The effect of 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) on locomotor behaviour and muscle physiology of the sea cucumber Apostichopus japonicus

Zhuo, Pengji; Ding, Kang; Deng, Beini; Lai, Kaiqi; Zhang, Shuangli; Zhang, Libin; Yang, Hongsheng

doi:10.1016/j.marpolbul.2022.114198

Cited by 3 publications

(1 citation statement)

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“…The white powder of BDE-47 was first dissolved in dimethyl sulfoxide (DMSO), and then a specific amount was added to the seawater tanks to achieve the target concentrations. The working concentrations of BDE-47 were 0 µg/L in the control group, 0.1 µg/L in the low concentration group, 1.0 µg/L in the medium concentration group, and 10.0 µg/L in the high concentration group (Zhuo et al, 2022). The DMSO content was maintained at 0.001% in all groups (Jiang et al, 2017).…”

Section: Bde-47 Treatment and Sample Collectionmentioning

confidence: 97%

Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health

Ding,

Zhuo,

et al. 2023

Front. Mar. Sci.

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IntroductionSea cucumbers are cultivated mainly for their valuable body wall. Polybrominated diphenyl ethers are common persistent pollutants in sea waters with known impacts on aquatic animals nonetheless not yet studied for the body wall of sea cucumbers.MethodsUsing ltra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS), we investigated the metabolic impact of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the body wall of Apostichopus japonicus. etabolite changes and metabolic pathway alterations were assessed in response to three distinct concentrations of BDE-47: 0.1 µg/L, 1.0 µg/L, and 10.0 µg/L.REsultsExposure to BDE-47 led to notable alterations in the metabolic profiles of the body wall. A total of 95~102 metabolites in the 0.1 ~ 10.0 µg/L BDE-47 treated group were altered significantly, and various disrupted metabolic pathways were identified and characterized. These metabolites and metabolic pathways were mainly involved in lipid metabolism, energy metabolism, immunity, oxidative stress, inflammation, and neurotoxicity.DiscussionThe findings of our study shed light on the potential health risks that polybrominated diphenyl ethers present to sea cucumbers. This underscores the imperative for both researchers and policymakers to delve deeper into further investigations and studies. These results indicate the necessity for enhanced monitoring and management practices within the sea cucumber aquaculture industry to mitigate the impact of these persistent organic pollutants and protect the health and safety of this valuable resource.

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Section: Bde-47 Treatment and Sample Collectionmentioning

confidence: 97%