The economic potential of beach-cast seagrass – Cymodocea nodosa: a promising renewable source of chicoric acid

Abstract

Detrital and fresh specimens of the seagrass Cymodocea nodosa (Cymodoceaceae) from the Atlantic Ocean and Mediterranean Sea were screened for their phenolic content. For the first time, the major polyphenol was identified as chicoric acid (CA) by means of nuclear magnetic resonance, ultraviolet spectra, liquid chromatography/mass spectrometry, and comparison with standards. The CA content of the crude extracts was determined by quantitative high-performance liquid chromatography. The values found in the leaves ranged from 8.13 to 27.44 mg g -1 dw. The concentration was smaller in the rhizomes, with 0.31-3.70 mg g -1 dw. The phenolic profile was found to be similar whatever the geographical location in the Atlantic Ocean or the Mediterranean Sea. Considering the demonstrated therapeutic applications of CA, its high value on the nutraceutical market, and its rare occurrence in the plant kingdom, the high content found in C. nodosa detrital leaves makes this abundant biomass of interest for dietary and pharmaceutical applications.

Characterization and seasonal variation of individual flavonoids in Zostera marina and Zostera noltii from Norwegian coastal waters

“…63 The phenolic similarity between the studied Ruppia species and previously studied C. nodosa 69 could therefore be seen as additional verification of the close relationship between Ruppia species and other seagrass members of Cymodoceaceae. …”

“…Some of the most common flavonols, namely quercetin and isorhamnetin (Figure 2), have been identified in both Posidonia oceanica and Cymodocea nodosa. [68][69][70] In …”

High Value-Added Biomolecules from Beach Waste of Marine Origin-Screening for Potential Candidates among Seagrass of the Cymodoceaceae Family

“…Separation and quantification of phenolics in the crude extracts were performed as previously described [27] using the binary gradient 0.1% (v/v) TFA in water (A) and methanol (B). External standard calibration with chlorogenic acid dissolved in methanol/water (70:30) with the aid of sonication was established on six data points, covering the concentration range 0.0619-0.00619 mg.mL -1 .…”

“…We have recently reported the isolation of LCI and CA from the dead biomass of the tropical seagrass Syringodium filiforme [25,26], and CA from the temperate Cymodocea nodosa [27]. Considering the economic potential of these two substances within the pharmaceutical, cosmetic, and food industries, it appears of interest to evaluate the potential of other tropical members of Cymodoceaceae.…”

Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor

“…The activity of CA against the herpes simplex virus has been demonstrated [ 15 , 16 ]. The antioxidant activity of CA was found to be comparable with that of rosmarinic acid [ 17 , 18 ]. The anti-proliferative activity has been shown for CA [ 3 ], and anti-cancer, through inducing apoptosis of human colon cancer cells [ 19 ].…”