The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease

Abstract

The primary objective of the study was to evaluate the effect of a hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), on biomarkers in adults with nonalcoholic fatty liver disease (NAFLD). A 90-day randomized double-blind placebo-controlled trial examined the effect of RBAC on complete blood count, liver enzymes, lipids, oxidative stress markers, cytokines, and growth factors. Twenty-three adults with NAFLD were enrolled and randomly assigned to one of the two study conditions (n = 12 RBAC and n = 11 placebo) and consumed 1 gram/day of either compound for 90 days. Subjects were assessed at baseline and 45 and 90 days. No adverse effects were reported. Alkaline phosphatase significantly decreased (−3.1%; SD = 19.9; F[1,19] = 5.1, p = 0.03) in the RBAC group compared to placebo. Percent monocytes (17.9%; SD = 18.3; F[1,19] = 5.9, p = 0.02) and percent eosinophils (30.6%; SD = 30.5; F[1,19] = 12.3, p < 0.01) increased in the RBAC group. IFN-γ (156%; SD = 131.8; F[1,19] = 4.2, p = 0.06) and IL-18 (29.1%; SD = 64; F[1,19] = 5.3, p = 0.03) increased in the RBAC group compared to placebo. Other improvements were noted for platelets, neutrophils, neutrophil-lymphocyte ratio, γ-glutamyl transferase, and 4-hydroxynonenal. RBAC had beneficial effects on several biomarkers that add to the known immunomodulatory activities of RBAC, which may be promising for people with NAFLD.

Association between consumption of edible seaweeds and newly diagnosed non‐alcohol fatty liver disease: The TCLSIH Cohort Study

“…Evidence suggests that some components of seaweeds‐namely, fibre, polyphenol and carotenoids‐may protect against NAFLD 43,44 . Firstly, dietary fibre is the largest component of the seaweed biomass 45 .…”

Efficacy of Brazilian Propolis Supplementation for Japanese Lactating Women for Atopic Sensitization and Nonspecific Symptoms in Their Offspring: A Randomized, Double-Blind, Placebo-Controlled Trial

“…If its efficacy is confirmed, it would suggest a significant health benefit that could be accessed broadly and easily. A group at the University of Miami Miller School of Medicine suggested the effect of a hydrolyzed polysaccharide supplement from rice bran on immunomodulatory biomarkers in adults with nonalcoholic fatty liver disease [24, 25]. A Korean research group suggested that acute grape seed extract can be an effective way to decrease cellular membrane damage after excessive exercise [26].…”

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme—A Narrative Review

“…Decreases in both neutrophils and neutrophil-to-lymphocyte ratio in RBAC group compared to placebo were also observed, even though not statistically significant, may be clinically relevant. No adverse events caused by RBAC was reported in this study [ 82 ]. Overall, the evidence on the beneficial effects of RBAC for managing NAFLD is promising.…”

“…RBAC supplementation also benefits patients with nonalcoholic fatty liver disease (NAFLD). In a 90-day double-blind, placebo RCT [ 82 ], 23 NAFLD patients were randomly assigned to consume 1 g/day of either RBAC or placebo. Serum biomarkers were assessed at baseline, 45, and 90 days.…”

“…Alkaline phosphatase, a hallmark of liver damage, significantly decreased ( p = 0.03) in the RBAC group compared to placebo. Significant increases in the eosinophils ( p = 0.02), monocytes ( p < 0.001), and IL-18 ( p = 0.03) in the RBAC group compared to placebo were also detected at the 90-day follow-up, suggestive of the immunomodulatory effects of RBAC [ 82 ]. Decreases in both neutrophils and neutrophil-to-lymphocyte ratio in RBAC group compared to placebo were also observed, even though not statistically significant, may be clinically relevant.…”