The Effect of a Change of Oral Environment Accordance with an Experimental Palatal Plate and Occlusal Interference on Electroencephalograms.

Mushimoto, Eiko; Tanaka, Hisatoshi; Ichikawa, Dai

doi:10.2186/jjps.45.295

Cited by 3 publications

(1 citation statement)

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“…Further, experimental occlusal interference in humans induces changes in brain waves corresponding to feelings of discomfort 3,4) . In rats, the application of a bite-raising device increases catecholamine secretion in the central nervous system (including the hypothalamus), corticosterone (CO) concentrations in the blood, and glucocorticoids (GC) in the urine [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Malocclusion induces chronic stress

Iinuma¹,

Ichihashi²,

Hioki³

et al. 2008

Okajimas Folia Anat. Jpn.

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Summary:We examined the effect of occlusal disharmony in senescence-accelerated (SAMP8) mice on plasma corticosterone levels, spatial learning in the water maze, fos induction, hippocampal neuron number, expression of glucocorticoid receptors (GR) and glucocorticoid receptor messenger ribonucleic acid (GRmRNA) in hippocampus and inhibitor of glucocorticoid (metyrapone).Bite-raised aged mice had significantly greater plasma corticosterone levels than age-matched control mice as well as impaired spatial memory and decreased Fos induction and a number of neurons in hippocampus. GR and GRmRNA expressions were significantly decreased in aged bite-raised mice compared with age-matched control mice. Pretreatment with metyrapone inhibited not only the bite-raised induced increase in plasma corticosterone levels, but also the reduction in the number of hippocampal neurons and impaired spatial learning.These datas suggest that the bite-raised condition may enhance the aging process in hippocampus, thereby leading to impairment of spatial memory by stress.

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