The effect of a lipid-lowering diet on plasma lipids and lipoproteins in mildly hypercholesterolaemic subjects: a potential role for occasional treats

Samman, Samir; Lai, Nicole T; Sullivan, David

doi:10.1016/s0955-2863(00)00072-3

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Blood cholesterol concentration of consumers who were provided with 280 g or 46 g chocolate per day did not increase during the experiments (Kris-Etherton, Derr, Mustad, Seligson, & Pearson, 1994). Samman, Lai, and Sullivan (2000) also stated that a chocolate bar of 25 g could be safely included in a cholesterol-lowering diet of consumers.…”

Section: Cholesterol Contents Of the Chocolate Samplesmentioning

confidence: 99%

Cholesterol content and fatty acid profile of chocolates mostly consumed in Turkey Contenido de colesterol y perfil de ácidos grasos de los chocolates más consumidos en Turquía

Ergönül

Seçkin

2010

CyTA - Journal of Food

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Section: Cholesterol Contents Of the Chocolate Samplesmentioning

confidence: 99%

Cholesterol content and fatty acid profile of chocolates mostly consumed in Turkey Contenido de colesterol y perfil de ácidos grasos de los chocolates más consumidos en Turquía

Ergönül

Seçkin

2010

CyTA - Journal of Food

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“…However, while 60% of the fat in cocoa butter exists as saturated stearic and palmitic acid (Otton et al 1998, Steinberg et al 2003, studies to date have typically shown neutral, or positive effects of cocoa consumption on plasma lipid markers (Kris-Etherton and Mustad 1994, Saamman et al 2000, Wan et al 2001. A recent meta-analysis of 60 studies concluded that palmitic acid had little effect on the ratio of total to HDL cholesterol, while stearic acid tended to reduce this ratio (Mensink et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Flavanols and Platelet Reactivity

Pearson

Holt²,

Rein³

et al. 2000

Journal of Immunology Research

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Platelet activity and platelet-endothelial cell interactions are important in the acute development of thrombosis, as well as in the pathogenesis of cardiovascular disease. An increasing number of foods have been reported to have platelet-inhibitory actions, and research with a number of flavanol-rich foods, including, grape juice, cocoa and chocolate, suggests that these foods may provide some protection against thrombosis. In the present report, we review a series of in vivo studies on the effects of flavanol-rich cocoa and chocolate on platelet activation and platelet-dependent primary hemostasis. Consumption of flavanol-rich cocoa inhibited several measures of platelet activity including, epinephrine- and ADP-induced glycoprotein (GP) IIb/IIIa and P-Selectin expression, platelet microparticle formation, and epinephrine-collagen and ADP-collagen induced primary hemostasis. The epinephrine-induced inhibitory effects on GP IIb/IIIa and primary hemostasis were similar to, though less robust than those associated with the use of low dose (81 mg) aspirin. These data, coupled with information from other studies, support the concept that flavanols present in cocoa and chocolate can modulate platelet function through a multitude of pathways.

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Dietary Flavanols and Platelet Reactivity

Holt

Actis‐Goretta

Momma

et al. 2006

Journal of Cardiovascular Pharmacology

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Epidemiology studies suggest that the consumption of diets rich in flavonoids is associated with reduced risk of cardiovascular disease. Plant-derived foods and beverages, such as red wine, tea, grape and grape juice, cocoa and chocolate, can be rich in 1 particular class of flavonoid, the flavan-3-ols. There is now an increasing body of research that suggests that consuming flavanol-rich foods can positively affect hemostasis, through mechanisms that either directly affect platelet function or increase certain endothelium-derived factors that maintain platelet acquiescence or increase fibrinolysis. In this paper, we will review a series of in vivo studies on the effects of flavanol-rich cocoa and chocolate on platelet activation and platelet-dependent hemostasis. In addition, we will briefly review the body of literature with regard to other flavanol-rich foods and beverages, and possible mechanisms of action.

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The effect of a lipid-lowering diet on plasma lipids and lipoproteins in mildly hypercholesterolaemic subjects: a potential role for occasional treats

Cited by 3 publications

References 16 publications

Cholesterol content and fatty acid profile of chocolates mostly consumed in Turkey Contenido de colesterol y perfil de ácidos grasos de los chocolates más consumidos en Turquía

Cholesterol content and fatty acid profile of chocolates mostly consumed in Turkey Contenido de colesterol y perfil de ácidos grasos de los chocolates más consumidos en Turquía

Flavanols and Platelet Reactivity

Dietary Flavanols and Platelet Reactivity

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