The Effect and Safety of Short-Term Creatine Supplementation on Performance of Push-Ups

Armentano, Matthew J; Brenner, Alex K; Hedman, Travis L.; Solomon, Zack T; Chavez, Juliann; Kemper, George B; Salzberg, Daniel J.; Battafarano, Daniel F.; Christie, Douglas S.

doi:10.7205/milmed.172.3.312

Cited by 13 publications

(13 citation statements)

References 37 publications

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“…In the present study the researchers wanted to quantify increases in fluids caused by CrM supplementation and its affect on arterial pressure. Five existing studies were found in which arterial pressure was not affected following the loading phase of CrM supplementation [1,2,8,10,12] . However, none of these studies collected arterial pressure data daily as it was only recorded before and after the loading phase [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Five studies have found no significant change in arterial pressure before and after the loading phase of CrM supplementation [1,4,[12][13][14] . However, these studies did not measure the arterial pressure daily during the loading phase; hence any changes in arterial pressure may have gone undetected.…”

Section: Creatine Monohydrate: Daily Blood Pressure Monitoringmentioning

confidence: 99%

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Creatine Monohydrate: Daily Blood Pressure Monitoring During the Loading Phase of Supplementation

Kastello

2015

IJFNS

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Creatine monohydrate (CrM) is considered a safe nutritional supplement. The loading phase of CrM supplementation is associated with shifts in total body water and plasma volume that may affect blood pressure. However, few studies have measured blood pressure during the loading phase of CrM supplementation. Purpose: The aim of this study was to determine if CrM supplementation in normotensive college-aged males induces a daily blood pressure increase during the supplementation-loading phase. Methods: Participants' blood pressure, shoulder extension active range of motion (AROM), arm girth, arm volume, plasma volume, blood volume, hematocrit, and hemoglobin were measured daily for five days of supplementation (4x5gxd-1 x5d) of either CrM (n=12) or placebo (P; n=12). Results: The CrM group did not experience significant changes in systolic blood pressure (mmHg) (CrM 126.67±1.94 Day5 ; P 125.50±2.61 Day5) or diastolic blood pressure (mmHg) (CrM 83.83±2.19 Day5 ; P 82.33±2.07 Day5) compared to P. A significant T x Tx interaction (p=0.001) and Tx effect (p=0.03) support decreased AROM (cm) in the CrM group compared to P (CrM 38.3±2.19 Day 1 , CrM 34.0±2.01 Day5 ; P 41.02±2.49 Day 1 , P 43.2±2.47 Day5). An increase in arm volume (ml) in the CrM group (CrM 2443±99.44 Day 1 , CrM 2470±92.21 Day5) vs. the P group (P 2372±74.44 Day 1 , P 2374±74.61 Day5 ; p=0.026) was observed. An increase in plasma volume (%Δ from baseline) (p=0.014) (CrM 1.48±2.60 Day2 , CrM 6.03±4.03 Day5 ; P 3.25±2.74 Day2 , P 5.05±2.91 Day5) and a decrease in hematocrit (%) (p=0.026) (CrM 0.47±0.01 Day 1 , 0.45±0.01 Day5 ; P 0.46±0.01 Day 1 , 0.45±0.01 Day5) were observed. Conclusion: Findings suggest CrM supplementation in the loading phase does not affect blood pressure in normotensive college-aged males. CrM reduces shoulder extension AROM presumably due to increased tissue volume secondary to fluid shifts.

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Section: Discussionmentioning

confidence: 99%

Section: Creatine Monohydrate: Daily Blood Pressure Monitoringmentioning

confidence: 99%

Creatine Monohydrate: Daily Blood Pressure Monitoring During the Loading Phase of Supplementation

Kastello

2015

IJFNS

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“…Except for muscle cramps in two patients during the creatine period, there were no major side effects. Armentano et al studied the effects of creatine at a dose of 20 g/d for 7 days in healthy soldiers. From the point of view of safety and tolerability, there were no changes in the blood pressure, weight, body mass composition, and serum CK.…”

