The effect of 17β-estradiol plus norethisterone acetate on blood pressure and inflammation markers: A meta-analysis of randomized controlled trials

Liu, Hong; Jin, Zuanming; He, Jing; Zhao, Lili; Yang, Jing Bo; Dai, Qiaomei; Zhang, Xianlin

doi:10.1016/j.ejogrb.2023.04.004

Cited by 2 publications

(2 citation statements)

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“…Another meta-analysis that assessed the specific effect of the combination of E2 and norethisterone acetate identified an increase in SBP, particularly in women aged 60 years or older, when used for more than 6 months. When the use was lower than 6 months, a decrease in DBP was observed 33 . The differences between this and the present meta-analysis may be related to the differences between the studied populations, with older women among the included studies, higher doses of E2, and differences in the progestogen used.…”

Section: Discussioncontrasting

confidence: 64%

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Effect of hormone therapy on blood pressure and hypertension in postmenopausal women: a systematic review and meta-analysis

Ferreira Campos,

de Andrade Costa,

Domingues Feitosa

et al. 2024

Menopause

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Importance Menopausal hormone therapy (HT) includes a wide variety of hormonal compounds, and its effect on blood pressure is still uncertain. Objective The aim of this study was to assess evidence regarding the effect of HT on blood pressure in postmenopausal women and its association with arterial hypertension. Evidence Review This systematic review and meta-analysis included randomized clinical trials and prospective observational studies. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and the incidence of hypertension were assessed. All stages were independently performed by two reviewers. For blood pressure outcome, standardized mean differences (SMD) and 95% confidence intervals (95% CI) were calculated as effect measures. Heterogeneity was assessed using the I 2 statistic. The results are presented based on the HT type. The incidence of hypertension was compared using descriptive analyses. Findings Eleven studies were included with 81,041 women evaluated, of which 29,812 used HT. The meta-analysis, conducted with 8 studies and 1,718 women, showed an increase in SBP with the use of oral conjugated equine estrogens plus progestogen (SMD = 0.60 mm Hg, 95% CI = 0.19 to 1.01). However, oral or transdermal use of estradiol plus progestogen (SMD = −2.00 mm Hg, 95% CI = −7.26 to 3.27), estradiol alone, and tibolone did not show any significant effect. No significant effect on DBP was observed for any formulation. Women who used oral estrogen plus progestogen had a higher risk of incident hypertension than those who never used it. Conclusions and Relevance The effect of HT on blood pressure is influenced by the formulation used, especially the type of estrogen. The combined formulations of conjugated equine estrogens plus progestogen increased SBP and the risk of hypertension, which was not observed among estradiol plus progestogen, estradiol alone, and tibolone users.

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Section: Discussioncontrasting

confidence: 64%

“…When the use was lower than 6 months, a decrease in DBP was observed. 33 The differences between this and the present meta-analysis may be related to the differences between the studied populations, with older women among the included studies, higher doses of E2, and differences in the progestogen used.…”

Section: Discussionmentioning

confidence: 64%

Effect of hormone therapy on blood pressure and hypertension in postmenopausal women: a systematic review and meta-analysis

Ferreira Campos,

de Andrade Costa,

Domingues Feitosa

et al. 2024

Menopause

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Investigating Interactions of Pathogenetic Factors in the Development of Arterial Hypertension and Obesity

Berzin,

Stelmakhivska,

Kondratiuk

2023

Act. Probl. of the Modern Med.

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This review is devoted to investigating the clinical, pathogenetic, and molecular mechanisms underlying the development of arterial hypertension and obesity, as well as their mutual impact on the progression of comorbidity. The literature review uncovers the mechanisms contributing to the emergence of various forms of cardioremodelling, taking into account the role of gender-specific factors. The article also presents current theoretical results and findings of clinical studies regarding how pathogenetic factors of arterial hypertension and obesity interact and influence on the progression of both diseases in case of their comorbidity. The influence of the gender, age, race, and seasonal variations in the course of arterial hypertension and obesity was highlighted as well. Special attention was paid to the issues considering the development of these diseases worldwide, age-related characteristics in the progression of this variant of comorbidity. When studying the problem of cardioremodeling in patients with arterial hypertension and in patients with comorbid arterial hypertension and obesity, two types of this pathological process (concentric and eccentric) were established. It has been shown that their development in men and women is significantly influenced by the type of obesity. This process is a gradually progressive disrupt of the structure and function of all parts of the heart, which lead to the development of structural and functional irreversible changes. This is especially clearly observed in patients with arterial hypertension and obesity, including those with type 2 diabetes.

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The effect of 17β-estradiol plus norethisterone acetate on blood pressure and inflammation markers: A meta-analysis of randomized controlled trials

Cited by 2 publications

References 81 publications

Effect of hormone therapy on blood pressure and hypertension in postmenopausal women: a systematic review and meta-analysis

Effect of hormone therapy on blood pressure and hypertension in postmenopausal women: a systematic review and meta-analysis

Investigating Interactions of Pathogenetic Factors in the Development of Arterial Hypertension and Obesity

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