The Effect of a combination of 12% spirulina and 20% chitosan on macrophage, PMN, and lymphocyte cell expressions in post extraction wound

Hendrijantini, Nike; Rostiny, Rostiny; Kuntjoro, Mefina; Young, Kelvin; Shafira, Bunga; Pratiwi, Yunita Satya

doi:10.20473/j.djmkg.v50.i2.p106-110

Cited by 1 publication

(1 citation statement)

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“…17,18 Medicinal herbs are often used in the health sector, which is proven to be efficacious and has low side effects compared to synthetic drugs. 19 One of the medicinal herbs used is ramania (Bouea macrophylla Griff). Ramania is a typical plant of South Kalimantan that can be used as herbal medicine for wound healing because it has secondary metabolites such as flavonoids, steroids, phenols and terpenoids.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ramania Leaves Extract Gel (Bouea macrophylla Griff) on the Number of Osteoblast (in vivo Study of Post Extraction in Wistar Rats (Rattus norvegicus))

Taufiqurrahman,

Gupita,

Oktiani

et al. 2024

Pharmacogn J.

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Ramania leaves extract contains secondary metabolite compounds such as flavonoids, steroids, phenols and terpenoids which can be used as an alternative medicine for socket wound healing. Flavonoids have anti-inflammatory and antioxidant properties that can accelerate wound healing and can stimulate the formation of osteoblasts. Analyzing the differences in the number of osteoblasts in the negative control group, positive control given aloe vera gel 15% and ramania leaf extract gel 15% on day 5, 7 and 14. This study used true experimental design with posttest-only control design, using 27 rats divide into 3 groups. The experimental animals were sacrificed on days 5, 7 and 14 for histopathological observations. Two-Way ANOVA test results obtained p value = 0.013 <0.05, which indicates that there is a significant difference between the use of 15% ramania leaf extract gel 15% and the number of osteoblasts on days 5, 7 and 14. Bonferroni's Post Hoc test showed a difference. The number of osteoblasts was significant among the negative control group with ramania leaf extract gel 15%. Ramania leaf extract gel 15% was proven to be able to increase the number of osteoblasts and has the potential as an alternative medicine for socket healing after tooth extraction.

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Section: Introductionmentioning

confidence: 99%