Section: Need For High‐dose Creatine Administration and Its Safetymentioning

confidence: 99%

Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain and muscle

Balestrino

Adriano

2019

Medicinal Research Reviews

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Creatine is pivotal in energy metabolism of muscle and brain cells, both in physiological and in pathological conditions. Additionally, creatine facilitates the differentiation of muscle and neuronal cells. Evidence of effectiveness of creatine supplementation in improving several clinical conditions is now substantial, and we review it in this paper. In hereditary diseases where its synthesis is impaired, creatine has a disease‐modifying capacity, especially when started soon after birth. Strong evidence, including a Cochrane meta‐analysis, shows that it improves muscular strength and general well‐being in muscular dystrophies. Significant evidence exists also of its effectiveness in secondary prevention of statin myopathy and of treatment‐resistant depression in women. Vegetarians and vegans do not consume any dietary creatine and must synthesize all they need, spending most of their methylation capacity. Nevertheless, they have a lower muscular concentration of creatine. Creatine supplementation has proved effective in increasing muscular and neuropsychological performance in vegetarians or vegans and should, therefore, be recommended especially in those of them who are athletes, heavy‐duty laborers or who undergo intense mental effort. Convincing evidence also exists of creatine effectiveness in muscular atrophy and sarcopenia in the elderly, and in brain energy shortage (mental fatigue, sleep deprivation, environmental hypoxia as in mountain climbing, and advanced age). Furthermore, we review more randomized, placebo‐controlled trials showing that creatine supplementation is safe up to 20 g/d, with a possible caveat only in people with kidney disease. We trust that the evidence we review will be translated into clinical practice and will spur more research on these subjects.

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“…A dose de suplementação habitualmente utilizada é de 2-6 g/dia por um período de 10 dias a 10 semanas 31 . Não há relatos de danos renais em indivíduos sadios que utilizam carnitina como suplemento dietético, mas há risco de agravamento da função renal em nefropatas 32 . No momento, não existem conclusões definitivas sobre o efeito benéfico da carnitina no metabolismo do exercício em atletas sem deficiência nutricional 3 .…”

Section: Carnitinaunclassified

Dietary supplement use by adolescents

Alves¹,

Lima²

2009

J Pediatr (Rio J)

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Objective: To review the use, benefits and adverse effects of the main dietary supplements consumed by adolescents. Sources:The literature review was performed using MEDLINE and LILACS databases (1997-2008). We analyzed 377 articles, and 52 of them were selected as references. Summary of the findings:Consumption of dietary supplements is widely spread among adolescents. This habit has often been detected in pediatric and adolescent medicine clinics. Most of the time, the use of supplements is motivated by the search of the "ideal body." Other reasons for this practice are: attempt to compensate for an inadequate diet, increase immunity, prevent diseases, improve athletic performance and overcome their own athletic limits. The dietary supplements most frequently used and for which there is little evidence of beneficial effects in healthy adolescents are: proteins, amino acids, beta-hydroxy-betamethylbutyrate, microelements, carnitine, creatine, vitamins, caffeine, and bicarbonate. This dietary supplementation may be beneficial for competitive athletes who do not have a balanced diet after a specific dietary deficiency has been detected. Conclusion:The unrestrained consumption of dietary supplements should be avoided, since, besides the lack of evidence that such practice will lead to improvement of performance, it exposes adolescents to several adverse effects. Balanced nutrition, with intake of essential energy and nutrients is usually enough to achieve good athletic performance. The use of dietary supplements must be allowed only for selected cases in which specific nutritional deficiencies are identified. J Pediatr (Rio J). 2009;85(4):287-294:Dietary supplements, exercise, sports, puberty. ResumoObjetivo: Revisar crititcamente o uso, benefícios e efeitos adversos dos principais suplementos alimentares utilizados por adolescentes. Fontes dos dados:A pesquisa bibliográfica, realizada nos últimos 10 anos, utilizou os bancos de dados MEDLINE e LILACS. Foram examinados 377 artigos, sendo selecionados 52. Síntese dos dados:O consumo de suplementos dietéticos é amplamente difundido entre adolescentes. Tal fato é constatado, com frequência, nos consultórios de pediatria e hebeatria. Na maioria das vezes ele ocorre sem uma necessidade específica, sendo motivado pela busca do corpo ideal. Outros motivos para essa suplementação são: compensar dieta inadequada, aumentar imunidade, prevenir doenças, melhorar o desempenho competitivo e superar os próprios limites. Os suplementos alimentares mais utilizados e discutidos nesse artigo e para os quais existem poucas evidências de um efeito benéfico de sua utilização por adolescentes saudáveis são: proteínas, aminoácidos, betahidroxibetametilbutirato, microelementos, carnitina, creatina, vitaminas, cafeína e bicarbonato.Conclusão: O uso irrestrito de suplementos dietéticos deve ser desaconselhado, uma vez que expõe o adolescente a vários efeitos adversos, além da falta de evidência de que tal prática levará a melhora no desempenho. Uma nutrição balanceada, com aquisição...

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The Effect and Safety of Short-Term Creatine Supplementation on Performance of Push-Ups

Cited by 13 publications

References 37 publications

Creatine Monohydrate: Daily Blood Pressure Monitoring During the Loading Phase of Supplementation

Creatine Monohydrate: Daily Blood Pressure Monitoring During the Loading Phase of Supplementation

Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain and muscle

Dietary supplement use by adolescents

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