“…However, long-term effects, which include instrument drift, temperature effects on the calibration blend, and barometric effects on sample size and detector sensitivity, all conspire to degrade the repeatability which can be obtained in practice. Osborne (6) has reported that records maintained over a period of several months show a long-term repeatability of ±8.2% relative at the 95% confidence level. Since the effect of these long-term variations can to a great extent be minimized through the use of on-line computer data acquisition and reduction, one can expect to see increasing use of on-line computers dedicated to process chromatographs.…”