The effect of 3‐nitro‐4‐hydroxyphenylarsonic acid (3‐nitro‐hoechst) on egg production and food conversion of laying hens and residue analyses of muscle, organs and eggs

Stute, Karl; Vogt, Hermann

doi:10.1080/00071666808415701

Cited by 1 publication

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References 13 publications

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“…The mortality reached 13É3% as dietary roxarsone increased to 1000 mg kg~1, whereas the mortality reached 80% at the level of 2000 mg kg~1 of inclusion. Stute and Vogt (1968) examined the inÑuence of roxarsone on egg production and food conversion of laying hens and residue of muscles, organs and egg. Their results did not indicate residues in eggs above the FDA tolerance of 500 mg kg~1.…”

Section: Introductionmentioning

confidence: 99%

Effects of Roxarsone on Performance, Toxicity, Tissue Accumulation and Residue of Eggs and Excreta in Laying Hens

Chiou

Chen

1997

J. Sci. Food Agric.

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In this study, we examined the effects of a high dosage of roxarsone in the diet on the performance, liver function, and its residue in liver, eggs and excreta of laying hens. Seventy‐five 32‐week‐old layers were selected and randomly allocated into five dietary treatments with three replications for each treatment. Feeding periods were 4 weeks with an additional week for withdrawal. The experimental diets included 0, 11, 22, 44 or 88 mg kg‐1 arsenic from roxarsone, respectively. Dietary arsenic above 44 mg kg‐1 significantly decreased the egg production and feed intake of the layer (P < 0·05). Layers ceased to produce eggs after two weeks of feeding the 88 mg kg‐1 arsenic supplement diet. Where the enzyme activities in the serum, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) significantly increased. Also, the liver weight did not only significantly decrease (P < 0·05), but was also damaged on histological examination. Moreover, arsenic residues in the liver, eggs and the excreta significantly increased as dietary arsenic level was increased (P < 0·05). The serum enzyme activities of AST, LDH, CK returns to normal after a week of the drug withdrawal. Arsenic residues in liver, egg and excreta also significantly declined in the withdrawal period (P < 0·05). Furthermore, the hepatic cells were vacuolised from layers treated with 88 mg kg‐1 of arsenic. © 1997 SCI.

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Section: Introductionmentioning

confidence: 99%