in broilers compared to the untreated ones. Based on the results of the study some practical recommendations on the use of antibiotic Tilmicosin are also given.

Multi-epitope-Based Vaccine Designed by Targeting Cytoadherence Proteins of Mycoplasma gallisepticum

“…Avian mycoplasmosis has caused a substantial economic loss globally by significantly reducing egg production, meat quality, and hatchability rate. 12 Control of M. gallisepticum by antibiotics is practiced in most poultry farms, and the widely used antibiotics are tetracyclines, macrolides (tylosin and tilmicosin), fluoroquinolones (enrofloxacin and difloxacin), and pleuromutilins (tiamulin). 13,14 The widespread use of antibiotics has led to the rise and spread of resistant bacteria over time.…”

A Computational Reverse Vaccinology Approach for the Design and Development of Multi-Epitopic Vaccine Against Avian Pathogen Mycoplasma gallisepticum

“…One such example is quinolone resistance in M. gallisepticum which happens to be frequent, dampening the treatment and control methods (17). The antibiotics can reduce the population of M. gallisepticum in the respiratory tract, thereby reducing the risk of spread to neighboring flocks (18). Currently available vaccines for M. gallisepticum infections are killed bacterins, live attenuated strains, and recombinant protein; of these, the commercially approved live attenuated vaccine includes 6/85 strain, ts-11, and F strains which are widely used in layers and commercial flocks.…”

“…One such example is quinolone resistance in M. gallisepticum which happens to be frequent, dampening the treatment and control methods ( 17 ). The antibiotics can reduce the population of M. gallisepticum in the respiratory tract, thereby reducing the risk of spread to neighboring flocks ( 18 ). Currently available vaccines for M .…”

Impact of dietary methionine on respiratory tissue integrity and humoral immunity of broilers challenged withMycoplasma gallisepticumand treated with PulmotilAC®

“…It is worth noting that Pulmotil AC® treatment (Groups 6 and 7) cleared MG infection in challenged groups (5-8); which was reflected by the subsequent absence of antibody response to MG proteins, as revealed by ELISA, in comparison to those untreated with tilmicosin (Groups 5 and 8). These results offer an additional proof of the superiority of tilmicosin in treating MG infection in poultry (Charleston et al, 1998;Abd El-Ghany, 2009;Mavromati, 2011)…”