The Effect of 1-Hydroxy-1,1-Ethylidene Diphosphonic Acid on the Behavior of Male and Female Rats

Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid

“…That gives their derivatives a great potential to search for different types of biological activity in them. It has been shown that isolated single administration of HDA and BTP in the dose range from 5 to 200 mg/kg has analgesic activity, sedative and anxiogenic effects on the central nervous system and ability to change the indicators of the cardiorespiratory system [1][2][3][4]. In this regard, the screening of biological activity of HDA, BTP and HDA+BTP in the dose range from 5 to 200 mg / kg is appropriate and useful.…”