The effect of 0.25% and 0.5% pindolol on intraocular pressure in normal human volunteers

Tyas, Christine; Stewart-Jones, J. H.; Edgar, David F; Turner, Paul

doi:10.1185/03007998109112372

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Pindolol, a ßj-antagonist, lowered IOP when given topically to both normal (89)(90)(91)(92) and glaucomatous (93,94) human eyes. Studies have been done to determine the least dose of pindolol that is effective and that also minimizes side effects.…”

Section: Beta-adrenergic Drugsmentioning

confidence: 99%

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A Synopsis of Recent Developments in Antiglaucoma Drugs

McLaughlin¹,

Chiou²

1985

Journal of Ocular Pharmacology and Therapeutics

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Open-angle glaucoma is treated primarily with drugs, some of which have been used clinically for years. These drugs include: 1) cholinergic agonists that increase aqueous humor outflow, 2) adrenergic agonists and antagonist that affect both aqueous humor formation and outflow, and 3) carbonic anhydrase inhibitors that decrease aqueous humor formation.Several new classes of drugs are being tested for efficacy and mechanism of action. They include: 1) the D-isomer of timolol that reduces aqueous humor formation without producing adrenergic blockade, 2) dopaminergic agonists and antagonists, including bromocriptine and butyrophenones that reduce intraocular pressure, and 3) cannabinoids that reduce aqueous humor formation and increase outflow.In addition, several other types of drugs, such as prostaglandins, diuretics, Na+,K+-ATPase inhibitors, and adenyl cyclase stimulators are just now beginning to be studied.

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