The effect of a 12-week resistance training intervention on leukocyte telomere length

Nickels, Matt; Mastana, Sarabjit S.; David, Hunter; Denniff, Matthew; Akam, Elizabeth Claire

doi:10.1016/j.heliyon.2020.e04151

Cited by 14 publications

(8 citation statements)

References 35 publications

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“…Another study conducted on hypertension patients who participated in Transcendental Meditation for 16 weeks showed a non-significant increase in the TERT gene expression after the intervention program ( 41 ), however, in our study, we did not observe this change for the TERT gene at week 12 in YBLI but it gives the impression that 12 or more weeks of yoga intervention might change the TERT expression. Similar to our study SC group (physical exercise+ diet), the 12-weeks resistance training program did influence the TERT expression in sedentary middle-aged adults ( 64 ). Cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) play a major role in the body's inflammatory response.…”

Section: Discussionsupporting

confidence: 80%

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Sharma

Yadav²,

Khadgawat³

et al. 2022

Front. Med.

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IntroductionObesity is one of the major global problems in today's world, both in children, and the adult age group. Current evidence suggests obesity alters the expression of various genes related to oxidative stress, inflammation, and aging. In recent times complementary therapy like yoga-based lifestyle intervention (YBLI) is used as an adjunct therapy to modern medicine. This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care (SC) on the expression of genes related to oxidative stress, inflammation, and aging in obese adults.MethodsThis was a two-arm parallel randomized control trial implemented at Integral Health Clinic (IHC), an outpatient facility that regularly conducted YBLI programs for the prevention of lifestyle diseases like obesity and diabetes in the Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi. Blood samples at baseline and weeks 2,4, and 12 were collected from 72 adults (male n = 21; female n = 51) of age 20–45 years with a body–mass index (BMI) of 25–35 kg/m2 who were randomized to receive either a 12-week SC (n = 36) or YBLI (n = 36). SC included recommendations for the management of obesity as per Indian guidelines including a low-calorie individualized diet and physical activity. Asana (physical postures), pranayama (breathing exercises), and meditation were all part of the YBLI. Primary outcomes were relative fold change in the expression of genes associated with oxidative stress [Nuclear factor-kappa B (NF-Kappa B)], inflammation [Tumor necrosis factor-α (TNFα), interleukin-6 (IL-6)], and aging [human telomerase reverse transcriptase (TERT)] in peripheral blood mononuclear cells between the two groups at week-12.ResultsThere were no significant changes in fold change of TERT, IL-6, and NF-kappa B between the groups at week 12. The relative fold change of TERT was significantly greater in the YBLI group (p = <0.0001) vs the SC group at 2 weeks. The relative fold change of TNF α was significantly lower at week 12 in YBLI though the change was not continuous and reliable. Within both groups, TERT expression was significantly increased at week 2 though the change was greater in the YBLI group (p < 0.0001). TNF α gene expression was significantly lower at weeks 2 and 4, compared to baseline level, in the SC group but it increased at week 12.ConclusionThe results while did not confirm our hypothesis, are important to share with the scientific society, to be able to improve prospective study designs and find optimal time/intervention/biological marker settings for this highly important scientific field. The results are suggestive of a positive impact of YBLI and SC on the fold change of aging-related TERT gene in obesity, though the benefit was not evident till week 12. However, the results should be evaluated with caution and in light of other published studies. To better understand the positive effects of YBLI on oxidative stress, inflammation, and aging-related gene expression in obesity, larger studies are recommended.

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Section: Discussionsupporting

confidence: 80%

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Sharma

Yadav²,

Khadgawat³

et al. 2022

Front. Med.

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“…To date, we have found only one article that assesses the impact of a resistance exercise program 12 months after the end of the program. Nickels et al [ 46 ] conclude that those subjects who returned to a sedentary lifestyle during the 12 months after the intervention showed a significant reduction in telomere length. However, those subjects who continued to exercise after the intervention did not show reduced telomere length.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women

et al. 2021

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Background: Physical exercise is an effective measure for preventing the onset of cognitive decline and has a direct influence on the aging process. The purpose of this study was to assess the effect of a 6-month physical exercise program on cognition and telomere length in adults over 65 years of age. Method: Seventy-four healthy women were separated into two groups: 41 were included in the intervention group (IG) (72.70 ± 4.127 years and 8.18 ± 1.551 years of education) and 33 in the control group (CG) (71.21 ± 4.127 years and 8.42 ± 2.562). The participants included within the IG carried out three sessions of physical exercise per week for six months. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), the Stroop test and the Trail Making Test (TMT). Saliva samples were taken and analyzed and relative telomere length was calculated. Those conducting the analysis were blind to the group to which the participants had been assigned. Results: An improvement was observed in global cognitive function, in both attentional and executive functions, in the group of adults doing physical exercise as compared to the control group. Six months after the physical exercise program had finished, relative telomere length was found to have increased in the participants in the intervention group. Conclusion: Physical exercise programs can lead to an improvement in both cognitive functions and telomere length.

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“…Short-term aerobic exercise training did not affect telomere length in obese women with polycystic ovary symptom [ 37 ]. In a study examining the effect of 12-week resistance training on telomere length, it was noted that although no change was observed in telomere length after the intervention, there were improvements in molecular parameters related to telomere integrity [ 38 ].…”

Section: Effects Of Physical Activity On Telomere Lengthmentioning

confidence: 99%

Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length

Gürel,

Pak,

Tek

2024

Curr Nutr Rep

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Purpose of Review The number and proportion of individuals aged 60 and over are increasing globally. The increase in the elderly population has important social and economic effects. Telomere length is an important marker for healthy aging. Here, we review the relevance between telomere length and energy balance by determining the effects of physical activity, nutrients, dietary patterns, and foods on healthy aging and telomere length with related studies. Recent Findings Evidence emphasizes the importance of telomere length and integrity for healthy aging. It also focuses on the importance of potential interventions such as physical activity and a healthy diet to improve this process. Summary We suggest that ensuring energy balance with regular physical activity and healthy diets can contribute to the aging process by protecting telomere length. In addition, different methods in studies, short and inconsistent durations, different types of exercise, different diet patterns, and non-standard foods have led to conflicting results. More studies are needed to elucidate molecular-based mechanisms.

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The effect of a 12-week resistance training intervention on leukocyte telomere length

Cited by 14 publications

References 35 publications

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women

Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length

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