“…18 Both lipoperoxides and monounsaturated fatty acid (MUFA) are capable of inducing alteration in keratinocyte proliferation and differentiation, whereas peroxides are capable of inducing production of pro-inflammatory cytokines and activation of peroxisome proliferator-activated receptors (PPAR). 13,18 The biological function of sebocytes is further regulated by several factors including ligands of receptors expressed in sebocytes, such as androgens and estrogens, PPAR ligands and neuropeptides (NP), liver-X receptor ligands (LXR), histamines, retinoids and vitamin D. The ligand-receptor complexes activate pathways involving cell proliferation, differentiation, lipogenesis, hormone metabolism and cytokine and chemokine release 19 ( Fig. 2).…”