The effect of 12-weeks concurent training on the serum levels NGF, BDNF, and VDBP in women with multiple sclerosis

Abstract

Recent studies suggest that patients with multiple sclerosis(MS) have low levels of neurotrophic factors such as nerve growth factor(NGF), brain-derived neurothrophic factor(BDNF) and the vitamin D-binding protein(VDBP), and exercise training may affects these factors in people with MS. The purpose of this study was to investigate the effect of a combined exercise training programon the serum levels of neurotrophic factos in women with MS. A randomized controlled clinical trial was conducted in 24 volunteer MS patients(Expanded Disability Status Scale range of 1–5). Resting serum levels of BDNF, NGF, VDBP, body composition variables, and disability scale values were determined before and after the intervention. The intervention consisted of three sessions of combined training a week for 12 weeks(two sessions of aerobic and one session of resistance training, progressively). Aerobic training consisted of interval training with 4-13 repetition of aerobic activity at 40-55% of heart rate reserve; and resistance training consisted of 8-12 repetitions with 60-80% of 1RM for eight movements. The results showed a significant decrease in body fat percentage (p=0.003) and disability scale value(p=0.007) in the experimental group. no other significant changes was observed for other variables or in the control group. This study indicates that although the combined aerobic and resistance training in three non-consecutive days per week for 12 weeks has no effect on NGF, BDNF, and VDBP; however with positive effects on the body fat percentage and disability scale value can be for women with MS.

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis—A Systematic Review and Meta-Analysis

“…Figure 1 presents a PRISMA flowchart of the study selection and screening process. Of the N = 337 studies identified from databases, N = 14 studies fulfilled the inclusion criteria [ 6 , 13 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. No additional studies were found through reference lists of the included studies.…”

Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

“…Results of BBB markers studies revealed a positive effect of exercise, particularly where s100 calcium‐binding protein B was investigated. Nine studies focused on neurotrophic factors (Table ) including brain‐derived neurotrophic factor (BDNF) , nerve growth factor , neurotrophin‐4 (one study), platelet‐derived growth factor and ciliary neurotrophic factor in pwMS. Among eight studies that investigated the effects of exercise training on BDNF, four studies reported a significant increase (see Appendix S1).…”

“…The sample size of some studies was very low (especially imaging markers) and four of six studies on magnetic resonance scan included only three to seven subjects per condition. Some studies of neurotrophic factors also had small sample sizes (<16 in each condition). These small samples increase the risk of a type II error.…”

The Compensatory Increased BDNF and NGF in Patients with Multiple Sclerosis Following Home-based Aerobic Training and Vitamin D Supplementation During COVID-19 Outbreak

“…Some of the bene cial effects of increased BDNF and NGF include direct stimulation, migration, and differentiation of oligodendrocytes (which are essential steps in myelinogenesis), upregulation of the activity and expression of cells necessary for myelin production (e.g., the main structural components of myelin, such as astrocytes and neurons), and regulatory proteins [46]. However, studies have reported that gene expression and secretion of neurodevelopmental factors, such as BDNF and NFG, function multiple molecular and non-molecular mechanisms [47,48]; Aerobic training might affect BDNF and NFG possibly through increased activity of some signaling pathways (PERK, pAkt, and CaMKII), increased expression of growth proteins such as 43-GAP, altered concentrations of hormones such as norepinephrine and serotonin, as well as the secretion of heat shock proteins, HSP27 and HSP70 [49,50]. In addition, vitamin D might affect the BDNF and NGF secretion and expression through nuclear signaling pathways secondary to the interaction of 1-25 (OH)…”