The Effect of 3-Hydroxypyridine and Succinic Acid Derivatives on Hippocampal Monoamine Oxidase Activity in Rats with Alloxan-Induced Diabetes

Волчегорский, И. А.; Синицкий, А. И.; Miroshnichenko, I. Yu.; Рассохина, Л. М.

doi:10.1134/s0022093020010020

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…In particular, it is known that succinic acid can penetrate the BBB, and exogenous treatment with succinic acid exerts ameliorative effects on mitochondrial dysfunction and neurodegenerative ataxia ( Ferro et al, 2017 ). Moreover, succinic acid derivatives, such as emoxipine, reamberin and mexidol, exert acute antidepressant effects by inhibiting monoamine oxidase activity ( Volchegorskii et al, 2019 ; Volchegorskii et al, 2020 ). For further process to identify the bioactive compound of succinum, we confirmed that EtOAc PSF was most similar to the PSE effect among the three fractions ( Supplementary Figures S2A,B ).…”

Section: Discussionmentioning

confidence: 99%

Succinum extracts inhibit microglial-derived neuroinflammation and depressive-like behaviors

Kang

Baek²,

Son³

et al. 2022

Front. Pharmacol.

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Microglia are emerging as important targets for the treatment of neuropsychiatric disorders. The phagocytic microglial phenotype and the resulting neuroinflammation lead to synaptic loss and neuronal cell death. To explore potential candidates that inhibit microglial hyperactivation, we first investigated ten candidate extracts of traditional Chinese medicine (TCM) using lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Among the candidates, Pinus spp. succinum extract (PSE) was superior; thus, we further investigated its pharmacological activity and underlying mechanisms both in vitro and in vivo. Pretreatment with PSE (10, 20, and 40 μg/ml) attenuated the increases in inflammatory factors (nitric oxide and tumor necrosis factor-α), translocation of nuclear factor-kappa B (NF-κB), and phenotypic transformations (phagocytic and migratory) in a dose-dependent manner. These inhibitory effects of PSE on microglia were supported by its regulatory effects on the CX3C chemokine receptor 1 (CX3CR1)/nuclear factor erythroid-2-related factor 2 (Nrf2) pathway. In particular, intragastric administration of PSE (100 mg/kg) considerably improved sickness, anxiety, and depressive-like behaviors in mice subjected to chronic restraint stress (CRS). Our results suggest that PSE has strong antineuroinflammatory and antidepressant properties, and the underlying mechanisms may involve not only the regulation of NF-κB translocation but also the normalization of the CX3CR1/Nrf2 pathway.

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Section: Discussionmentioning

confidence: 99%

Succinum extracts inhibit microglial-derived neuroinflammation and depressive-like behaviors

Kang

Baek²,

Son³

et al. 2022

Front. Pharmacol.

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“…3-Hydroxypyridine and its derivatives possess therapeutic properties (1-3) (Figure 1). The antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives was established (2). 2-Ethyl-6-methyl-3-hydroxypyridinium N-acetyl-Lglutamate has acute hypoxia and a neuroprotective effect on rats (3).…”

Section: Introductionmentioning

confidence: 99%

3-Hydroxypyridine and 3-(Hydroxymethyl)pyridine in the Synthesis of Salts of Aryldithiophosphonic Acids on the Basis of Monoterpenyl Alcohols

NİZAMOV,

YAKOVLEV,

NİZAMOV

et al. 2023

Journal of the Turkish Chemical Society Section A: Chemistry

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3-Hydroxypyridinium and 3-(hydroxymethyl)pyridinium O-terpenyl aryldithiophosphonates were obtained by the reactions of 3-hydroxypyridine and 3-(hydroxymethyl)pyridine with O-terpenyl aryldithiophosphonic acids on the basis of (1R,2S,5R)-(−)-menthol, (1S)-endo-(–)-borneol, racemic isoborneol, and carvacrol. The obtained salts possess high antimicrobial activity against Bacillus cereus and Candida albicans.

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Recent advances of small molecule fluorescent probes for distinguishing monoamine oxidase-A and monoamine oxidase-B in vitro and in vivo

Jian

Yan

Zhang

et al. 2021

Molecular and Cellular Probes

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The Effect of 3-Hydroxypyridine and Succinic Acid Derivatives on Hippocampal Monoamine Oxidase Activity in Rats with Alloxan-Induced Diabetes

Cited by 3 publications

References 14 publications

Succinum extracts inhibit microglial-derived neuroinflammation and depressive-like behaviors

Succinum extracts inhibit microglial-derived neuroinflammation and depressive-like behaviors

3-Hydroxypyridine and 3-(Hydroxymethyl)pyridine in the Synthesis of Salts of Aryldithiophosphonic Acids on the Basis of Monoterpenyl Alcohols

Recent advances of small molecule fluorescent probes for distinguishing monoamine oxidase-A and monoamine oxidase-B in vitro and in vivo

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