The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls

Paaver, Marika; Kurrikoff, Triin; Nordquist, Niklas; Oreland, Lars; Harro, Jaanus

doi:10.1016/j.pnpbp.2008.03.021

Cited by 59 publications

(45 citation statements)

References 45 publications

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“…When the sample was split by gender, the interaction between genetic risk and spanking failed to reach statistical significance for females. This finding is not surprising, given the results produced by Paaver et al [2008]. These researchers detected a significant interaction between genetic factors and family risk in the prediction of female impulsivity.…”

Section: Discussionmentioning

confidence: 79%

“…Finally, Paaver et al [2008] analyzed approximately 222 boys and 261 girls drawn from the European Youth Heart Study. Paaver et al [2008] were interested in whether certain variants of the 5-HTTLPR serotonin transporter gene conditioned the influence of adverse family environments on levels of impulsivity.…”

Section: Gene-environment Interaction and Corporal Punishmentmentioning

confidence: 99%

“…Paaver et al [2008] were interested in whether certain variants of the 5-HTTLPR serotonin transporter gene conditioned the influence of adverse family environments on levels of impulsivity. The results of the study provided evidence of a significant interaction between the short allele of the gene and family adversity in the prediction of impulsive behaviors.…”

Section: Gene-environment Interaction and Corporal Punishmentmentioning

confidence: 99%

See 2 more Smart Citations

Physical punishment and childhood aggression: the role of gender and gene–environment interplay

Boutwell

Franklin

Barnes

et al. 2011

Aggressive Behavior

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A large body of research has linked spanking with a range of adverse outcomes in children, including aggression, psychopathology, and criminal involvement. Despite evidence concerning the association of spanking with antisocial behavior, not all children who are spanked develop antisocial traits. Given the heterogeneous effects of spanking on behavior, it is possible that a third variable may condition the influence of corporal punishment on child development. We test this possibility using data drawn from a nationally representative dataset of twin siblings. Our findings suggest that genetic risk factors condition the effects of spanking on antisocial behavior. Moreover, our results provide evidence that the interaction between genetic risk factors and corporal punishment may be particularly salient for males.

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Section: Discussionmentioning

confidence: 79%

Section: Gene-environment Interaction and Corporal Punishmentmentioning

confidence: 99%

Section: Gene-environment Interaction and Corporal Punishmentmentioning

confidence: 99%

See 1 more Smart Citation

Physical punishment and childhood aggression: the role of gender and gene–environment interplay

Boutwell

Franklin

Barnes

et al. 2011

Aggressive Behavior

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“…Paaver et al (2007) studied the effects of 5-HTTLPR polymorphism among adolescents who participated in the Estonian Children Personality Behavior and Health Study and concluded that participants with the S allele reported higher impulsivity and error rates measured by visual comparison task (VCT) assessments. In another study of the same population, Paaver et al (2008) also showed that participants with the SS genotype were more susceptible to stressful familial and environmental triggers and showed increased disinhibition and impulsivity. Table 2 shows the summary of studies that showed associations between 5-HTTLPR polymorphism and sexual risk behaviors.…”

Section: -Httlpr Polymorphism and Sexual Risk Behaviorsmentioning

confidence: 85%

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

et al. 2015

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Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect.

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“…The preceding lends credence to the idea that when gene-environment effects implicating 5-HT polymorphisms and stress are observed in humans, they also implicate stress-induced activation of genetically primed, serotonergic susceptibilities. Although contradictions and controversies exist (Risch et al 2009), several reports have indicated that childhood maltreatment (and other life stressors) confers disproportionate vulnerability to depression (Caspi et al 2003), behavioral disinhibition (Paaver et al 2008), and impulsivity (Wagner et al 2009) in human carriers of low-function alleles of 5HTTLPR. Consistent with such observations, some of our recent findings have linked severe stressors to heightened expression of psychopathological traits in eating-disordered women who carry low-function 5HTTLPR alleles.…”

Section: Gene-environment Interactions and Personality-trait Expressionsmentioning

confidence: 99%

Neural Circuits, Neurotransmitters, and Behavior

Steiger

Bruce

Groleau

2010

Behavioral Neurobiology of Eating Disorders

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In bulimia nervosa (BN), and in related binge-purge syndromes, factors affecting central serotonin (5-hydroxytryptamine, 5-HT) function appear to contribute not only to appetitive dysregulation but also to temperamental and personality manifestations. Drawing upon findings from neurobiological, molecular-genetic, and brain-imaging studies, we present an integrative model of the role of 5-HT function in bulimic syndromes. At the core of our model is a consideration of the ways in which diverse hereditary and environmental influences impact the action of the 5-HT system. We believe that our model helps account for heterogeneous traits seen in the bulimic population, for disproportionate representation of individuals displaying pathological personality traits and exposure to severe environmental stressors, and for interindividual variations as to treatment response.

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The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls

Cited by 59 publications

References 45 publications

Physical punishment and childhood aggression: the role of gender and gene–environment interplay

Physical punishment and childhood aggression: the role of gender and gene–environment interplay

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

Neural Circuits, Neurotransmitters, and Behavior

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