The economics of diabetes care: a global perspective

Williams, Rhys

doi:10.1002/9781118387658.ch77

Cited by 8 publications

(2 citation statements)

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“…In 2013, diabetes caused 5.1 million deaths and cost USD 548 billion in healthcare spending – 30 percent of the total healthcare expenditure. 1 Type 2 diabetes mellitus (T2DM) accounts for 90% of all cases 2 with its incidence increasing and mirroring the worldwide increase in levels of obesity in adults and children. The causes of this epidemic are a complex interaction between genetic and epigenetic factors and societal influences that determine diet and levels of physical activity.…”

Section: Introductionmentioning

confidence: 99%

Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus

Chatterji

2018

Integrative Medicine Research

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BackgroundType 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by raised blood glucose levels and peripheral insulin resistance. It is an increasingly prevalent global healthcare concern. Conventional treatment options are limited and in this context, there is renewed interest in evaluating the clinical and biological effects of traditional therapies. We assess the effect of a new herbal composition SR2004 on the hemoglobin A1c (HbA1c), fasting blood glucose, and lipid profiles of patients with T2DM.MethodsThis is a single center, unblinded, prospective interventional study conducted in Israel. The composition SR2004 includes Morus alba, Artemisia dracunculus, Urtica dioica, Cinnamomum zeylanicum, and Taraxacum officinale. One hundred and nineteen patients with diagnosed T2DM were enrolled and received SR2004 in addition to their usual medications. HbA1c, fasting blood glucose, and lipid profiles at 12 weeks were compared with baseline. In addition, the tolerability and side effects of SR2004 were recorded.ResultsOne hundred and three patients completed 12 weeks of follow-up (87%) and were included in the results. At 12 weeks, HbA1c reduced from 9.0% to 7.1% (22%; p < 0.0001), mean blood glucose decreased from 211 mg/dL to 133 mg/dL (37% reduction; p < 0.0001), mean total cholesterol to 185 mg/dL (13% reduction; p < 0.01) and mean serum triglycerides to160 mg/dL (a reduction of 40% from baseline; p < 0.001). Twelve patients (12%) had no response with SR2004 supplementation. In addition, of thirteen patients who took insulin at baseline, five required only oral hypoglycemics and another five reduced their daily insulin requirements by 30% at 12 weeks. Clinical observations included improvements in vasculopathy, including reversal of established retinopathic changes in two patients.No major adverse effects were observed, with minor abdominal symptoms reported in sixteen patients (16%).ConclusionSR2004 supplementation significantly reduced HbA1c, blood glucose, and lipids with good tolerability and no observed adverse interactions with conventional medications. Some interesting findings relating to the reversal of microvascular phenomena warrant further research to elucidate the mechanisms of action of this novel composition.

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Section: Introductionmentioning

confidence: 99%

Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus

Chatterji

2018

Integrative Medicine Research

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“…Impaired or delayed wound healing is a major complication seen in various patients, especially in patients with diabetes. 1,2 There are several factors responsible for impaired wound healing, such as poor circulation, 3 diabetic neuropathy. 4,5 immune system deficiency, 6,7 infection, and stiffness of the arteries, 8 which lowers the supply of blood, nutrients, and oxygen to tissues and ultimately lowers the efficiency of white blood cells to fight against infection.…”

Section: Introductionmentioning

confidence: 99%

Bio fabrication of Copper Nanoparticles: A Next Generation Antibacterial Agent against Wound Associated Pathogens

Chauhan

Shrivastava

Tomar

2018

tjps

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Düzgün olmayan yara iyileşmesi önemli bir komplikasyondur. Kan glukoz düzeyi, zayıf dolaşım, bağışıklık sistemi eksikliği ve enfeksiyon gibi birkaç faktör düzgün seyretmeyen iyileşmenin temel nedenleridir. Bu çalışmanın amacı, yara ile ilişkili patojenlere karşı potansiyel antibakteriyel aktivitesi olan bakır nanopartiküllerin biyosentetik olarak üretilmesidir. Gereç ve Yöntemler: Bakır nanopartikülleri, Syzigium cumini yaprak ekstresinin metal tuzu çözeltisi ile karıştırılmasıyla sol-jel yöntemi kullanılarak üretildi. Parçacıklar daha sonra UV spektroskopisi, SEM, TEM, FTIR ve XRD kullanılarak karakterize edildi ve antibakteriyel aktiviteleri yara ile ilişkili olan dört patojene karşı MIC değerleri belirlenerek araştırıldı. Bulgular: TEM, SEM ve XRD karakterizasyonlarından elde edilen sonuçlar, parçacık boyutunun 100 nm'nin altında ve küresel şekilde olduğunu göstermiştir. FTIR analizi, bakır nanopartiküllerin kapatılmasında ve stabilize edilmesinde rol oynayan çeşitli biyomoleküllerin olasılığını göstermiştir. Sentezlenen parçacıklar, yara ile ilişkili dört patojene karşı (P. mirabilis, S. saprophyticus, S. pyogenes ve P. aeruginosa) antibakteriyel aktivite göstermiştir. Sonuç: Biyosentezlenmiş bakır nanopartiküller güçlü antimikrobiyal aktivite göstermiştir, bu nedenle sentezlenmiş bakır nanopartikülleri antibakteriyel aktiviteleri için çeşitli biyomedikal uygulamalarda kullanılabilir. Bununla birlikte, iyileşmeyen diyabetik yaralarda görülen enfeksiyonu tedavi etmek için daha iyi bir terapötik ajan olarak kullanılabilirler. Biyolojik yolla sentezlenen parçacıklar çevre dostu, daha az toksik, uygulanabilir ve uygun maliyetlidir. Anahtar kelimeler: Nanopartiküller, sol-jel süreci, biyosentez, karakterizasyon, yara ilişkili patojenler, biyomedikal uygulamalar Objectives: Impaired wound healing is a major complication. A few factors such as blood glucose level, poor circulation, immune system deficiency, and infection are the root causes of impaired wound healing. The aim of the present study was to bio-synthesize copper nanoparticles with potential antibacterial activity against wound-associated pathogens. Materials and Methods: Copper nanoparticles were fabricated using the sol-gel method with the mixing of Syzigium cumini leaf extract in metal salt solution. The particles were then later characterized using UV spectroscopy, SEM, TEM, FTIR, and XRD, and evaluated for their antibacterial activity and its MIC against four wound-associated pathogens. Results: The results obtained from TEM, SEM, and XRD characterization showed that the particle size was below 100 nm and of spherical shape. FTIR analysis showed the possibility of various biomolecules, which have a role in capping and stabilizing copper nanoparticles. The particles synthesized showed antibacterial activity against four wound-associated pathogens (P. mirabilis, S. saprophyticus, S. pyogenes, and P. aeruginosa). Conclusion: The biosynthesized copper nanoparticles showed potent antimicrobial activity, thus the antibacterial activity of the synthesized c...

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Type 2 Diabetes Mellitus (T2DM) in the Arab Society of Israel

Zalan¹,

Sharkia²

2021

Handbook of Healthcare in the Arab World

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The economics of diabetes care: a global perspective

Cited by 8 publications

References 46 publications

Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus

Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus

Bio fabrication of Copper Nanoparticles: A Next Generation Antibacterial Agent against Wound Associated Pathogens

Type 2 Diabetes Mellitus (T2DM) in the Arab Society of Israel

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